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Toll-like receptor agonist mouthwash for preventing and treating oral ulcer

A technology of receptor agonist and oral ulcer, which is applied in the field of oral care, can solve the problems of high timeliness, easy recurrence, and large side effects, and achieve the effect of strong functionality, short treatment time, and quick onset

Inactive Publication Date: 2018-09-07
睿欧生物科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first few types of local treatment drugs have high timeliness, but are prone to relapse; the latter types of systemic treatment drugs are generally more thorough in treatment, but have relatively large side effects

Method used

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  • Toll-like receptor agonist mouthwash for preventing and treating oral ulcer
  • Toll-like receptor agonist mouthwash for preventing and treating oral ulcer
  • Toll-like receptor agonist mouthwash for preventing and treating oral ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A Toll-like receptor agonist mouthwash for preventing and treating oral ulcers, the weight percentage of its raw materials is: Pam3CSK4 1.51×10 -8 %, polyinosinic acid 1.0%, imiquimod 2.76×10 -10 %, CpG-ODN 1.4×10 -7 %, 0.05% chlorhexidine acetate, 0.3% cyclamate, 7.0% moisturizing agent, 2.0% peppermint essential oil, 0.03% zinc citrate, 0.06% thymol, and the balance is distilled water; the moisturizing agent is a mixture of sorbitol and glycerin Mixture, the mixing weight ratio is 5:1.

[0025] Among them, the preparation method is to mix the raw materials according to the corresponding weight ratio, stir fully to dissolve evenly, pour into the pasteurization instant sterilizer, heat to 95°C, and maintain it for 20 seconds to complete the sterilization. The solution should be quickly packed into a sterilized glass bottle and sealed while hot, so as to obtain the Toll-like receptor agonist mouthwash for preventing and treating oral ulcers.

Embodiment 2

[0027] A Toll-like receptor agonist mouthwash for preventing and treating oral ulcers, the weight percentage of its raw materials is: Pam3CSK4 1.51×10 -8 %, polyinosinic acid 3.0%, imiquimod 2.76×10 -10 %, CpG-ODN 1.4×10 -7 %, 0.03% chlorhexidine acetate, 0.4% cyclamate, 6.0% humectant, 1.0% peppermint essential oil, 0.04% zinc citrate, 0.08% thymol, and the balance is distilled water; all the other contents are the same as in Example 1.

Embodiment 3

[0029] A Toll-like receptor agonist mouthwash for preventing and treating oral ulcers, the weight percentage of its raw materials is: Pam3CSK4 1.51×10 -8 %, polyinosinic acid 1.0%, imiquimod 2.76×10 -10 %, CpG-ODN 1.4×10 -7 %, 0.01% chlorhexidine acetate, 0.2% cyclamate, 6.0% humectant, 2.0% peppermint essential oil, 0.03% zinc citrate, 0.04% thymol, and the balance is distilled water; all the other contents are the same as in Example 1.

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Abstract

The invention discloses Toll-like receptor agonist mouthwash for preventing and treating oral ulcer. The mouthwash is mainly prepared from raw materials as follows: triacyl lipopeptide, polyinosinic acid-polycytidylic acid, imiquimod, non-methylated oligodeoxynucleotide, chlorhexidine acetate, sodium cyclamate, a moisturizer, mint essential oil, zinc citrate, thymol and water. The Toll-like receptor agonist mouthwash comprises scientifically matched and coordinated raw materials and has inflammation diminishing and sterilization functions, Toll-like receptor agonists in the raw materials regulate local immune functions of organisms, enhance cell proliferation and repair capacity of oral mucosa and promote healing of oral ulcer, and the effect of treating symptoms and root causes is realized.

Description

technical field [0001] The invention belongs to the technical field of oral care, in particular to a Toll-like receptor agonist mouthwash for preventing and treating oral ulcers. Background technique [0002] Oral ulcer is a common superficial ulcer injury that occurs on the oral mucosa. It is mostly seen in the inner lip of the oral cavity, tongue, tongue abdomen, buccal mucosa, vestibular groove, soft palate, etc. Single or multiple, rice grain to soybean-sized, round or oval ulcers occur, and the surface is covered with gray or yellow Pseudomembrane, the ulcer surface is concave, and the surrounding mucosa is red, swollen and congested. Irritant foods, drugs, changes in hormone levels, local trauma, mental stress, and lack of vitamins or trace elements can all cause oral ulcers. The onset is not limited by age, and women are slightly more than men. Ulcers are self-limiting and can heal themselves in about 10 days. If oral ulcers occur frequently or come one after anothe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/60A61K8/64A61P1/02A61Q11/00
CPCA61K8/4946A61K8/606A61K8/64A61P1/02A61Q11/00
Inventor 孙永帅苏绍波
Owner 睿欧生物科技(上海)有限公司
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