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Self-curing calcium phosphate bone repair material

A technology of calcium phosphate bone and repair material, applied in medical science, tissue regeneration, prosthesis, etc., can solve problems such as under-interpretation, and achieve the effect of strong practicability, simple preparation method and high repair efficiency

Active Publication Date: 2020-10-16
山东大学深圳研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, the research on TTCP mainly focused on improving the purity of the product, and seldom involved the material changes in the middle of its preparation reaction, and did not explain the key factors affecting product quality and the selection of calcination temperature.

Method used

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  • Self-curing calcium phosphate bone repair material
  • Self-curing calcium phosphate bone repair material
  • Self-curing calcium phosphate bone repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Experimental part

[0044] 1. Experimental plan

[0045] In this paper, the mixed powder of α-TCP (self-made) and DCPD (Chinese medicine) with a molar ratio of 2:1 was used as the raw material of CPC to contain 6wt.% citric acid and 0.5mol / L Na 2 HPO 4 The aqueous solution is the liquid phase, and its pH is 4.42, with HCTTCP (self-made, crystallinity eee>90%) and LCTTCP (self-made, crystallinity eee<40%) as additives respectively according to 2wt.%, 4wt.%, 5wt. %, 6wt.%, 8wt.%, and 10wt.% are evenly added to the CPC raw material, and the liquid-solid ratio is 0.4ml / g to quickly blend into a uniform paste, and the paste is quickly filled into a Φ6mm*12mm mold Molding, demoulding after a certain period of time, put the sample into an environment with a temperature of 37°C and a relative humidity of 100% for curing, and after it is completely cured, a CPC cured product is obtained, which is stored in bags.

[0046] The preparation method of α-TCP: first, DCPD (calcium ...

Embodiment 2

[0085] The preparation methods of α-TCP, HCTTCP and LCTTCP are the same as in Example 1. Adopt α-TCP and DCPD (national medicine) molar ratio as the mixed powder of 2:1 as CPC raw material, to contain 6wt.% citric acid and 0.5mol / LNa 2 HPO 4 The aqueous solution is liquid phase, its pH is 4.42, according to the ratio of 4.81wt.% HCTTCP (self-made, crystallinity eee>90%) and 0.19wt.% LCTTCP (self-made, crystallinity eee<40%) uniformly added to Among the CPC raw materials, a liquid-solid ratio of 0.4ml / g is used to quickly blend into a uniform paste, and the paste is quickly filled into a φ6mm*12mm mold for molding. After a certain period of time, the sample is demolded and the temperature is 37. °C, and the relative humidity is 100% for curing, and after the curing is complete, the CPC cured product is obtained, which is stored in bags. The compressive strength test results show that the compressive strength of TTCP / CPC cured product is 10.1MPa.

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Abstract

The invention provides a self-curing calcium phosphate bone repairing material. The self-curing calcium phosphate bone repairing material is prepared from the following raw materials: calcium phosphate powder and curing liquid, wherein TTCP is added in the calcium phosphate powder. The invention mainly aims to improve the mechanical property and the bioactivity of CPC by adding a certain amount ofhigh-crystallized tetracalcium phosphate (HCTTCP) and low-crystallized tetracalcium phosphate (LCTTCP) in the CPC without introducing other elements. The step is simple, the operation is convenient,and the practicability is high.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a self-solidifying calcium phosphate bone repair material. Background technique [0002] Self-curing calcium phosphate (CPC) is a non-ceramic hydroxyapatite (HAP) artificial bone material successfully developed in the United States several years ago. It overcomes the disadvantages of sintering and trimming of ceramic HAP, and has the advantages of easy preparation and convenient use. Since 1991, CPC has been used in clinical trials to repair skulls and achieved satisfactory results. [0003] At present, the self-curing calcium phosphate bone repair material (Calcium Phosphate Cement, CPC) has been extensively studied by scholars at home and abroad. High brittleness, poor bonding performance and insufficient mechanical properties. [0004] The paper "The Latest Research Progress of Self-curing Calcium Phosphate Artificial Bone" reported the latest research results of CPC, in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/50
CPCA61L27/12A61L27/50A61L2430/02
Inventor 王佃刚张维丽陈传忠
Owner 山东大学深圳研究院
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