Preparation method for high-strength three-dimensional hollow hydrogel structural body

Abstract

The invention discloses a preparation method for a high-strength three-dimensional hollow hydrogel structural body. The method comprises the following steps: designing a corresponding solid element model according to the characteristic requirements of a hydrogel structural body; mixing a metal catalyst into a thermoplastic polymer or a light-curable resin material; printing a three-dimensional polymer structural body containing the metal catalyst through a 3D printer; soaking the polymer structural body into a hydrogel monomer solution, carrying out surface initiated polymerization, and allowing the surface of the polymer structural body to be able to grow a thickness-controllable hydrogel film in situ; soaking the polymer structural body with a gel layer into an ion solution, and carryingout network strength reinforcement; and removing the polymer structural body so as to be able to obtain a high-strength three-dimensional hollow hydrogel structural body similar to a design model. According to the invention, through modeling with computer software, and by relying on a high-precision 3D printing technical platform, a three-dimensional hollow hydrogel structural body material withan arbitrary shape and size can be prepared.

Description

technical field [0001] The invention belongs to the field of structured hydrogel preparation, and in particular relates to a preparation method of a high-strength three-dimensional hollow hydrogel structure. Background technique [0002] The preparation of bionic tissues and organs through new manufacturing technologies will bring fundamental changes to clinical medicine, which has important scientific and practical significance. How to precisely construct a system similar to organs and tissue structures has become one of the key challenges in the development of medical biomaterials in the 21st century. As a squishy and soft material, polymer hydrogel is similar to human organs and tissues in many aspects, and has shown good application prospects in the field of biomedicine. Therefore, it is of great significance to study the preparation of hydrogel structural units similar to human organs and tissues. However, so far, no breakthrough has been made in the preparation of hy...

AI Technical Summary

Problems solved by technology

However, the strength of hydrogel structures prepared by 3D bioprinting technology is poor and cannot be directly used as tissue and organ structure models

In addition, the traditional 3D bioprinting technology cannot be used to prepare three-dimensional hydrogel structural units with a hollow structure.

Therefore, it is still a challenging work to develop a simple and feasible method for the formation and preparation of hydrogel structures.

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