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A kind of amphiphilic polymer modified by soluble asymmetric phthalocyanine and its synthesis method

A polymer and amphiphilic technology, applied in the field of materials, can solve problems such as use limitations, achieve functional enhancement, enhanced therapeutic effect, and low biological toxicity

Inactive Publication Date: 2020-06-05
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Phthalocyanine, as the leader of the second-generation photosensitizer, has always been favored by people, but its use is limited due to its solubility problem, so we expect to make a kind of phthalocyanine with good solubility and easy modification Phthalocyanine to facilitate the modification of this photosensitizer

Method used

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  • A kind of amphiphilic polymer modified by soluble asymmetric phthalocyanine and its synthesis method
  • A kind of amphiphilic polymer modified by soluble asymmetric phthalocyanine and its synthesis method
  • A kind of amphiphilic polymer modified by soluble asymmetric phthalocyanine and its synthesis method

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Embodiment Construction

[0020] The soluble asymmetric phthalocyanine amphiphilic block polymer polyethylene glycol monomethyl ether-polylactic acid (mPEG-b-PLA-S-S-ZnPC) of the present invention has different affinities to aqueous solutions, so it can self-assemble to form nano Micellar particles, the advantage of this polymer is that it is not limited to its own photodynamic therapy, and can also be combined with chemotherapy drugs such as doxorubicin to treat cancer synergistically.

[0021] Synthesis of 3-ethoxyhydroxy-10,17,24-tridecyloxyzinc phthalocyanine (ZnPC-OH)

[0022] The synthesis route of 3-ethoxyhydroxy-10,17,24-tridecyloxyzinc phthalocyanine (ZnPC-OH) is shown in figure 1 . Take a cooled single-necked round bottom flask after high temperature treatment, add 4-decyloxyphthalonitrile (0.568g, 2mmol) and 4-[2-(2-ethoxypyran)]phthalonitrile (0.182g , 0.67mmol), then add 10ml of n-amyl alcohol, react for 24h, remove the protecting group, and then purify to obtain 42mg of the blue-green p...

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Abstract

The invention relates to an amphipathic organic polymer modified by asymmetric phthalocyanine, and the amphipathic organic polymer is an organic polymer material. The asymmetric phthalocyanine modified amphipathic organic polymer is characterized in that a hydrophilic part is methoxy polyethylene glycol, an oleophilic part is polylactic acid and phthalocyanine, and the hydrophilic part and the oleophilic part are bonded through disulfide bonds; amphipathic molecules can be used for treating cancer, and belongs to the field of organic polymers. The method comprises the following steps: firstly,synthesizing soluble asymmetric zinc phthalocyanine; ring-opening and polymerizing L-lactide by using the methoxy polyethylene glycol to form a block polymer; and enabling the hydrophilic part and the oleophilic part to be bonded through the disulfide bonds to form the amphipathic polymer. When the polymer is in an aqueous solution, the polymer can be self-assembled to form micelle, chemotherapeutic drugs can be wrapped inside the micelle, and the micelle is used as a drug carrier, and the polymer can also make a passive response to cancer cells, so that photodynamic therapy is achieved. In general, the polymer can also be used as a unit treatment drug for chemotherapy and photodynamic therapy.

Description

technical field [0001] The invention belongs to the field of materials, and particularly relates to an amphiphilic polymer modified by soluble asymmetric phthalocyanine and a synthesis method. The amphiphilic polymer can self-assemble into micelles in aqueous solution. [0002] technical background [0003] As cancer has become one of the biggest threats to people's life and health, finding effective means of treating cancer has become the focus of people's research. At present, compared with traditional chemotherapy, photodynamic therapy has low biological toxicity and has attracted people's attention. As an important component in photodynamic therapy, photosensitizers have always been the focus of people's research. Phthalocyanine, as the leader of the second-generation photosensitizer, has always been favored by people, but its use is limited due to its solubility problem, so we expect to make a kind of phthalocyanine with good solubility and easy modification Phthalocya...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/91C08G63/664C08G63/78A61K9/107A61K41/00A61K47/34A61P35/00
CPCA61K9/1075A61K41/0071A61K47/34C08G63/664C08G63/78C08G63/912
Inventor 高波段潜郭善雷李东霓李艳辉张昊天
Owner CHANGCHUN UNIV OF SCI & TECH