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Preparation method for high-strength three-dimensional hollow hydrogel structural body

A structure and hydrogel technology, which is applied in the field of preparation of high-strength three-dimensional hollow hydrogel structures, can solve the problem of inability to prepare three-dimensional structural units of hydrogels, inability to use tissue and organ structure models, water Solve problems such as poor strength of the gel structure, achieve excellent mechanical properties, high strength, and good application prospects

Active Publication Date: 2018-06-15
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the strength of hydrogel structures prepared by 3D bioprinting technology is poor and cannot be directly used as tissue and organ structure models
In addition, the traditional 3D bioprinting technology cannot be used to prepare three-dimensional hydrogel structural units with a hollow structure.
Therefore, it is still a challenging work to develop a simple and feasible method for the formation and preparation of hydrogel structures.

Method used

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  • Preparation method for high-strength three-dimensional hollow hydrogel structural body
  • Preparation method for high-strength three-dimensional hollow hydrogel structural body
  • Preparation method for high-strength three-dimensional hollow hydrogel structural body

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Embodiment

[0029] Embodiment: the preparation of a kind of high-strength three-dimensional hydrogel structure comprises the following steps:

[0030] a. Preparation of iron-based polylactic acid (PLA@Fe) film material: Weigh 30 g of polylactic acid particles, add them to 200 mL of chloroform, stir rapidly until the particles are completely dissolved and the solution becomes transparent, then add 6 g of iron powder for After mixing and stirring for 30 min, the mixed solution was poured into a glass mold, and the PLA@Fe composite film material was formed after the solvent evaporated naturally.

[0031] b. Preparation of iron-based polylactic acid (PLA@Fe) wire: crush the PLA@Fe composite film material into granules, add it to the screw extruder, set the extrusion temperature rise program, the screw inlet temperature is 170 ℃, the cavity temperature The temperature was 175 °C, the outlet temperature was 180 °C, and a PLA@Fe wire with a diameter of 1.75 mm was obtained by simultaneous feedin...

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Abstract

The invention discloses a preparation method for a high-strength three-dimensional hollow hydrogel structural body. The method comprises the following steps: designing a corresponding solid element model according to the characteristic requirements of a hydrogel structural body; mixing a metal catalyst into a thermoplastic polymer or a light-curable resin material; printing a three-dimensional polymer structural body containing the metal catalyst through a 3D printer; soaking the polymer structural body into a hydrogel monomer solution, carrying out surface initiated polymerization, and allowing the surface of the polymer structural body to be able to grow a thickness-controllable hydrogel film in situ; soaking the polymer structural body with a gel layer into an ion solution, and carryingout network strength reinforcement; and removing the polymer structural body so as to be able to obtain a high-strength three-dimensional hollow hydrogel structural body similar to a design model. According to the invention, through modeling with computer software, and by relying on a high-precision 3D printing technical platform, a three-dimensional hollow hydrogel structural body material withan arbitrary shape and size can be prepared.

Description

technical field [0001] The invention belongs to the field of structured hydrogel preparation, and in particular relates to a preparation method of a high-strength three-dimensional hollow hydrogel structure. Background technique [0002] The preparation of bionic tissues and organs through new manufacturing technologies will bring fundamental changes to clinical medicine, which has important scientific and practical significance. How to precisely construct a system similar to organs and tissue structures has become one of the key challenges in the development of medical biomaterials in the 21st century. As a squishy and soft material, polymer hydrogel is similar to human organs and tissues in many aspects, and has shown good application prospects in the field of biomedicine. Therefore, it is of great significance to study the preparation of hydrogel structural units similar to human organs and tissues. However, so far, no breakthrough has been made in the preparation of hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08J3/24C08J7/12C08F220/56C08F220/06C08F222/14B29C64/124B29C64/20B33Y30/00
CPCB33Y30/00C08F220/56C08J3/24C08J7/12C08J7/16C08J2367/04C08J2433/26C08F220/06C08F222/102
Inventor 周峰麻拴红王晓龙
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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