Implants having a drug load of an oxysterol and methods of use

An oxidized sterol and implant technology, applied in the field of ductile implants and anti-compression implants, can solve problems such as bone defects that cannot match the shape

Active Publication Date: 2018-06-08
WARSAW ORTHOPEDIC INC
View PDF20 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This can be problematic in achieving effective bone growth in and through the desired implant volume due to scaffold particle migration or separation
Additionally, carrier scaffolds with a large amount of ceramic in them are rigid and often cannot fit irregularly shaped bone defects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Implants having a drug load of an oxysterol and methods of use
  • Implants having a drug load of an oxysterol and methods of use
  • Implants having a drug load of an oxysterol and methods of use

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0239] A first formulation of implants having the composition shown in Table 1 was prepared.

[0240] Table 1

[0241] CMC%

[0242] The values ​​listed in Table 2 refer to the composition of the dry powder components in the matrix before wetting with physiologically acceptable saline. Carboxymethylcellulose is added to impart adhesive properties to the implant. Carboxymethylcellulose has also been found to cause the implant to expand significantly after wetting. In some cases, carboxymethylcellulose allowed the implant to expand in some dimensions to twice the size of the dry compound. The collagen added to the composition is porcine type I fibrotic collagen. The ceramic contains beta tricalcium phosphate and hydroxyapatite in a ratio of 85:15. The ceramic particles have a particle size of about 125 μm to about 750 μm. Small particles are preferred to create a larger surface area to volume ratio to achieve faster absorption after implantation in a bone defect. ...

example 2

[0244] Formulations of moldable implants having the composition shown in Table 2 were prepared.

[0245] Table 2

[0246] Collagen%

[0247] The values ​​listed in Table 2 refer to the composition of the powder components of the matrix before wetting with physiologically acceptable saline. After wetting, the collagen was found to hold the implant together with little or no cross-linking. The collagen added to the composition is porcine type I fibrotic collagen. The ceramic contains beta tricalcium phosphate and hydroxyapatite in a ratio of 85:15. The ceramic particles have a particle size of about 125 μm to about 750 μm. Small particles are preferred to create a larger surface area to volume ratio to achieve faster absorption after implantation in a bone defect. A relatively high amount of ceramic is provided in the composition to impart compression resistance properties. Oxy133 was added to the composition at a level of about 400 mg / cc. Oxy133 was added in the...

example 3

[0249] Compositions were prepared according to the specifications of Example 1 or 2 above. Moisten the composition with sterile water.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
sizeaaaaaaaaaa
Login to view more

Abstract

Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.

Description

[0001] Cross References to Related Applications [0002] This application is in part an application filed on July 10, 2015 entitled "IMPLANTS HAVING A HIGH DRUG LOAD OF AN OXYSTEROL ANDMETHODS OF USE" Continuation of US Patent Application Serial No. 14 / 796,601. Background technique [0003] In medical applications, including fracture healing and surgical management of fractures in spinal conditions, biologics are often used to promote bone growth. Spinal fusion is often performed by orthopedic surgeons and similar neurosurgeons to address degenerative disc disease and arthritis affecting the lumbar and cervical spine, to correct deformation caused by scoliosis and to repair instability caused by spondylolisthesis sex. Alternatively, spinal fusion techniques can be applied to treat arm or leg pain caused by compressed nerves in the spine. Historically, autologous bone grafts, usually taken from the patient's iliac crest, have been used to enhance fusion between the vertebra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61K31/575
CPCA61L27/58A61L27/56A61L27/54A61L27/50A61L27/10A61L27/24A61L27/12A61L2430/02A61L2300/604A61L2300/414A61L2300/45A61L2300/412A61L2300/222A61L27/446A61L27/46A61F2210/0076A61F2230/0069A61K31/575A61K38/1709A61K38/1875A61L27/26A61L27/425
Inventor B·T·里夫斯D·S·谢尔R·E·哈林顿J·C·雅各布斯
Owner WARSAW ORTHOPEDIC INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap