Unlock instant, AI-driven research and patent intelligence for your innovation.

Double-screw extruder for drug preparation

A twin-screw extruder and extruder technology, applied in the field of continuous processing equipment, can solve problems such as limited temperature control accuracy, drugs that cannot tolerate the temperature, and no cooling system for the barrel, so as to avoid thermal degradation.

Inactive Publication Date: 2018-08-03
杨高品 +1
View PDF9 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the pharmaceutical preparation twin-screw extruders used in industry and academia adopt integral barrel structure, and the barrel has no cooling system. Even a few extruders with cooling system, due to the integral structural design of the barrel, The accuracy of its temperature control is limited
Most of the drugs cannot withstand higher temperatures and are easily degraded and invalidated. Therefore, the above-mentioned integral barrel structure is not conducive to the preparation of temperature-sensitive drugs
In addition, most pharmaceutical preparation twin-screw extruders do not have liquid injection devices and side feeding systems, so liquid and solid pharmaceutical active ingredients and other auxiliaries cannot be added downstream of the extruder, thereby limiting process flexibility and thus limiting range of application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Double-screw extruder for drug preparation
  • Double-screw extruder for drug preparation
  • Double-screw extruder for drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] The present invention will be described in detail below in conjunction with the accompanying drawings and specific implementation examples, but the embodiments of the present invention are not limited thereto.

[0029] see Figure 1-7 As shown, a twin-screw extruder for medicine preparation includes a frame 1, a servo motor 15 and a gear box 12, the motor 15 and the gear box 12 are sequentially fixed on the base 16 installed above the frame 1, the motor 15 and The gear box 12 is connected through the coupling 13, and the machine barrel 7 is connected with the gear box through the coupling part 11, and is fixedly supported on the frame 1 by the machine barrel support 3. Pressure sensor 6 and temperature sensor 4 are installed on 5. The hopper 10 is connected to the barrel of the first zone, the liquid injection device 9 is connected to the barrel of the third zone, the vacuum device 17 is connected to the barrel of the fifth zone, and the side feeding system 18 is conne...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a double-screw extruder for drug preparation and relates to the manner that active drug ingredients, carriers and auxiliaries are continuously added into an extruder and uniformly mixed to prepare drug. The extruder is the double-screw extruder and comprises two rotary screws, wherein each screw is composed of a core shaft and a screw thread element which is mounted on the core shaft in a combining mode. The double-screw extruder comprises a machine barrel which is formed by combining several machine barrel sections and provided with an independent temperature control system. Openings are formed in the specific machine barrel sections according to the process requirements so that operations of vacuumizing, lateral feeding and liquid injecting can be performed.

Description

technical field [0001] The invention relates to a continuous processing equipment for medicine preparation, in particular to a twin-screw extruder for medicine preparation. Background technique [0002] The use of twin-screw extruders for drug preparation is a new technology in the pharmaceutical field, and both the pharmaceutical industry and academia believe that it is becoming an innovative drug delivery technology. Compared with traditional pharmaceutical technology, this technology has the advantages of continuous production, reduced process steps, high repeatability, no solvent, online monitoring and low fixed investment. The preparation of drugs by twin-screw extrusion can be applied to improve the solubility and bioavailability of drugs, prepare sustained and controlled release preparations, prepare localized release preparations, parenteral storage and local drug delivery systems, and mask the bad taste of active ingredients of drugs. [0003] At present, most of t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B30B11/24B30B15/26B30B15/30B30B15/34A61J3/00
CPCB30B11/243A61J3/00A61J2200/20A61J2200/40A61J2200/70A61J2200/72B30B15/26B30B15/30B30B15/34
Inventor 杨高品曹柳
Owner 杨高品