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Plant empty capsule for inhaling medicament and capsule agent thereof

A plant hollow capsule and capsule wall technology, applied in the directions of capsule delivery, drug combination, drug delivery, etc., can solve the problems of affecting drug inhalation and treatment effect, poor oxygen barrier effect, and not easy to break, so as to improve drug efficacy and preservation. time, the effect of improving oxygen barrier properties and improving toughness

Inactive Publication Date: 2018-07-20
上海祺宇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the hydroxypropyl methylcellulose capsules prepared now are easy to absorb dry powder active ingredients, which affects the inhalation and therapeutic effect of the drug; in addition, compared with gelatin capsules and pullulan capsules, the oxygen transmission rate of hydroxypropyl methylcellulose capsules Higher, the oxygen barrier effect is not good, and the drugs in it are easily oxidized and invalidated; finally, although compared with gelatin capsules, hypromellose capsules are less likely to break when used (referring to piercing) (better toughness) , but there are still cases where the capsule fragments are broken, so it is necessary to further improve the toughness of the cellulose capsule

Method used

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  • Plant empty capsule for inhaling medicament and capsule agent thereof
  • Plant empty capsule for inhaling medicament and capsule agent thereof
  • Plant empty capsule for inhaling medicament and capsule agent thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～15

[0043] According to the raw material formula shown in Table 1 and Table 2, the 3# vegetable hollow capsule of the present invention is prepared with reference to the following method.

[0044] 1. Dissolving hydroxypropyl methylcellulose in water at a temperature of T1 makes a mass fraction of an aqueous cellulose solution of X, and immersing the 3# capsule mold described in Table 1 and Table 2 in the cellulose solution at a temperature of T2, Take out and dry at T3 temperature, form a layer of cellulose film on the surface of the capsule mold and cool to room temperature. Wherein, the surface roughness of the stainless steel mold is 10nm, the surface roughness of the fluoroplastic is 8nm, and no release agent is applied on the surface of the mold.

[0045] 2. Dissolve / disperse the coating material in ethanol at room temperature to make a solution or emulsion.

[0046] 3. Immerse the mold containing the cellulose film on the surface into the coating ethanol mixture, take it ou...

Embodiment 16～19

[0054] Refer to the raw materials and preparation methods of Examples 12-15, without the plasma treatment described in step 4, and the others are the same, to prepare the 3# plant hollow capsule of the embodiment of the present invention.

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Abstract

The invention discloses a plant empty capsule, which contains one or various kinds of cellulose. The roughness of the inner surface of the capsule wall is smaller than 20nm.The smoothness of the innersurface of the plant empty capsule is high; a mold release agent is not used; the problem that medicine in a dry powder inhalation preparation is easily stuck on the capsule wall is solved. Further,through a coating at the outer surface of the empty capsule, the oxygen barrier property is improved; the oxidation effect of oxygen gas on capsule contents is retarded; the medicine effect and the storage time of medicine are improved; the toughness is also improved through the coating; fragments cannot be easily generated when the capsule is pierced; the condition that the capsule fragments areinhaled into the human body along with the medicine is avoided.

Description

technical field [0001] The invention relates to the field of capsules, in particular to a plant hollow capsule used for inhaling medicaments and a capsule thereof. Background technique [0002] The treatment of many lung diseases and disorders currently adopts the method of inhalation drug delivery, and the medicinal active ingredients are directly applied to the lungs through inhalation, so that patients can get better therapeutic effects. The administration methods of inhalation preparations are mainly divided into three types: nebulizers, metered-dose aerosol inhalation preparations and dry powder inhalation preparations. Among them, dry powder inhalation preparations are more popular for patients who can adjust the dosage according to their individual breathing patterns, and dry powder inhalation preparations are easy to produce and cheap, and capsules can be used as drug-carrying containers for dry powder inhalation preparations. [0003] At present, capsules are mainl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/72A61K47/38A61K47/34A61K47/10A61K47/14A61K47/44A61K47/06A61P11/00
CPCA61K9/4891A61K9/007A61K9/4816A61K47/06A61K47/10A61K47/14A61K47/34A61K47/38A61K47/44
Inventor 马雪华张宇
Owner 上海祺宇生物科技有限公司