A human nk/t cell line

A cell line and deposit number technology, applied in the field of cell lines, can solve the problems of cancer patients without T-cell NK cells, the difficulty of purifying NK cells and T cells, the difficulty of mass expansion in vitro, and the time-consuming adoptive immunotherapy.
CN108220237BActive Publication Date: 2020-11-06INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
Publication Date
2020-11-06

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Abstract

The invention relates to a cell line, and specifically relates to a NK / T cell line of the human. The conservation number is CGMCC No. 14892. The NK / T cell line of the human provided by the invention can be passaged for a long time and greatly amplified, and has stronger anti-tumor activity, and provides a new experimental model for deeply development chronic activity EBV infectious disease mechanism research, screening chronic activity EBV infection, diagnosis molecular marker of EBV related lymphocytosis and the like, treating prognosis maker and treatment medicine, CD8+T cell, natural killercell anti-tumor action mechanism and clinic adoptive immunity treatment for a researcher.
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Description

technical field

[0001] The present invention relates to cell lines, in particular to a human NK / T cell line. Background technique

[0002] T cells can be divided into two subgroups according to whether they express CD4 or CD8 receptor molecules. CD8+ T cells are mainly responsible for the elimination of target cells through direct killing, such as cells infected by viruses and cells expressing tumor-specific antigens. Natural killer cells (NK cells) are important immune cells in the body, which have anti-tumor, anti-viral infection and immune regulation functions.

[0003] NK cells and T cells have long been considered excellent weapons for killing cancer cells and treating infections. Adoptive immunotherapy typically involves harvesting T cells from cancer patients, arming them with tumor-specific receptors in the laboratory, and reinfusing them back into the patient. However, adoptive immunotherapy is time-consuming, and cancer patients may not have enough T cells or NK...

Claims

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