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Mass spectrometer electric field self-tuning method

A self-tuning, electric field technology, applied in the field of mass spectrometry analysis, can solve the problems of signal saturation, low signal-to-noise ratio, and large fluctuation, and achieve the effect of ensuring no signal peak drift, low-concentration signal, and stable signal-to-noise ratio.

Active Publication Date: 2019-12-17
FOCUSED PHOTONICS
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  • Application Information

AI Technical Summary

Problems solved by technology

[0010] 1. Mass spectrometer for ions with different mass-to-charge ratios, V rf It is always a fixed value. For different measured components or different gas concentrations, it cannot achieve the best stability and the lowest detection limit at the same time.
[0011] 2. For low-concentration substances, if the concentration is below 10ppm, the measurement signal-to-noise ratio is low, and the minimum requirement for signal-to-noise ratio cannot be met.
[0012] 3. The low concentration signal is unstable and fluctuates greatly
[0013] 4. When measuring substances with high concentrations, signal saturation is prone to occur at certain mass peak positions

Method used

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  • Mass spectrometer electric field self-tuning method

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Embodiment 1

[0038] According to the method for self-tuning the electric field of a mass spectrometer in an embodiment of the present invention, the method for self-tuning the electric field of a mass spectrometer is:

[0039] The electric field is formed in the quadrupole analyzer; the scanning curve is automatically tuned according to the ion intensity of different fragment ions: when the signal is too strong, such as the signal is saturated, the slope of the scanning curve is gradually increased; when the signal is too low, such as the signal-to-noise ratio If the minimum requirement is not met, gradually reduce the slope of the scan curve; the automatic tuning method is:

[0040] set up R S Is the tuning factor, ΔR S Is the smallest change of tuning factor;

[0041] (A1) Pass in pure gas, measure signal background noise intensity I 0 , Adjust the tuning factor R S Value to record the maximum signal of the instrument as I max , Record the R at this time S Value as the initial value R S0 ;

[...

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Abstract

The invention provides a self-tuning method for a mass spectrometry electric field. The self-tuning method for the mass spectrometry electric field comprises the steps of automatically tuning a scanning curve according to the ionic strength of different fragment ions; when a signal is too strong, gradually increasing the slope of the scanning curve; and when the signal is too weak, gradually reducing the slope of the scanning curve. The self-tuning method has the advantages that the signal is stable, saturation is avoided and the signal-to-noise ratio can reach the requirements.

Description

Technical field [0001] The invention relates to mass spectrometry analysis, in particular to a method for self-tuning the electric field of the mass spectrometer. Background technique [0002] Such as figure 1 As shown, the quadrupole analyzer consists of four rod-shaped electrodes, and a voltage (V rf +V dc ), there is -(V rf +V dc ), where V dc DC voltage, V rf Is the RF voltage. The four rod-shaped electrodes form a quadrupole electric field. The purpose of separating and detecting ion signal intensity is achieved by changing the RF voltage. [0003] according to figure 1 The working principle of the quadrupole analyzer shown is to set the ion motion equation. If the mass is m and the ion with the charge e enters the quadrupole field from the z direction, the motion equation is established according to the relationship between the electric field force and the acceleration. The simplified equation Yes: [0004] [0005] [0006] [0007] among them: [0008] [0009] The curre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/42
CPCH01J49/4215
Inventor 任焱张进伟
Owner FOCUSED PHOTONICS
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