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Chitosan slow-release microsphere-based liquid bandage

A technology of slow-release microspheres and chitosan, applied in the field of medical supplies, can solve the problems of small effective treatment area, repeated infection of wounds with pathogens, annoying wounds, etc., and achieve the effect of preventing pathogen infection and accelerating wound healing

Inactive Publication Date: 2018-06-08
YANTAI VOCATIONAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Ordinary Band-Aids have the following technical shortcomings: ①The air permeability of the adhesive tape is not good, and the air permeability of most ordinary Band-Aids is very poor, which means that the wound is always in a nearly anaerobic environment
This will bring two problems, one is that some anaerobic bacteria may have the opportunity to reproduce, such as our common tetanus bacilli; Make a series of reactions, such as surface cells will die and scab, and internal cells will proliferate to accelerate tissue healing)
Therefore, most people will remove the band-aid after the wound stops bleeding, but this may also lead to repeated infection of pathogens in the wound that has not healed, causing secondary inflammation
②The effective treatment area is too small, and the shape of many wounds is irregular, such as large area abrasions
In fact, most of the time this kind of wound is not deep, but due to the large area, the possibility of infection is quite high. This kind of wound is very annoying, not serious but easy to re-infect

Method used

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  • Chitosan slow-release microsphere-based liquid bandage
  • Chitosan slow-release microsphere-based liquid bandage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The liquid band-aid of the present embodiment consists of the following components: 10g of chitosan sustained-release microspheres, 18g of PVA, 30g of ethanol, 50g of purified water, 5g of ethyl acetate, 2g of vitamin E, 0.5g of citral, and 0.1g of ethylparaben , Glycerin 1.2g.

[0020] The preparation method of the liquid band-aid of the present embodiment is as follows: take the ethanol, ethyl acetate, purified water, citral, vitamin E of formula quantity and mix evenly, weigh the formula quantity of PVA and ethylparaben while stirring and add the mixed solution , airtight (to prevent volatilization) and stir until dissolved (generally, the time varies according to the total preparation quantity); add chitosan slow-release microspheres, and finally add glycerin and mix well.

Embodiment 2

[0022] The liquid band-aid of the present embodiment consists of the following components: 10g of chitosan sustained-release microspheres, 8g of PVA, 1g of PVP, 25g of ethanol, 50g of purified water, 5g of ethyl acetate, 0.5g of citral, 2g of vitamin E, ethylparaben 0.1g, glycerin 0.5g.

[0023] The preparation method of the liquid band-aid of the present embodiment is as follows: take the ethanol, ethyl acetate, purified water, citral, vitamin E of formula quantity and mix evenly, weigh the formula quantity of PVA and ethylparaben while stirring and add the mixed solution , airtight (to prevent volatilization) and stir until dissolved; add PVP to continue to dissolve completely, add chitosan slow-release microspheres, and finally add glycerin and mix well.

Embodiment 3

[0025] The liquid band-aid of the present embodiment is made up of following composition: chitosan sustained-release microsphere 10g, PVA10

[0026] g, ethanol 27.5g, purified water 50g, ethyl acetate 5g, vitamin E 2g, citral 0.5g, ethylparaben 0.1g, glycerin 1.2g, PVP 2g.

[0027] The preparation method of the liquid band-aid of the present embodiment is as follows: take the ethanol of formula quantity, ethyl acetate, purified water, citral, vitamin E and mix evenly, take the PVA formula quantity and add mixed solution while stirring, airtight (prevent volatilization) Stir until it dissolves (generally, the time varies according to the total preparation quantity); add PVP to continue to dissolve completely, finally add chitosan slow-release microspheres, and finally add glycerin and mix well.

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Abstract

The invention provides a chitosan slow-release microsphere-based liquid bandage, which is prepared from the following ingredients in parts by weight: 8 to 10 parts of chitosan slow-release microspheres, 8 to 18 parts of PVA, 25 to 30 parts of ethanol, 45 to 50 parts of pure water, 5 to 6 parts of ethyl acetate, 2 to 3 parts of vitamin E, 0.5 to 0.6 part of geranialdehyde, 0.1 to 0.12 part of ethylparaben and 0.5 to 1.2 parts of glycerol. The chitosan slow-release microsphere-based liquid bandage is prepared from a liquid film forming ingredient and medicine ingredients; a layer of covering film can be fast formed on the surface of the wound; the temporary skin effect is achieved; the ventilation (wound heeling acceleration), waterproof (pathogen infection prevention), hemostatic and anti-inflammatory effects are realized.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, in particular to a chitosan slow-release microsphere-based liquid band-aid. Background technique [0002] Ordinary Band-Aids have the following technical disadvantages: 1. The air permeability of the adhesive tape is not good. The air permeability of most ordinary Band-Aids is very poor, which means that the wound is always in an almost anaerobic environment. This will bring two problems, one is that some anaerobic bacteria may have the opportunity to reproduce, such as our common tetanus bacilli; Make a series of reactions, such as the surface cells will be necrotic and scab, and the internal cells will proliferate to accelerate the healing of the tissue). Therefore, most people will remove the Band-Aid after the wound stops bleeding, but this may also lead to repeated infection of pathogens in the unhealed wound, causing secondary inflammation. ②The effective treatment area is too sm...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0019A61L26/0023A61L26/0066A61L2300/236A61L2300/412A61L2300/622C08L39/06C08L5/08C08L29/04
Inventor 罗华丽马玉涛孙盟悦李伟炳刘鹏远
Owner YANTAI VOCATIONAL COLLEGE