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3D printing material, neural restoration catheter and preparation method of neural restoration catheter

A technology of 3D printing and printing materials, which is applied in the fields of bioengineering and biomedicine, can solve the problems of poor printing accuracy, achieve the effect of reducing material usage, improving printing accuracy, and improving accuracy

Active Publication Date: 2018-07-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem of poor printing accuracy of continuous DLP3D printing technology, the present invention provides a new type of 3D printing material

Method used

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  • 3D printing material, neural restoration catheter and preparation method of neural restoration catheter
  • 3D printing material, neural restoration catheter and preparation method of neural restoration catheter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 Preparation and use of the nerve repair catheter of the present invention

[0047] (1) Constructing a 3D digital model of the nerve-promoting tube: According to the diameter of the nerve in the body, we built the model of the nerve-promoting tube with inner diameters of 1.5mm, 5mm, and 8.5mm through the three-dimensional model building software;

[0048] (2) Configure printing materials: prepare printing materials, wherein the concentration of methacrylated gelatin (GelMA) is 20%, the concentration of vitamin B12 is 0.1%, and the concentration of photoinitiator LAP is 1%;

[0049] (3) Printing: Add the configured printing materials into the sample pool, start the program and wait for the printing to be completed, then take out the nerve-promoting repair tube;

[0050] (4) Cleaning of the nerve repair tube: soak the printed nerve repair tube in water to remove the photoinitiator and reduce the ultraviolet light through the material, take it out and dry it to...

Embodiment 2

[0051] Embodiment 2 Preparation and use of the nerve repair catheter of the present invention

[0052] (1) Constructing a 3D digital model of the nerve-promoting tube: According to the diameter of the nerve in the body, we built the model of the nerve-promoting tube with inner diameters of 1.5mm, 5mm, and 8.5mm through the three-dimensional model building software;

[0053] (2) Configure printing materials: prepare printing materials, wherein the concentration of polycaprolactone diacrylate (PEGDA) is 20%, the concentration of vitamin B12 is 0.1%, and the concentration of photoinitiator LAP is 1%;

[0054] (3) Printing: Add the configured printing materials into the sample pool, start the program and wait for the printing to be completed, then take out the nerve-promoting repair tube;

[0055] (4) Cleaning of the nerve repair tube: soak the printed nerve repair tube in water to remove the photoinitiator and reduce the ultraviolet light through the material, take it out and dry...

Embodiment 3

[0056] Embodiment 3 Preparation and use of the nerve repair catheter of the present invention

[0057] (1) Constructing a 3D digital model of the nerve-promoting tube: According to the diameter of the nerve in the body, we built the model of the nerve-promoting tube with inner diameters of 1.5mm, 5mm, and 8.5mm through the three-dimensional model building software;

[0058] (2) Configure printing materials: prepare printing materials, wherein the concentration of sodium methacrylated alginate is 5%, the concentration of vitamin B12 is 0.1%, and the concentration of photoinitiator LAP is 1%;

[0059] (3) Printing: Add the configured printing materials into the sample pool, start the program and wait for the printing to be completed, then take out the nerve-promoting repair tube;

[0060] (4) Cleaning of the nerve repair tube: soak the printed nerve repair tube in water to remove the photoinitiator and reduce the ultraviolet light through the material, take it out and dry it to ...

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Abstract

The invention relates to the fields of bioengineering and biomedicine, in particular to a 3D printing material, a neural restoration catheter and a preparation method of the neural restoration catheter. The novel 3D printing material is provided by the invention, substances capable of reducing ultraviolet light transmittance are added into conventional raw materials for biomaterial printing, and thus the 3D printing material can be used for high-precision printing is obtained. Through the material, high-precision biomaterials such as the neural restoration catheter can be prepared by 3D printing equipment.

Description

technical field [0001] The invention relates to the fields of bioengineering and biomedicine, in particular to 3D printing materials, nerve repair catheters and preparation methods thereof. Background technique [0002] At present, various traumas such as compression, stretching, tearing, cutting and other reasons cause partial or complete damage to the nervous system, which leads to loss of function and other neurological diseases. For damaged nerves, the neuronal axons of the nerve can regenerate under the right circumstances. With the development of neurosurgery, especially microneurosurgery, the repair and regeneration of nerve injury has become possible. The current research and clinical application of nerve repair techniques mainly include: direct suture, nerve transplantation (autograft or allograft) and repair through nerve-promoting tubes. For long-distance nerve defects, nerve repair catheters are currently a research hotspot due to their wide range of synthetic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/124B33Y70/00
CPCB33Y70/00
Inventor 苟马玲魏于全陶杰张久盟苟智元
Owner SICHUAN UNIV
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