Water-soluble skin protection agent for protection against chemical toxicants, and preparation method and application thereof

Abstract

The invention discloses a water-soluble skin protection agent for protection against chemical toxicants, and a preparation method thereof, belonging to the field of dermatological protection against chemical toxicants. The water-soluble skin protection agent contains a butanone diacetyldioxime metal salt, an inorganic acid salt, a thickening agent and pharmaceutically acceptable adjuvants, whereinthe weight of the butanone diacetyldioxime metal salt accounts for 1-20% of the total weight of the protection agent, the weight of the inorganic acid salt accounts for 1 to 50% of the total weight of an ointment, and the weight of the thickening agent accounts for 0.1 to 50% of the total weight of agel, with the balance being the pharmaceutically acceptable adjuvants and water. The water-solubleskin protection agent can effectively prevent and delay permeation of all kinds of chemical toxicants (including neuro-toxicants, blister toxicants, irritant toxicants, industrial toxic corrosive chemicals and the like) into skin by forming a physical barrier film on a skin surface and stratum corneum, and can also degrade and destroy the toxicants before the toxicants entering blood circulation,thereby greatly reducing the harm of the toxicants to the skin and the body.

Description

technical field [0001] The invention belongs to the field of skin medicine protection against chemical poisons, and relates to a water-soluble skin protection agent formula containing butanone dioxime metal salt, inorganic acid salt, thickener and pharmaceutically acceptable auxiliary materials, as well as its preparation method and application. It is suitable for the protection of chemical agents such as erosive agents, nerve agents, and irritant agents before exposure to the skin. Background technique [0002] Chemical toxin skin protectant refers to the preventive preparation used before poisoning. By forming a physical barrier film on the skin surface, it can effectively prevent and delay the penetration of toxins into the skin, thus providing sufficient space for subsequent decontamination and treatment. time to significantly reduce combat attrition in chemical warfare conditions. [0003] Although the chemical poison skin protective agent (US military SERPACWA) curren...

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Problems solved by technology

[0003] Although the chemical poison skin protective agent (US military SERPACWA) currently equipped by foreign troops has the advantages of broad anti-virus spectrum, good anti-virus effect, and good film-forming performance, its protection mechanism is to form a very viscous hydrophobic film on the skin surface. Therefore, it has the disadvantages of being very viscous, not easy to apply on the skin surface, and difficult to remove, and the skin protectant is only a physical protection against the poison, it cannot decompose and destroy the poison, and it can still cause the possibility of poisoning and poisoning

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