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A composition having the effect of preventing and treating diabetes, its preparation method and application

A composition and technology of diabetes, which are applied in the field of composition and its preparation with the effect of preventing and treating diabetes, can solve the problems of inconsistent treatment, lack of clinical drug efficacy research, and treating the symptoms but not the root cause.

Active Publication Date: 2020-12-29
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many drugs for the treatment of diabetes and its complications. Although the western medicines used clinically have certain curative effects, most of them have relatively large adverse reactions, such as rebound after drug withdrawal, liver and kidney damage, rhabdomyolysis and other side effects. , cure the symptoms but not the root cause, and traditional Chinese medicine has its unique advantages in the treatment of diabetes, which has the advantages of long-lasting curative effect and no obvious side effects. , and the prescriptions of traditional Chinese medicine are based on different principles, and the treatment principles are not uniform.

Method used

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  • A composition having the effect of preventing and treating diabetes, its preparation method and application
  • A composition having the effect of preventing and treating diabetes, its preparation method and application
  • A composition having the effect of preventing and treating diabetes, its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] 1. Optimization test of mulberry leaves ethanol reflux extraction process

[0100] factor level design

[0101] Use L 9 (3 4 ) orthogonal design table, taking the contents of rutin and total flavonoids in mulberry leaves as indicators, and investigating the effects of alcohol concentration, solid-liquid ratio, and extraction times on the extraction of index components.

[0102] Table 1 Orthogonal test factor level table

[0103] factor Alcohol concentration (%) B Ratio of material to liquid C extraction times D blank 1 60 1:8 1 1 2 70 1:10 2 2 3 80 1:12 3 3

[0104] 2. Result analysis

[0105] Follow L 9 (3 4 ) orthogonal table for orthogonal test, weigh 10g of mulberry leaf medicinal material, add ethanol to reflux, filter, and combine the medicinal liquid. Each group of experiments was performed 3 times in parallel.

[0106] Table 2 Orthogonal test results

[0107]

[0108]

[0109] Table 3 Rutin analysis of ...

Embodiment 2

[0137] The composition with anti-diabetes effect is made of the following raw materials in parts by weight:

[0138] 125g of mulberry leaf extract, 125g of tartary buckwheat extract, 250g of Dendrobium candidum, 125g of Ganoderma lucidum spore powder.

[0139] The mulberry leaf extract is prepared by the following method: take mulberry leaves, add 10 times the volume concentration of 80% ethanol to reflux and extract twice, each time for 1.5 hours, and filter to obtain an ethanol extract; Extract twice the amount of water once, 1.5 hours each time, filter to obtain the water extract, combine the ethanol extract and water extract, concentrate under reduced pressure to a relative density of 1.20 at 60°C, and set aside; take the concentrated solution, reduce pressure or spray Dried, pulverized, and sieved to obtain the mulberry leaf extract;

[0140] The tartary buckwheat extract is prepared by the following method: take tartary buckwheat, add 10 times the volume concentration o...

Embodiment 3

[0144] The quality identification method of the composition with anti-diabetes effect described in embodiment 2: comprise the following steps:

[0145] (1) Qualitative research

[0146] (1.1) Microscopic identification of Ganoderma lucidum broken spore powder

[0147] Microscopic identification: Ganoderma lucidum broken spore powder is a brown powder, extremely delicate in appearance, without agglomeration, lightly touched with the thumb and index finger, it has a smooth and delicate feeling, no adhesion, no foreign matter such as sand and gravel ;Under the magnification of 1500 times, the unbroken spores are complete, plump, with clear double-walled structure, colorless outer wall, and small spines on the inner wall, light brown; the individual shape is consistent and oval; the top is truncated, and the size is about 8.5 ~11×5.2~6.9μm; and broken spores have several forms, which can be divided into mild broken wall according to different breaking procedures---spores with com...

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Abstract

The invention discloses a composition having the functions of preventing and treating diabetes and a preparation method and application thereof. The composition is prepared from mulberry leaves, tartary buckwheat, fendrobium candidum and ganoderma lucidum spore powder. According to the theory of traditional Chinese medicine, the results of a large number of experiments for screening raw materialsand selecting a weight ratio show that the composition has the best composition of mulberry leaf extract, tartary buckwheat extract, fendrobium candidum and ganoderma lucidum spore powder. The preparation method can improve content of active ingredients such as active polysaccharide, rutin, quercetin and naringenin. The composition has functions of reducing blood sugar and blood fat, is environmentally friendly and safe, and has no toxic or side effect after long-term use. The preparation method has a reasonable design and realizes industrial production.

Description

technical field [0001] The invention relates to a composition, in particular to a composition with the effect of preventing and treating diabetes and its preparation method and application. Background technique [0002] Diabetes is a common and frequently-occurring disease worldwide, and has become the third largest disease after tumors and cardiovascular diseases. Diabetes combined with stasis and heat is the main complication of diabetes. Diabetic heart disease is common clinically. Diabetic heart disease includes diabetes-specific cardiomyopathy, diabetes-related cardiac microvascular disease, macrovascular disease, cardiac autonomic neuropathy, etc. , and often accompanied by non-specific coronary atherosclerotic heart disease and (or) hypertensive heart disease, on the basis of diabetes, can be collectively referred to as diabetic heart disease. Compared with coronary atherosclerotic heart disease and cardiomyopathy in non-diabetic patients, diabetic heart disease has ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61P3/10A61P3/06G01N30/02A23L33/00
CPCA23V2002/00A61K36/074A61K36/605A61K36/70A61K36/8984A61K2236/331A61K2236/333A61K2236/39A61K2236/51A23L33/00G01N30/02A61K2300/00A23V2200/328
Inventor 王旭狄留庆许惠琴吴滨
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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