Application of a water-soluble hypocrellin nanoassembly

Abstract

The invention discloses applications of a water-soluble hypocrellin nanometer assembly body as a light diagnosis and treatment integrated reagent for photoacoustic imaging and photothermal therapy oftumor tissues. According to the present invention, the water-soluble hypocrellin nanometer assembly body is prepared by using a hypocrellin drug and a natural or synthetic polymer as precursors through the self-assembly property between the hypocrellin drug and the natural or synthetic polymer, has the size of 20-200 nm and the maximum absorption wavelength range of 450-850 nm, can be simultaneously used for photoacoustic imaging and photothermal therapy of tumor tissues, can efficiently produce heat under laser irradiation so as to kill tumor cells, can be used for photoacoustic imaging of tumor tissues, can simultaneously diagnose and treat tumors, and further has advantages of light stability, strong anti-bleaching ability and good biocompatibility, wherein the photoacoustic imaging results display that the water-soluble hypocrellin nanometer assembly body can be efficiently enriched at tumor tissue after intravenous injection, photoacoustic imaging shows that it can be efficientlyenriched in tumor tissue; good light stability, strong anti-bleaching ability, and better biocompatibility.

Description

technical field [0001] The invention relates to the technical field of nanometer photodiagnosis and therapy drugs. More specifically, it relates to the application of a water-soluble hypocrellin nano-assembly. Background technique [0002] Photothermal Therapy (PTT) is a new technology for the treatment of tumor tissue that has developed rapidly in recent years. It has the advantages of high selectivity, high efficiency, non-invasiveness, and no damage to normal tissues. Another new technology of phototherapy besides Photodynamic Therapy (PDT). Specifically, photosensitizers will be enriched near the tumor, under laser irradiation (laser power 0.1-2W / cm 2 ), which can efficiently generate heat to rapidly increase the temperature of tumor tissue (generally greater than 50°C), and then kill tumor cells, thereby producing a therapeutic effect on tumor tissue (Nanoparticles for photothermal therapies, Nanoscale, 2014, 6, 9494). On the other hand, the thermal expansion generat...

AI Technical Summary

Problems solved by technology

No one pays attention to their photothermal effect. The reason is that hypocretin and its derivatives are mostly small organic molecules, which are easily inactivated under laser irradiation and do not have the effect of generating heat by light.

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