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Biological 3D printed full-custom skin and preparation method thereof

A 3D printing, fully customized technology, applied in the fields of medical science, prosthesis, additive processing, etc., can solve the problems of production efficiency and treatment effect limitations, to improve the success rate of transplantation and healing effect, high treatment success rate, good The effect of the healing effect

Inactive Publication Date: 2018-08-14
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the further maturity of technology, full-thickness skin with the same properties as human skin can be cultivated. However, most of the current artificial skins are hand-made or flat-printed, which has limitations in production efficiency and therapeutic effect.

Method used

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  • Biological 3D printed full-custom skin and preparation method thereof
  • Biological 3D printed full-custom skin and preparation method thereof
  • Biological 3D printed full-custom skin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A biological 3D printed fully customized skin and a preparation method thereof of the present invention, comprising the following steps in sequence:

[0030] 3D scanning and skin modeling, use a 3D scanner to scan the damaged part of the human skin to obtain the 3D structure of the damaged part of the skin, and then use the software to calculate the various properties of the fully customized skin that needs to be transplanted, including: PDMS base 3D model And skin structure model; establish a skin model that conforms to the three-dimensional structure of the damaged skin, so that the fully customized skin can completely fit the wound, and estimate the number of stem cells needed;

[0031] Cell extraction, extracting 0.1g of human skin tissue, after cleaning, disinfection, weighing, and chopping to obtain the preliminarily treated skin tissue, adding corresponding protease and collagenase to enzymatically hydrolyze the tissue to obtain free skin cell tissue fluid; filter...

Embodiment 2

[0037] A biological 3D printed fully customized skin and a preparation method thereof of the present invention, comprising the following steps in sequence:

[0038] 3D scanning and skin modeling, use a 3D scanner to scan the damaged part of the human skin to obtain the 3D structure of the damaged part of the skin, and then use the software to calculate the various properties of the fully customized skin that needs to be transplanted, including: PDMS base 3D model And skin structure model; establish a skin model that conforms to the three-dimensional structure of the damaged skin, so that the fully customized skin can completely fit the wound, and estimate the number of stem cells needed;

[0039] Cell extraction, extracting 0.2g of human skin tissue, after cleaning, disinfection, weighing, and chopping to obtain the preliminarily treated skin tissue, adding corresponding protease and collagenase for tissue enzymolysis to obtain free skin cell tissue fluid; filtering to obtain c...

Embodiment 3

[0045] A biological 3D printed fully customized skin and a preparation method thereof of the present invention, comprising the following steps in sequence:

[0046] 3D scanning and skin modeling, use a 3D scanner to scan the damaged part of the human skin to obtain the 3D structure of the damaged part of the skin, and then use the software to calculate the various properties of the fully customized skin that needs to be transplanted, including: PDMS base 3D model And skin structure model; establish a skin model that conforms to the three-dimensional structure of the damaged skin, so that the fully customized skin can completely fit the wound, and estimate the number of stem cells needed;

[0047] Cell extraction, extracting 0.3g of human skin tissue, after cleaning, disinfection, weighing, and chopping to obtain the preliminarily treated skin tissue, adding corresponding protease and collagenase for tissue enzymolysis to obtain free skin cell tissue fluid; filtering to obtain c...

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Abstract

The invention relates to the technical field of tissue engineering skin and specifically relates to biological 3D printed full-custom skin and a preparation method thereof. The preparation method comprises two parts of a skin stem cell extraction technology and a skin biological 3D remodeling technology. The skin stem cell extraction comprises the steps: tissue obtaining and treatment, tissue enzymolysis, primary cell culture, subculture and the like. A biological 3D printer is utilized, a three-dimensional scanning modeling technology is utilized, a method of printing raw materials, calculating printing specifications, printing a substrate, printing layer by layer and stacking layer by layer is utilized, full-custom skin completely meeting a specific part and a specific three-dimensionalcharacteristic of the human body can be printed out, complete attachment between artificial skin and wound is ensured, and a transplanting success rate and a healing effect are improved. Meanwhile, the full-custom skin can be applied to research of in-vitro skin models and plays an important role in the aspects of tumor research, medicine, cosmetic testing and the like.

Description

technical field [0001] The invention discloses a fully customized biological 3D printed skin and a preparation method thereof, belonging to the technical field of tissue engineering skin. Background technique [0002] As an important organ of the human body, the skin plays an irreplaceable role in isolating the external environment and protecting the normal operation of the human body. Inflammation, burns, trauma and other causes can damage our skin and pose a huge threat to our health and life. According to actual needs, a method of autologous skin transplantation has appeared, but the low success rate and limited skin sources have always been the defects of this method, which is greatly limited in the healing of large area burns and special patients. [0003] With the development and progress of medical technology, artificial skin technology has emerged. It makes up for the defects of autologous skin transplantation, and only needs to obtain a small amount of skin cells ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/38A61L27/24A61L27/50A61L27/60B33Y10/00B33Y50/02B33Y70/00B33Y80/00
CPCA61L27/24A61L27/3804A61L27/3813A61L27/3895A61L27/50A61L27/60B33Y10/00B33Y50/02B33Y70/00B33Y80/00
Inventor 桑胜波申治中张虎林张益霞张强段倩倩菅傲群冀健龙袁仲云
Owner TAIYUAN UNIV OF TECH
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