A kind of preparation method of phosphonated laminarin

Abstract

The invention discloses a preparation method of phosphorylated laminarin. The preparation method comprises the following steps: (1) weighing laminarin and dipotassium hydroxyethylidene diphosphonate at room temperature and mixing; then adding urea; after uniformly mixing the three components, heating and reacting for 5 to 8h to obtain a mixture; (2) adding distilled water into the mixture obtainedby step (1) and heating to 40 to 60 DEG C; then concentrating and extracting with ethanol; separating and drying to obtain a laminarin phosphorylated product. According to the preparation method disclosed by the invention, dipotassium hydroxyethylidene diphosphonate is used as an organic phosphonic acid acidifying reagent, and the phosphorylated laminarin containing an organic phosphonic acid functional group is obtained through a low-heat solid-phase method, and the content of phosphate groups in a laminarin derivative can be effectively improved, so that the activity of the phosphorylated laminarin is improved. According to the preparation method, a related synthesis preparation method of obtained laminarin hydroxyethylidene diphosphonate is simple and feasible and the cost is low, so that the preparation method is convenient for industrialization and technological popularization; the laminarin can be popularized and applied in the fields including food additives, functional health-care foods, medicines and the like.

Description

technical field [0001] The invention belongs to the technical field of polysaccharide derivatives, in particular to a preparation method of phosphonated laminarin. Background technique [0002] Yantai is located in the Jiaodong Peninsula and has the advantage of rich marine resources. Yantai is rich in seafood resources and is an important kelp breeding production base in China. The water in this sea area is deep and the current is fast. The kelp grown has the characteristics of long body, wide straight part, good color and high quality. Kelp is rich in polysaccharides, has a variety of biological functions and a wide range of biological activities, can resist oxidation, anti-tumor, reduce urine protein, purify blood uric acid, improve blood lipid concentration, and regulate immunity. [0003] The activity of polysaccharides is directly or indirectly affected by its molecular structure, and certain methods can be used to modify the molecular structure of polysaccharides to...

AI Technical Summary

Problems solved by technology

When using inorganic phosphoric acid, inorganic acid anhydride or inorganic phosphate to carry out the reaction, it needs to be carried out under acidic or high temperature conditions, but these conditions are easy to cause the degradation of polysaccharides

However, when phosphorus oxychloride is used, it will be accompanied by side reactions such as crosslinking, which will complicate the product.