Preparation method and application of quercetin lipidosome

A technology of quercetin lipid and quercetin, which is applied in the field of preparation of quercetin liposomes, can solve the problems of reducing the anti-tumor effect of quercetin, difficult to absorb, hemolysis of human body, etc., and achieve the reduction of morphological and pathological changes, The effect of improving the general condition

Inactive Publication Date: 2018-09-04
GUILIN MEDICAL UNIVERSITY
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  • Abstract
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Problems solved by technology

Because quercetin is insoluble in water, it is difficult to absorb, which greatly limits its absorption, administration and bioavailability in the body
Phase I and II clinical trials abroad have confirmed that quercetin can inhibit the progression of various tumors in vivo. However, its solvent, dimethyl sulfoxide, can cause hemolysis, liver and kidney damage, and unpleasant odor, which limits the use of quercetin. in clinical
One of the ways to solve this problem is to chemically modify quercetin, however, this requires a multi-step chemical reaction, the structure of the modified quercetin is unstable, and the anti-tumor effect of quercetin is reduced

Method used

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  • Preparation method and application of quercetin lipidosome
  • Preparation method and application of quercetin lipidosome
  • Preparation method and application of quercetin lipidosome

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experiment example

[0020] Experimental example: preparation and application of quercetin liposome

[0021] 1 Materials and methods

[0022] 1.1 Experimental materials and instruments

[0023] 1.1.1 Experimental animals

[0024] Sixty-five healthy adult male SD rats of SPF grade, weighing 190-220 g, aged 6-8 weeks, were provided by the Animal Laboratory of Guilin Medical College (SPF grade) and raised in the Animal Laboratory of Guilin Medical College. Breeding conditions: room temperature 18-25°C, keep air circulation, relative humidity 55-70%, 12h light maintenance, simulate day and night cycle, clean the cage and change the bedding every day to keep the living environment clean and dry.

[0025] 1.2 Experimental method

[0026] 1.2.1 Preparation of quercetin liposomes

[0027] This experiment was prepared by rotary evaporation method, the specific preparation steps are as follows:

[0028] (1) Weigh quercetin: cholesterol: lecithin: polyethylene glycol 4000 in a weight ratio of 6:4:13:1 i...

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Abstract

The invention discloses a preparation method and application of a quercetin lipidosome. The preparation method comprises the steps of using a nano-liposome to encapsulate water-fast quercetin, and preparing into a quercetin lipidosome. The influence of the quercetin lipidosome (LQ) on the expressions of diabetic rat kidney advanced glycation end products (AGES), a receptor thereof (RAGE) and TGF-teta 1 , and the influence of the LQ on DM rat kidney are researched through experiments, the LQ is compared with aminoguanidine (AG), and the intervention of the LQ on DM kidney is discussed. Experiments show that the LQ can be used for reducing the morphologic pathology change of diabetic nephropathy to a certain degree and improving the general condition of STZ DM rats, and has a function of decreasing blood sugar. The preparation method and the application of the quercetin lipidosome lay a foundation for the next clinic application research of the quercetin lipidosome, and meanwhile, provide a new idea and a theoretical basis for exploring clinic traditional Chinese medicine treatment of DM.

Description

technical field [0001] The invention relates to quercetin, in particular to a preparation method and application of quercetin liposome. Background technique [0002] Quercetin is a natural flavonoid compound widely found in vegetables and fruits. Quercetin has anti-tumor, anti-inflammation, anti-oxidation effects, and affects the activity of various enzymes, so it is a potential chemotherapy drug. Because quercetin is insoluble in water, it is difficult to absorb, which greatly limits its absorption, administration and bioavailability in the body. Phase I and II clinical trials abroad have confirmed that quercetin can inhibit the progression of various tumors in vivo. However, its solvent, dimethyl sulfoxide, can cause hemolysis, liver and kidney damage, and unpleasant odor, which limits the use of quercetin. in the clinic. One of the ways to solve this problem is to chemically modify quercetin, however, this requires multi-step chemical reactions, and the modified querce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/352A61P35/00A61P13/12A61P3/10
CPCA61K31/352A61K9/127A61P3/10A61P13/12A61P35/00
Inventor 顾生玖朱开梅马授权蒋运生许有瑞
Owner GUILIN MEDICAL UNIVERSITY
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