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Reflective confocal microimaging system

A technology of confocal microscopy and imaging system, which is applied in medical science, diagnostics using tomography, sensors, etc. It can solve the problems of different imaging effects, insufficient imaging depth, and large volume of vivoscope, achieving light weight and freedom of use Large, high-resolution images

Pending Publication Date: 2018-06-29
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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Problems solved by technology

[0003] However, the confocal imaging method has some disadvantages: 1) The laser wavelengths used are relatively small. Due to the diversity of skin components, there are large differences in the absorption and reflection characteristics of various components for different wavelengths of light waves, which will lead to the use of different laser wavelengths. The imaging effect is different when the wavelength is small, and the best imaging effect cannot be achieved for specific skin components if the wavelength is small; 2) The imaging depth is insufficient
The vivoscope product of American LUCID company has a large volume, and the structure of the imaging head is relatively rigid, which cannot realize flexible switching of the imaging area.

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  • Reflective confocal microimaging system

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Embodiment Construction

[0021] Please refer to figure 1 A schematic structural view of a reflective confocal microscopy imaging system 100 provided for an embodiment of the present invention, including: a laser light source module 110, a polarizer module 120, a PBS beamsplitter prism 130, a galvanometer scanning module 140, a scanning lens 150, and an optical fiber hose 160 , fiber bundle module 170 , 1 / 4 wave plate 180 , objective lens 190 , pinhole lens 210 and detection module 220 . in:

[0022] The laser light source module 110 is used to provide a near-infrared polarized light source. It can be understood that the use of a near-infrared polarized light source has a certain advantage in imaging depth compared to a visible light source.

[0023] The polarizer module 120 includes a first polarizer 121 and a second polarizer 122 . The first polarizer 121 and the second polarizer 122 can adjust the light intensity of the laser light, and at the same time cooperate with the 1 / 4 wave plate 180 to ad...

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Abstract

The invention provides a reflective confocal microimaging system. An optical fiber bundle, a 1 / 4 wave plate and an objective lens are accommodated in an integrated optical fiber hose, and are combinedwith a confocal imaging technology, and thus it can be achieved that the reflective confocal microimaging system is small and portable. Besides, a doctor can flexibly detect the lesion area of a patient and is not limited by limiting disadvantages of universal arms anymore, and the reflective confocal microimaging system has low weight, a large using degree of freedom, and a high image resolutionrate.

Description

technical field [0001] The invention relates to the field of design and manufacture of a confocal microscopic imaging system, in particular to a reflective confocal microscopic imaging system. Background technique [0002] Skin computed tomography imaging, also known as skin confocal, skin CT is an important tool for skin disease detection. At present, the principle of confocal is mainly used, and the laser point light source is used to replace the wide-field light source to illuminate the sample. At the same time, a pinhole is used to form a point detection in front of the detector. The illumination point and the detection point are conjugate with respect to the focal plane of the objective lens. Points outside the focal plane are not imaged at the detection point, which effectively suppresses the effects of stray light. Through the scanning mechanism such as the galvanometer or the translation stage, the three-dimensional scanning imaging in space is formed, and the three...

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Application Information

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IPC IPC(8): A61B5/00
CPCA61B5/0068A61B5/0073
Inventor 缪新张运海薛晓君
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI