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A technology of licorice extract and licorice, applied in separation methods, chemical instruments and methods, separation/purification of carbonyl compounds, etc., can solve the problems of single separated substance, single product, low recovery rate, etc., and achieve easy product collection and decolorization Clear and reproducible results
Active Publication Date: 2018-06-19
INFINITUS (CHINA) CO LTD
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Problems solved by technology
[0004] At present, there have been many inventions to extract licorice. However, the single extraction product is too single, and the licorice resources are not used up, which is a waste of resources. For example, in patent numbers 201610296645.3 and 201510102210.6, the two inventions all extract and purify glabridin. These inventions The extraction method mentioned in has many steps, repeated operations and long time, and there are too many types of organic solvents used, the final recovery rate is very low, and these methods can only extract a single glabridin, and cannot achieve multiple extracts. Extraction and decolorization of licorice extract, resulting in waste of other resources in licorice, unable to give full play to the overall efficacy of licorice
Patent No. 201410289036.6 uses reversed-phase C18 chromatography to separate glabridin in licorice, and the content of glabridin in the final isolate is >99%, but the cost of this method is high, and the separated product is single, and it is also unable to make full use of licorice other active ingredients in
Patent No. 201310178727.4 uses molecular imprinting technology to separate glabridin in licorice, but the disadvantage is that the separated substance is too single, except for glabridin, other components in licorice have not been fully recovered, and resources will be a bit wasteful
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Embodiment 1
[0051] (1) Preparation of molecularly imprinted polymer chromatography column: Add styrene to 2 mol / L sodium hydroxide solution and stir for 30 min to remove impurities therein. Take 30mL of the above-mentioned styrene, 400mL of water and 1g of licorice flavonoids (including 0.25g of liquiritigenin, 0.25g of liquiritin, 0.25g of isoliquiritigenin, 0.25g of isoliquiritin, the same below) and heat and stir at 75°C, then add 0.2 g of the crosslinking agent divinylbenzene, and finally 0.8 g of the initiator potassium persulfate were added thereto, and reacted for 13 hours under the protection of high-purity nitrogen to obtain a molecularly imprinted polymer containing glabridin. Then the polymer is pulverized and sieved, polymer particles of 40-100 meshes are taken, and the licorice flavonoid template in the molecular polymer is eluted with 50% acetic acid methanol solvent, finally obtaining the molecularly imprinted polymer without licorice flavonoid. Finally, the molecular polym...
Embodiment 2
[0056] (1) Preparation of decolorized molecularly imprinted polymer chromatography column: Add styrene to 2 mol / L sodium hydroxide solution and stir for 30 min to remove impurities therein. Take 30mL of the above-mentioned styrene, 400mL of water and 1g of licorice flavonoids (including 0.25g of liquiritigenin, 0.25g of liquiritin, 0.25g of isoliquiritigenin, 0.25g of isoliquiritin, the same below) and heat and stir at 75°C, then add 0.3g cross-linking agent (0.1g polyethylene glycol 400, 0.2g tetraethyl orthosilicate), finally 0.8g initiator potassium persulfate was added therein, and reacted for 13h under the protection of high-purity nitrogen to obtain glabridin-containing Molecularly imprinted polymers. Then the polymer is pulverized and sieved, polymer particles of 40-100 meshes are taken, and the licorice flavonoid template in the molecular polymer is eluted with 50% acetic acid methanol solvent, finally obtaining the molecularly imprinted polymer without licorice flavon...
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Abstract
The invention relates to the technical field of chemical extraction, particularly to a licorice root extract decolorizing method, which comprises: preparing a chromatography column filled with a molecularly imprinted polymer, wherein the molecularly imprinted polymer does not contain licorice root flavonoid; crushing licorice root, drying, and carrying out alcohol extraction to obtain a licorice root primary extract; loading the licorice root primary extract onto a decolorizing macroporous resin, collecting the filtrate, concentrating to prepare an extract, and dissolving the extract by usingan ethanol aqueous solution to obtain an initially decolorized licorice root extract; loading the initially decolorized licorice root extract onto the chromatography column filled with the molecularlyimprinted polymer, and collecting the filtrate; and concentrating the filtrate, carrying out centrifugation, collecting the filtrate, and carrying out vacuum drying to obtain the licorice root extract. According to the present invention, the colored licorice root flavonoid in the licorice root extract can specifically removed, and other colorless or light-colored functional ingredients can be retained; and the method can be used for the decolorizing treatment on skin coating products and other daily-use products, and has characteristics of strong specificity, high recovery rate of extract andsignificant decolorizing effect.
Description
technical field [0001] The invention relates to the technical field of chemical extraction, in particular to a decolorization method of licorice extract. Background technique [0002] Licorice (scientific name: Glycyrrhiza uralensis Fisch), aliases: Guolao, sweet grass, Ural licorice, sweet root. Perennial herbs, roots and rhizomes thick, 1-3 cm in diameter, brown outer skin, light yellow inner, sweet. Functions and indications: heat-clearing and toxic substances removing, eliminating phlegm and relieving cough, abdominal distension and so on. Licorice extract generally contains: glycyrrhizin, glycyrrhizic acid, glycyrrhizin, licorice flavonoids, pterostilbene, formononetin, quercetin, etc., and is yellow to brown yellow powder. It has the effects of invigorating the spleen and replenishing qi, clearing heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and relieving pain, and reconciling various medicines. [0003] The flavonoid component of...
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