Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Stable oteracil potassium suspension and preparation method thereof

A technology of potassium oxonate and preparation method, which is applied in the direction of medical formula, medical preparation of non-effective ingredients, liquid delivery, etc., can solve the problems of injecting mice with soaking cells, prevent precipitation, improve stability, and enhance The effect of dispersion stability

Active Publication Date: 2018-08-28
INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Potassium oxonate, as a urate oxidase inhibitor, is mainly used in biological experiments to construct models of hyperuricemia and gout, so as to screen urate-lowering and gout drugs. Potassium oxinate solution is very difficult to inject mice, soak cells, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Stable oteracil potassium suspension and preparation method thereof
  • Stable oteracil potassium suspension and preparation method thereof
  • Stable oteracil potassium suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of the potassium oxonate stable suspension comprises: taking 1 part of potassium oxonate by weight, then adding β-cyclodextrin whose weight is 2 times that of potassium oxonate, mixing evenly, and then adding zirconia balls, and then put them into the ball mill for 12 hours under the conditions of rotating speed of 500r / min and ball-to-material ratio of 5:1, take them out and pass through a 100-mesh sieve to obtain mixed fine powder of potassium dioxyxonate and β-cyclodextrin; weigh half of the The deionized water of weight part (the total weight part of deionized water is 52 parts), and adding mass ratio to deionized water is the triethanolamine, potassium carbonate and potassium hydroxide mixture of 1:2:4, stirs, obtains homogeneous solution , put the homogeneous solution in a water bath environment at 50°C, stir at a speed of 1000r / min for 30min, then add the mixed fine powder of potassium oxonate and β-cyclodextrin prepared in step 1 while stir...

Embodiment 2

[0034] The preparation method of the potassium oxonate stable suspension comprises: weighing 2 parts of potassium oxonate by weight, then adding β-cyclodextrin whose weight is 2 times that of potassium oxonate, mixing evenly, and then adding zirconia balls, and then put them into the ball mill for 12 hours under the conditions of rotating speed of 500r / min and ball-to-material ratio of 5:1, take them out and pass through a 100-mesh sieve to obtain mixed fine powder of potassium dioxyxonate and β-cyclodextrin; weigh half of the The deionized water of weight part (the total weight part of deionized water is 50 parts), and adding mass ratio to deionized water is the triethanolamine, potassium carbonate and potassium hydroxide mixture of 1:2:4, stirs, obtains homogeneous solution , put the homogeneous solution in a water bath environment at 50°C, stir at a speed of 1000r / min for 30min, then add the mixed fine powder of potassium oxonate and β-cyclodextrin prepared in step 1 while sti...

Embodiment 3

[0037] The preparation method of the potassium oxonate stable suspension comprises: weighing 3 parts of potassium oxonate by weight, then adding β-cyclodextrin whose weight is 2 times that of potassium oxonate, mixing evenly, and then adding zirconia balls, and then put them into the ball mill for 12 hours under the conditions of rotating speed of 500r / min and ball-to-material ratio of 5:1, take them out and pass through a 100-mesh sieve to obtain mixed fine powder of potassium dioxyxonate and β-cyclodextrin; weigh half of the The deionized water of parts by weight (the total parts by weight of deionized water is 60 parts), adding mass ratio to deionized water is the triethanolamine, potassium carbonate and potassium hydroxide mixture of 1:2:4, stirs, obtains homogeneous solution , put the homogeneous solution in a water bath environment at 50°C, stir at a speed of 1000r / min for 30min, then add the mixed fine powder of potassium oxonate and β-cyclodextrin prepared in step 1 whi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a stable oteracil potassium suspension which comprises the following raw materials in parts by weight: 1-3 parts of oteracil potassium, 0.2-1 part of carboxymethylcellulose and50-60 parts of deionized water. Further, the invention provides a preparation method of the stable oteracil potassium suspension. The preparation method comprises the following steps: weighing oteracil potassium in parts by weight, adding the oteracil potassium into deionized water in one half of the weight parts, and uniformly stirring to obtain oteracil potassium dispersion; weighing carboxymethylcellulose in parts by weight, adding the carboxymethylcellulose into deionized water accounting for 1 / 4 of the weight parts, and uniformly stirring to obtain a carboxymethylcellulose solution; adding the prepared carboxymethylcellulose solution into the prepared oteracil potassium dispersion, uniformly stirring, adding the rest deionized water accounting for 1 / 4 of the weight parts, and whirling, so as to obtain the stable oteracil potassium suspension. The oteracil potassium can be uniformly and stably dispersed into the aqueous solution, so that the stable oteracil potassium suspension with excellent dispersion stability and storage simplicity is prepared.

Description

technical field [0001] The invention relates to a suspension. More specifically, the present invention relates to a stable suspension of potassium oxonate, which belongs to the field of biotechnology. Background technique [0002] Potassium oxonate, also known as oteracil potassium, its molecular formula is C 4 h 2 KN 3 o 4 , with a molecular weight of 195.17, is a white crystalline powder, hardly soluble in water, and its molecular structure is as follows: [0003] [0004] Potassium oxonate, as a urate oxidase inhibitor, is mainly used in biological experiments to construct models of hyperuricemia and gout, so as to screen urate-lowering and gout drugs. It is very difficult to inject the potassium oxinate solution into mice, soak the cells, etc. Therefore, how to prepare a stable suspension of potassium oxonate is of great significance to the application of potassium oxonate in medical and pharmaceutical experiments, drug research and development, and the like. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/53A61K47/38
CPCA61K9/10A61K31/53A61K47/38
Inventor 李琦张瑛毓王凤忠李淑英王东晖张丽静王艳
Owner INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com