Exhaled air sampling device and sampling method for direct mass spectrometry detection

A sampling device and exhaled gas technology, which is applied in the field of direct mass spectrometry analysis of exhaled gas, can solve problems such as damage, affecting qualitative and quantitative analysis results, and reduce the detection sensitivity of ion mobility spectrometry, so as to achieve the effect of reducing sample loss and rapid dehumidification process

Inactive Publication Date: 2018-05-29
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, high content of water vapor affects important parts of analytical instruments, such as damaging the filament of the electron bombardment ionization source and the column of gas chromatography; on the other hand, high humidity of water vapor will make the analysis and detection process more complicated, such as reducing ion migration The detection sensitivity of the spectrum changes the form and ionization mechanism of the substance to be tested, which seriously affects the qualitative and quantitative analysis results

Method used

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  • Exhaled air sampling device and sampling method for direct mass spectrometry detection
  • Exhaled air sampling device and sampling method for direct mass spectrometry detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] If the refrigeration temperature controller is not set, the semiconductor refrigeration sheet and the air-cooled radiator will not work at this time. The tester exhales slowly facing the disposable sterile blowing nozzle. After the exhalation process is over, the sampling and analysis of the mass spectrometer starts immediately. A hygrometer is connected to the pipeline between the mass spectrometer inlet c and the mass spectrometer, and it can be read from the hygrometer. Under such conditions, the relative humidity of the sample in the buffer sample cell is 100% (37° C.). The spectrum collected by mass spectrometry was obtained without refrigeration and dehumidification, named "refrigeration not turned on - 100% RH" RH is the abbreviation of relative humidity.

Embodiment 2

[0026] Set the refrigeration temperature controller to 20 degrees, and at this time, the semiconductor refrigeration sheet and the air-cooled radiator work. The tester exhales slowly facing the disposable sterile blowing nozzle. After the exhalation process is over, the sampling and analysis of the mass spectrometer starts immediately. A hygrometer is connected to the pipeline between the mass spectrometer inlet c and the mass spectrometer, and it can be read from the hygrometer. Under this condition, the relative humidity of the sample in the buffer sample cell is 23% (26° C.). The spectrum collected by the mass spectrometer after being dehumidified by this refrigeration device is named "20°C-23%RH" and RH is an abbreviation for relative humidity.

Embodiment 3

[0028] Set the refrigeration temperature controller to 10 degrees, and at this time, the semiconductor refrigeration sheet and the air-cooled radiator work. The tester exhales slowly facing the disposable sterile blowing nozzle. After the exhalation process is over, the sampling and analysis of the mass spectrometer starts immediately. A hygrometer is connected to the pipeline between the mass spectrometer inlet c and the mass spectrometer, and it can be read from the hygrometer. Under such conditions, the relative humidity of the sample in the buffer sample cell is 11% (26° C.). The spectrum collected by mass spectrometry after dehumidification by this refrigeration device is named "10 degrees - 11% RH" RH is the abbreviation of relative humidity.

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Abstract

The invention discloses an exhaled air sampling device and sampling method for direct mass spectrometry detection. The method integrates a semiconductor cooling device and a mass spectrometer to achieve the direct mass spectrometry detection of components of exhaled end air and regulation of exhaled air humidity. The device includes a sealed buffer sample cell, two semiconductor cooling plates, two sets of air-cooled heat sinks, and a temperature controller. Four openings are arranged on the buffer sample cell, and the four openings are an exhaled air inlet, an exhaled air outlet, a mass spectrometer injection port, and a temperature measuring element inlet. When in sampling, the temperature controller is turned on, and cooling temperature is set. A tester breathes slowly and deeply through a sterile blowing mouth. After exhalation is completed, mass spectrometry instrument acquisition software is started to begin sampling. Through use of the exhaled air sampling device, the exhaled air humidity can be adjusted, the exhaled end air at different humidity can be obtained, and the exhaled air sampling device is favorable for researching the influence of the humidity on the analysis ofthe exhaled air.

Description

technical field [0001] The invention belongs to the field of direct mass spectrometry analysis of exhaled gas, and relates to a sampling device and a sampling method for direct mass spectrometry detection of exhaled gas. The device can quickly and effectively dehumidify the exhaled end gas, and the dehumidified samples are used for direct mass spectrometry analysis. Through the device, terminal exhaled air with different humidity can be obtained for studying the influence of humidity on exhaled air tested by direct mass spectrometry. Background technique [0002] Some products of human metabolism are carried by the blood to the lungs, where they appear in the exhaled air through gas exchange in the alveoli. Studies have reported that some substances are related to the metabolism and pathology of the body, and some substances may even become biomarkers of certain diseases, such as: formaldehyde is one of the markers of lung cancer; abnormal ammonia content reflects renal fai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N1/42G01N27/62
CPCG01N1/28G01N1/42G01N27/62
Inventor 李海洋王艳花磊王祯鑫渠团帅刘巍
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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