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Application of carbamazepine to preparation of medicines for treating flavivirus infection

A virus infection, flavivirus technology, applied in the field of medicine, to achieve the effect of reducing mortality and good safety

Active Publication Date: 2018-07-24
武汉百药联科科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no precedent for the use of carbamazepine in the treatment of flavivirus infections

Method used

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  • Application of carbamazepine to preparation of medicines for treating flavivirus infection
  • Application of carbamazepine to preparation of medicines for treating flavivirus infection
  • Application of carbamazepine to preparation of medicines for treating flavivirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Application of embodiment 1 carbamazepine in the treatment of mice infected with Japanese encephalitis virus

[0030] 1. Construction of a mouse model infected with Japanese encephalitis virus

[0031] 1. Experimental materials

[0032] (1) Experimental animals: four-week-old Balb / c female mice.

[0033] (2) Virus strain: JEV P3 strain

[0034] (3) Other reagents:

[0035] 1) 0.01M PBS buffer: weigh NaH 2 PO 4 0.593g, Na 2 HPO 4 5.802g, NaCl 17.0g, deionized water (ddH 2 O) Dilute to 2L, store at room temperature for later use.

[0036] 2) DMEM basal medium: a bottle of DMEM powder, weighed NaHCO 3 3.7g, HEPES5.95g, add 800mLddH 2 O, stir well to dissolve, dilute to 1000mL, sterilize with a 0.22μm filter, and store at 4°C for later use.

[0037] 2. Experimental steps

[0038] Mice were injected intraperitoneally with 10 6 PFU Japanese encephalitis virus, the mice in the control group were intraperitoneally injected with the same dose of DMEM medium. In ...

Embodiment 2

[0056] Example 2 Drug efficacy prediction experiment based on flavivirus infection personalized drug method

[0057] (1) Obtain the gene expression data of Japanese encephalitis virus-infected patients, West Nile virus-infected patients and healthy people.

[0058] The chip data (series: GSE57647, GSE43190) of Japanese encephalitis virus patients, West Nile virus infected patients and control group were downloaded from NCBI GEO Dataset, and a total of 6 Japanese encephalitis virus infected patients and 18 infected patients were obtained. Gene expression data from West Nile virus patients.

[0059] (2) Calculating the key gene list of patients with flavivirus infection

[0060] Based on the gene names in the 24 chip data downloaded in (1) and the gene interaction information downloaded from the STRING database, construct a gene interaction matrix, and calculate the multiple difference value of each gene in each patient as the initial importance input into the GeneRank algorith...

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Abstract

The invention discloses application of carbamazepine to preparation of medicines for treating flavivirus infection, particularly application of the carbamazepine to preparation of a medicine for treating Japanese b encephalitis virus infection, a medicine for treating Zika virus infection, a medicine for treating West Nile virus infection, a medicine for treating yellow fever virus infection and amedicine for treating 1-4 type dengue virus infection. The carbamazepine can effectively reduce the death rate of mice infected with Japanese b encephalitis virus; in addition, the carbamazepine hasbeen applied clinically for a long time and has high safety. Therefore, the carbamazepine can be further developed to serve as a medicine for treating flavivirus infection and provide new choice for clinical medication.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of carbamazepine in the preparation of medicines for treating flavivirus infection. Background technique [0002] The Flavivirus family (Flaviviridae) is an enveloped single-stranded positive-sense RNA virus, which is transmitted by blood-sucking arthropods (mosquitoes, ticks, sandflies, etc.) to cause infection. The flavivirus genus includes about 70 viruses, most of which are pathogens of zoonotic infectious diseases, such as Japanese encephalitis virus (Japanese encephalitis virus, JEV), West Nile virus (WNV), yellow fever Virus (Yellowfevervirus, YFV), Dengue virus (DENV) type 1-4, Zika virus (Zika virus, ZIKV), etc. [0003] The gene of the flavivirus genus is a single-stranded positive-strand RNA, about 11kb in length, with a non-coding region (UTR) at the 5' end and a 3' end, a methylated cap structure at the 5' end, and a methylated cap structure at the ...

Claims

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Application Information

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IPC IPC(8): A61K31/55A61P31/14
CPCA61K31/55Y02A50/30
Inventor 张红雨吕博敏全源张青叶黄清
Owner 武汉百药联科科技有限公司
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