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Application of chicken gall conversion product in preparing medicine for preventing and/ or curing liver fibrosis

A technology of liver fibrosis and transformation products, which is applied in the application field of chicken bile transformation products in the preparation of drugs for the prevention and/or treatment of liver fibrosis, can solve problems such as output barriers, achieve low production costs, abundant sources, and promote The effect of development

Inactive Publication Date: 2018-08-10
SHANGHAI UNIV OF T C M
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional Chinese medicine has a long history of treating chronic liver diseases, and bear bile has the function of protecting the liver. However, due to the production barriers between natural bear bile and artificial bear bile, it has brought unprecedented resistance to the production of bear bile and the development of related industries.

Method used

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  • Application of chicken gall conversion product in preparing medicine for preventing and/ or curing liver fibrosis
  • Application of chicken gall conversion product in preparing medicine for preventing and/ or curing liver fibrosis
  • Application of chicken gall conversion product in preparing medicine for preventing and/ or curing liver fibrosis

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The preparation of embodiment 1 chicken bile transformant

[0033] For the preparation of the chicken gall conversion product of the present invention, refer to an artificial bear bile powder whose publication number is CN104382941B and its preparation method.

[0034] 1. Preparation of chicken gall powder

[0035] Chicken guts are purchased from slaughterhouses. First determine the number and weight of gallbladder. Use 75% alcohol to sterilize part of the chicken gall, and then dissect the bile separately. The taken out bile was freeze-dried for 48 hours to obtain chicken bile powder, which was stored in a desiccator for subsequent use.

[0036] Chicken bile powder is mainly composed of the following components by mass percentage: 40% to 93% of total cholic acid, 4% to 9% of amino acid, and 0.5% to 1% of trace elements; wherein, taurochenodeoxycholic acid ( TCDCA) accounts for 40% to 74% of the mass percentage of chicken gall powder. In addition to the above-menti...

Embodiment 2

[0051] Example 2 Anti-hepatic fibrosis experiment of chicken bile transformant

[0052] Animals: Healthy Wistar rats, half male and half female, weighing 160-180 g, provided by Shanghai Xipuer-Bikay Experimental Animal Co., Ltd.

[0053] experimental method:

[0054] DMN (dimethylnitrosamine) modeling: intraperitoneal injection of 0.5% DMN solution, the injection dose is 2mL / kg body weight, once a day, 3 consecutive days a week, a total of 8 weeks; 2 / 3 of the amount is injected in the first week .

[0055] Normal group: intraperitoneal injection of the same amount of normal saline, once a day, a total of 8 weeks.

[0056] Animal grouping: After 2 weeks of intraperitoneal injection of DMN for modeling, the rats were randomly divided into DMN model group (no administration), low-dose chicken gall conversion group, and high-dose chicken gall conversion group, and each group continued to make models according to DMN Inject 0.5% DMN solution by intraperitoneal injection until th...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to the application of a chicken gall conversion product in preparing a medicine for preventing and / or curing liver fibrosis. According to the application, a liver fibrosis rat model of di-methyl-nitrosamine is used for treating the chicken gall conversion product to reduce liver collagen deposition degree and improve liver inflammatory and fibrotic pathological changes, has the function of liver fibrosis lesion resistance, and can be used for preparing the anti-liver fibrosis medicine. The chicken gall conversion product serves as an active ingredient for restraining and / or reversing liver fibrosis in the anti-liver fibrosis medicine, the mass percent of the chicken gall conversion product is 10%-95%, the suppression and / or reversion of the liver fibrosis can be achieved by improving hepatic cell inflammation and / or improving hepatic cell repair and / or restraining liver fibrosis lesion, and the medical application prospects are wide.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of chicken gall conversion products in the preparation of drugs for preventing and / or treating liver fibrosis. Background technique [0002] Liver fibrosis is the common pathological basis for the development of various chronic liver diseases to cirrhosis. Its essence is the imbalance between the synthesis and degradation of intrahepatic extracellular matrix, which leads to a large amount of extracellular matrix, especially collagen, deposited in the liver. The continuous development of liver fibrosis leads to corresponding organ dysfunction and failure, which seriously endangers life and health. Slowing down, preventing or even reversing liver fibrosis is of great significance to reducing the occurrence of serious complications, improving the quality of life of patients and increasing the survival rate. Therefore, the development of anti-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/57A61P1/16
Inventor 马越鸣吴家胜杨莉王峥涛王天明郑敏刘绍勇
Owner SHANGHAI UNIV OF T C M
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