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Process for preventing reduction of gelatin's freezing force during the sol process of traditional Chinese medicine soft capsules

A process method and technology of soft capsules, which are applied in capsule delivery, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of high gelling force, low gelling force, and high viscosity of the rubber skin, and achieve the shape Beautiful, reduce the drop of freezing force, and increase the effect of vacuum degree

Active Publication Date: 2020-11-13
JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine extract preparation is relatively viscous and has high requirements on the gelling force of the rubber. The higher the sol temperature and the longer the sol time, the lower the gelling force of the rubber.

Method used

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  • Process for preventing reduction of gelatin's freezing force during the sol process of traditional Chinese medicine soft capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Chinese traditional medicine soft capsule sol traditional process.

[0027] 1. Prepare red iron oxide and black iron oxide suspensions: Weigh an appropriate amount of purified water and put it in a clean container, add red iron oxide and black iron oxide, stir evenly to obtain solution ①, and set aside. The mass ratio of the black iron oxide, red iron oxide and purified water in the glue solution is: black iron oxide 0.18, red iron oxide 0.14, purified water 0.95.

[0028] 2. Put purified water, glycerin, and polyethylene glycol-400 into the glue tank, turn on the stirring paddle, open the steam valve, and start heating. The quality of the purified water, glycerin and polyethylene glycol-400 in the glue formula is: purified water 37, glycerin 15.3, polyethylene glycol-400 3.8.

[0029] 3. When the temperature in the tank reaches 40°C, add gelatin and sorbitol for capsules. Continue to heat up to 50°C, and put into the solution ①. Continue to heat up unt...

Embodiment 2

[0032] Embodiment 2: The technical method of preventing gelatin's gelling power from reducing during the sol process of traditional Chinese medicine soft capsules.

[0033] 1. Prepare black iron oxide and red iron oxide suspensions: Weigh an appropriate amount of purified water and put it in a clean container, add black iron oxide and red iron oxide, stir evenly to obtain solution ①, and set aside. The mass ratio of the black iron oxide, red iron oxide and purified water in the glue formula is: black iron oxide 0.18, red iron oxide 0.14, purified water 0.95.

[0034] 2. Put purified water, glycerin, and polyethylene glycol-400 into the glue tank, turn on the stirring paddle, open the steam valve, and start heating. The mass ratio of purified water, glycerin, and polyethylene glycol-400 in the glue formula is: purified water 37, glycerin 15.3, polyethylene glycol-400 3.8.

[0035] 3. When the temperature in the tank reaches 60°C, add gelatin and sorbitol for capsules, and add so...

Embodiment 3

[0038] Embodiment 3: The technological method that prevents gelatin's freezing force from reducing during the sol process of traditional Chinese medicine soft capsule.

[0039] 1. Prepare black iron oxide and red iron oxide suspensions: Weigh an appropriate amount of purified water and place it in a clean container, add black iron oxide and red iron oxide, stir well to obtain solution ①, and set aside. The mass ratio of the black iron oxide, red iron oxide and purified water in the glue formula is: black iron oxide 0.15, red iron oxide 0.17, purified water 0.5.

[0040] 2. Put purified water, glycerin, and polyethylene glycol-400 into the glue tank, turn on the stirring paddle, open the steam valve, and start heating. The mass ratio of purified water, glycerin, and polyethylene glycol-400 in the glue formula is: purified water 35.38, glycerin 20, polyethylene glycol-400 3.

[0041] 3. When the temperature in the tank reaches 60°C, add gelatin for capsules, sorbitol, solution ...

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Abstract

The invention discloses a technique for preventing the congelation capacity of gelatin from reducing in the gelatin dissolving process of traditional Chinese medicine soft capsules. The technique comprises the steps that black ferric oxide and red iron oxide suspension is prepared, wherein black ferric oxide and red iron oxide are added into purified water, the materials are stirred to be uniform,and a solution 1 is obtained for use; purified water, glycerinum and polyethylene glycol-400 are put into a gelatin dissolving tank, a stirring paddle is started, a steam valve is switched on, and water bath heating is carried out; when the temperature in the tank reaches 60 DEG C to 85 DEG C, gelatin for the capsules, sorbitol, the solution 1 and sodium pyrosulfite are put in the tank, the materials are stirred to be uniform, and steam is stopped after heating continues to be carried out; vacuumizing is carried out till bubbles are basically extracted out, and the stirring paddle and a vacuum valve are switched off; gelatin placing is carried out, wherein gelatin liquid is placed in an insulation barrel after being filtered, heat preservation is carried out regularly for pelleting. According to the technique, reduction of the congelation capacity of the gelatin is reduced by controlling the gelatin content, the water content, the material adding sequence, the heating temperature, theheating time and the heat preservation time, the sealing rate is obviously increased during pelleting of the traditional Chinese medicine soft capsules, the phenomena of content seepage, gelatin skinadhesion and the like are avoided, and the quality can be stable and controllable.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine soft capsules, in particular to a process method for preventing gelatin from reducing gelatin force during the colloidal process of traditional Chinese medicine soft capsules. Background technique [0002] Soft capsules, also known as soft gelatin pills, are round, oval, fish-shaped, tube-shaped, etc. They are oils or non-water-soluble liquids or suspensions that do not dissolve gelatin, etc., sealed in the capsule shell. Formed preparations. Drugs that are small in dosage, insoluble in water, difficult to absorb in the digestive tract, and unstable to light, humidity and heat, and easy to oxidize can be dissolved in appropriate oil to make soft capsules, which not only increases the digestive tract Absorption improves the curative effect, and the stability is good, and the dosage is accurate, which solves the disadvantages of difficulty in entrance and poor taste for users. [0003] ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/10A61K47/02
CPCA61K9/4816A61K9/4825A61K9/4833
Inventor 殷书梅夏月刘学鑫林新艳李吉峰王玫
Owner JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD