Preparation method of extract capable of assisting lowering of blood glucose

An extract and hypoglycemic technology, which is applied in the field of biomedicine, can solve the problems of limited basic research on C.

Inactive Publication Date: 2018-06-22
JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the basic research on the costal flower is still very limited, which limits the subsequent promotion and application of this medicinal material.
[0009] At home and abroad, there are no relevant literature or patent reports on the preparation method of the auxiliary hypoglycemic extract from Licorice

Method used

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  • Preparation method of extract capable of assisting lowering of blood glucose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Preparation of auxiliary hypoglycemic extract

[0024] (1) Take stigmata, crush them, pass through a 20-mesh sieve, use petroleum ether as a solvent, extract 6 times at 40°C, and extract the dregs after petroleum ether extraction with a mixed solvent of ethyl formate-methanol with a volume ratio of 1:3.3. Extract 3 times at 45°C, each extraction time is 1.5 hours, and the amount of solvent used each time is 18 times the total weight of stigmata, filter, combine ethyl formate-methanol extract, recover solvent under reduced pressure, concentrate and dry to obtain crude extract Material B, the dregs after ethyl formate-methanol extraction are standby;

[0025] (2) Extract the dregs after ethyl formate-methanol extraction in step (1) with a water-ethanol mixed solvent with a volume ratio of 4:6, and extract 5 times at 50°C, each extraction time is 12 hours, each time the solvent The dosage is 9 times of the total weight of Stylophyllum, filter, combine the water...

Embodiment 2

[0033] Example 2: Preparation of auxiliary hypoglycemic extract

[0034] (1) Take stigmata, crush them, pass through a 20-mesh sieve, use petroleum ether as a solvent, extract 6 times at 40°C, and extract the dregs after petroleum ether extraction with a mixed solvent of ethyl formate-methanol with a volume ratio of 1:3.3. Extract 3 times at 45°C, each extraction time is 1.5 hours, and the amount of solvent used each time is 18 times the total weight of stigmata, filter, combine ethyl formate-methanol extract, recover solvent under reduced pressure, concentrate and dry to obtain crude extract Material B, the dregs after ethyl formate-methanol extraction are standby;

[0035] (2) Extract the dregs after ethyl formate-methanol extraction in step (1) with a water-ethanol mixed solvent with a volume ratio of 4:6, and extract 5 times at 50°C, each extraction time is 12 hours, each time the solvent The dosage is 9 times of the total weight of Stylophyllum, filter, combine the water...

Embodiment 3

[0043] Example 3: Preparation of auxiliary hypoglycemic extract

[0044] (1) Take stigmata, crush them, pass through a 20-mesh sieve, use petroleum ether as a solvent, extract 6 times at 40°C, and extract the dregs after petroleum ether extraction with a mixed solvent of ethyl formate-methanol with a volume ratio of 1:3.3. Extract 3 times at 45°C, each extraction time is 1.5 hours, and the amount of solvent used each time is 18 times the total weight of stigmata, filter, combine ethyl formate-methanol extract, recover solvent under reduced pressure, concentrate and dry to obtain crude extract Material B, the dregs after ethyl formate-methanol extraction are standby;

[0045] (2) Extract the dregs after ethyl formate-methanol extraction in step (1) with a water-ethanol mixed solvent with a volume ratio of 4:6, and extract 5 times at 50°C, each extraction time is 12 hours, each time the solvent The dosage is 9 times of the total weight of Stylophyllum, filter, combine the water...

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PUM

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Abstract

The technical scheme discloses a preparation method of extract capable of assisting lowering of blood glucose. The preparation method of the extract capable of assisting lowering of blood glucose comprises the following steps: by adopting herba lomatogonium rotatum as a raw material, carrying out extraction, carrying out separating, and carrying out purifying, thus obtaining the extract capable ofassisting lowering of blood glucose, which is composed of clauslactone V, repandusin and luteolin-7-glucoside.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a preparation method of an auxiliary blood-sugar-lowering extract, in particular to a preparation method of an auxiliary blood-sugar-lowering extract from styloid flower. Background technique [0002] Diabetes mellitus is a metabolic disease caused by insufficient insulin secretion or insensitivity of peripheral tissues to insulin. etc.) long-term impairment, insufficiency or failure. According to different pathogenesis, diabetes can be divided into type Ⅰ diabetes, type Ⅱ diabetes, gestational diabetes and other types of diabetes. [0003] According to statistics, in 2015, about 415 million people aged 20-79 in the world suffered from diabetes (8.8% prevalence rate), and another 318 million people had impaired glucose tolerance (pre-prevalence rate was 6.7%). China is the country with the largest number of diabetic patients in the world. In 2015, the number of patients was as high as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51C07D493/04C07H17/07C07H1/08A61K31/37A61K31/7048A61P3/10
CPCA61K31/37A61K31/7048A61K36/51A61K2236/333A61K2236/35A61K2236/39A61K2236/51A61K2236/55C07D493/04C07H1/08C07H17/07A61K2300/00
Inventor 不公告发明人
Owner JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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