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Drug Combination Formulation Containing Amlodipine, Losartan, and Chlorthalidone

A technology of amlodipine and losartan, which is applied in the field of drug compound preparations with solubility and stability, and can solve problems such as difficulties in the development of compound preparations, interactions that reduce dissolution rate and stability, and inability to be commercialized

Active Publication Date: 2021-04-09
HANMI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Although the compound preparations containing amlodipine, losartan and chlorthalidone with different pharmacological effects are increasingly needed in the field of clinical cardiovascular diseases as an effective treatment method, the drug interaction reduces the dissolution rate and stability, and the compound Formulation development is very difficult, so it cannot be commercialized

Method used

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  • Drug Combination Formulation Containing Amlodipine, Losartan, and Chlorthalidone
  • Drug Combination Formulation Containing Amlodipine, Losartan, and Chlorthalidone
  • Drug Combination Formulation Containing Amlodipine, Losartan, and Chlorthalidone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0054] Examples 1-3: Preparation of composite bilayer tablets by compression granulation

[0055] As shown in Table 1, amlodipine camphorsulfonate, chlorthalidone, lactose hydrate, microcrystalline cellulose, and crospovidone were mixed, and the mixture was passed through a 30-mesh sieve. The screened fraction was compacted into a pellet-like fraction using a roller press (roller wp200, Alexanderwerk) at a minimum pressure of 20 kN and a roller speed of 2-10 rpm. The above-mentioned particle part is subjected to shearing treatment with a grinder (Fitz grinder BAS 06, Fitzpatrick, USA), and after passing through a 20-mesh sieve, magnesium stearate is added to mix, and finally the mixture is mixed with a mixer to obtain amlodipine and chlorothiazide. Particulate fraction of ketones.

[0056] Combine losartan potassium, microcrystalline cellulose, and crospovidone, and sieve through a 30-mesh sieve. The screened fraction was compacted into a pellet-like fraction using a roller ...

Embodiment 4～6

[0083] Examples 4-6: Preparation of composite bilayer tablets containing different contents of active ingredients

[0084] As shown in Table 7, the usage-amount of the active ingredient of Examples 1-3 was changed, and the composite bilayer tablet was prepared.

[0085] Table 7

[0086]

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Abstract

The present invention relates to a drug compound preparation with improved solubility and stability, which comprises a first mixture containing amlodipine and chlorthalidone and a second mixture containing losartan. The compound preparation of the present invention can bring improved effects on the prevention or treatment of cardiovascular diseases by starting the different mechanisms of amlodipine, chlorthalidone and losartan, and it shows better results due to minimizing the interaction of drugs. High dissolution rate of losartan, amlodipine, chlorthalidone, and improved storage stability, so it is useful in the fields of medicine and medicine.

Description

technical field [0001] The present invention relates to a kind of medicine compound preparation containing amlodipine, losartan and chlorthalidone, more particularly, relate to a kind of medicine compound preparation with improved solubility and stability, it comprises a kind of medicine compound preparation containing amlodipine and chlorthalidone A first mixture of chlorthalidone and a second mixture containing losartan. Background technique [0002] About 90-95% of hypertensive patients suffer from primary (native) hypertension of no known cause. Although the underlying cause of essential hypertension is unknown, an increase in cardiac output (the volume of blood pumped by the heart each time the heart contracts) or an increase in peripheral vascular resistance can cause essential hypertension. Risk factors for hypertension include physical and environmental factors such as alcohol consumption, smoking, age factors, lack of exercise, obesity, dietary habits of eating sal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/24A61K9/20A61K31/4422A61K31/4178
CPCA61K31/4178A61K31/4422A61K9/209A61K31/4035A61P9/00A61P9/02A61P9/04A61P9/10A61P9/12A61K2300/00A61K9/2018A61K9/2054A61K9/2059A61K9/20A61K9/205A61K9/2086A61K9/2095
Inventor 金用镒林昊泽卢利东尹英洙朴宰贤禹钟守
Owner HANMI PHARMA