Loading device used for matrix-assisted laser desorptoin ionization flight time mass spectrum

Abstract

The invention discloses a loading device used for matrix-assisted laser desorptoin ionization flight time mass spectrum, comprising a shell formed with a containing chamber, a target loading table located in the containing chamber and a sampling device, wherein the target loading table comprises a body part and a baffle, the sampling device comprises a sampling channel for the body part of the target loading table to enter and exit, a window is arranged on the side wall of the shell, a first circular groove is formed by sinking inward in the inner wall of the window, a groove is formed betweenthe first circular groove and the outer surface of the side wall of the sampling device corresponding to the edge of the entrance of the sampling channel, a sealing member is arranged in the groove,when the body part of the target loading table enters the sampling channel, the corner, close to the sampling device, of the baffle props against the surface of one side of the inner end part of the sealing member. The loading device can ensure vacuum isolation of the containing chamber of the device in the processes of loading and taking out a biological target plate, and can realize effective sealing when relatively greater pressure difference exists between the containing chamber and the sampling channel by adjustment of the structure of the device.

Description

technical field [0001] The invention relates to a loading device. More specifically, it relates to a loading device for matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Background technique [0002] Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF) is a precision high-end analytical instrument. Its ion flight space requires a high vacuum environment, and the environmental vacuum degree can reach 1e-7Torr or even higher. According to the operating requirements of biological experiments, the existing loading device usually includes a holding chamber with an internal vacuum state and a sampling device with a sampling channel that facilitates the entry and exit of the biological target plate. The structure for loading and ejecting the target plate is usually It is called the target loading platform, and the receiving chamber where the target plate enters or ejects the device in a vacuum state must pass through ...

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Problems solved by technology

In addition, according to existing standards, the size of the groove for placing the seal is based on the seal being fully compressed by the contact surfaces on both sides. Although the seal has a certain degree of elasticity, in this case, the amount of compression that the seal can adjust very small or almost zero

[0004] In addition, in the prior art, the isolation and communication between the vacuum containment chamber and the sampling channel are also achieved through the lateral or circular movement of the control mechanism, but the sealing structure itself has no longitudinal compression and adjustment functions. The pressure on the seal depends entirely on the machining accuracy of the corresponding groove of the seal, and the longitudinal adjustment of the seal is also impossible, and when the sealing effect is not good, it is difficult to achieve the ideal isolation and sealing effect through the effective adjustment of the mechanism itself

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