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Steady persistence nano material activated by low-dosage X rays and application thereof

A nanomaterial, long afterglow technology, applied in the field of medicine, can solve problems such as the limitation of photodynamic therapy, and achieve the effect of reducing the dosage, reducing side effects, and improving the therapeutic effect

Inactive Publication Date: 2018-07-24
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the tissue penetration depth of near-infrared light is only about 1 cm, and the photodynamic therapy of deeper tissues is still limited.

Method used

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  • Steady persistence nano material activated by low-dosage X rays and application thereof
  • Steady persistence nano material activated by low-dosage X rays and application thereof
  • Steady persistence nano material activated by low-dosage X rays and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Synthesis of Tungsten, Chromium Double Doped Long Persistence Nanoparticles

[0026] Weigh 0.2668 g Zn(NO 3 ) 2 •6H 2 O, 0.4565 g Ga(NO 3 ) 3 • xH 2 O, 0.0015 g Na 2 WO 4 • 2H 2 O and 0.0018 g Cr(NO 3 ) 3 •9H 2 O, mix and place in a 50 mL beaker, add 16 mL of ultrapure water, ultrasonically dissolve, stir rapidly at room temperature, then adjust the pH to 6.5 with ammonia water (28 wt%), a white precipitate is formed during the process, and continue stirring for 30 min , then transfer the mixture to a 25 mL autoclave, react at 180 °C for 12 h, then wash three times with 9000 rpm centrifugal water, dry in an oven at 60 °C, grind the obtained sample into powder, and calcinate in a muffle furnace at 950 °C 4h. Synthetic ZnGa 1.99 o 4 :0.005Cr, 0.005W (ZGO:Cr / W) long afterglow nanoparticles.

[0027] figure 1 The TEM image (a) and high-resolution TEM image (b) of the prepared ZGO:Cr / W long-lasting nanoparticles. Such as figure 1 As shown, it can ...

Embodiment 2

[0029] Example 2 Surface Amination of ZGO:Cr / W Long Persistence Nanoparticles

[0030] A small amount of ethanol was added to the ZGO:Cr / W long-lasting nanoparticle powder prepared in Example 1, wet ground for 30 min, and then the sample was ultrasonically dispersed in 10 mL of 5 mM NaOH solution for 3 h, and then stirred rapidly for 12 h. After the reaction, the dispersion was first centrifuged at 1000 rpm for 5 min to remove large particles, and then centrifuged at 8000 rpm to collect the precipitate, which was then centrifuged and washed once with water and once with DMF. The obtained precipitate was redispersed in 10 mL of DMF, and then 80 μL of aminopropyltriethoxysilane (APTES) was added, and the reaction was stirred rapidly in an oil bath at 85 °C for 12 h, and the aminated long-lasting particles (ZGO:Cr / W-NH 2 PLNPs), washed several times with DMF and water respectively to remove unreacted APTES, and finally dispersed in 5 mL water to make a concentration of 2.5 mg·m...

Embodiment 3

[0031] Example 3 Construction of Long Persistence Nanomaterials (ZGO:Cr / W-ZnPcS4)

[0032] Take 6 mL of 200 μg mL -1 The concentration of the photosensitizer ZnPcS4 prepared in Example 2 with 4 mL is 2.5 mg·mL -1 ZGO:Cr / W-NH 2 solution, mixed with ultrasound for 30min, and then reacted with rapid stirring at room temperature for 24h, and the obtained ZGO:Cr / W-ZnPcS4 nanoparticles were centrifuged and washed three times at 8500 rpm to remove excess ZnPcS4, and then redispersed in 5 mL of ultrapure water. into a concentration of 2 mg·mL -1 ZGO:Cr / W-ZnPcS4 solution.

[0033] image 3 Infrared spectrum (a) and zeta potential (b) of the ZGO:Cr / W-ZnPcS4 nanoparticles prepared in Example 3. Such as image 3 As shown, ZGO:Cr / W-ZnPcS4 has been successfully constructed.

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Abstract

The invention discloses a steady persistence nano material activated by low-dosage X rays and application thereof. The steady persistence nano material is prepared by adopting the steps that firstly,new tungsten and chromium doped steady persistence nano particles ZnGa2O4: W, Cr are synthesized, amination treatment is conducted on the surfaces of the steady persistence nano particles, the surfaces of the steady persistence nano particles are modified with a photosensitizer, and the steady persistence nano material is prepared. The steady persistence nano material has a steady persistence luminescence characteristic and the high luminescent intensity, and can be activated by the low-dosage X rays, the steady persistence nano material can solve the problem that a traditional photosensitizercannot conduct deep tissue photodynamics therapy due to the penetrating power is not strong enough, photodynamics therapy to the deep tissues is achieved, and meanwhile, the photodynamics therapy effect can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a low-dose X-ray-activated long-lasting nanometer material and its application. Background technique [0002] In the field of cancer diagnosis and therapy, light-guided diagnostic imaging and therapy have seen rapid development. However, although many research achievements have been made in the field of light-guided diagnosis and treatment, the further development is still limited due to the insufficient tissue penetration ability of the light source in the traditional light therapy strategy. For example, the photosensitizer excitation light source used in most photodynamic methods is ultraviolet light or visible light, which limits the application of photodynamics in deep tissues. To overcome this shortcoming, researchers have developed photosensitizers excited by near-infrared light and photodynamics mediated by rare-earth-doped upconversion nanomaterials. Howeve...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/06C09K11/62A61K41/00
CPCA61K41/0071C09K11/02C09K11/06C09K11/682C09K2211/188
Inventor 杨黄浩林夏辉宋良李娟
Owner FUZHOU UNIV
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