Fluid hemostatic adhesive as well as preparation method and application thereof

A technology for fluid and glue products, applied in the field of fluid hemostatic glue and its preparation, can solve problems such as tissue irritation and influence on wound healing, enhance the speed of gel formation and gel strength, improve wound closure and hemostatic effects, and is easy to operate Effect

Active Publication Date: 2018-09-07
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this kind of fluid matrix has a certain clinical history, it is a kind of foreign body to the human body after all, and high levels can stimulate tissues and affect wound healing

Method used

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  • Fluid hemostatic adhesive as well as preparation method and application thereof
  • Fluid hemostatic adhesive as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A fluid hemostatic glue, comprising a hemostatic effective component and a fluid matrix, the hemostatic effective component includes component A, component B and component C, wherein component A is 0.5g gelatin, and component B is 0.5g α-glycerin Sodium Phosphate, Component C is 0.5g polylysine, the fluid base consists of 10g saline and 0.5mg glycerin. Wherein the jelly strength of gelatin is 200 Bloom / g, and the source of gelatin is pig source.

[0036] The preparation method of the fluid hemostatic gel is as follows: Weigh 0.5g gelatin, 0.5g α-sodium glycerophosphate and 0.5g polylysine in a container, put in an ice bath, keep the temperature at 2°C, add 10g normal saline, and weigh another Add 0.5mg of glycerin into a container, stir to make it evenly mixed, take it out, put it into a container, and irradiate to obtain a fluid hemostatic gel product, which is stored at low temperature for future use.

Embodiment 2

[0038] A fluid hemostatic glue, comprising a hemostatic effective component and a fluid matrix, the hemostatic effective component includes component A, component B and component C, wherein component A is 0.5g gelatin, and component B is 0.5g α-glycerin Sodium Phosphate, Component C is 0.5g polylysine, the fluid base consists of 10g saline and 0.5mg glycerol. Wherein the jelly strength of gelatin is 200 Bloom / g, and the source of gelatin is pig source.

[0039]Wherein the gelatin of component A is modified gelatin, and the preparation method of the modified gelatin is: weigh 1g of gelatin, dissolve it in 20ml of deionized water, add 0.0125g of EDC and NHS, stir and react at 30°C for 3h, Add ethanol to soak and wash, repeat three times, pre-freeze at -80°C, and freeze-dry using a low-temperature and low-pressure freezer to obtain modified gelatin.

[0040] The preparation method of the fluid hemostatic gel is as follows: Weigh 0.5g of the above-mentioned modified gelatin, 0.5g...

Embodiment 3

[0042] A fluid hemostatic gel, comprising a hemostatic effective component and a fluid matrix, the hemostatic effective component includes component A, component B and component C, wherein component A is 1 g of gelatin, and component B is 0.6 g of β-glycerophosphate Sodium, Component C was 0.6 g polyethyleneimine, and the fluid base consisted of 11 g saline and 2.2 mg sodium lauryl sulfate. Wherein the jelly strength of gelatin is 300 Bloom / g, and the source of gelatin is pig source.

[0043] Wherein the component A gelatin is modified gelatin, the preparation method of the modified gelatin is: weigh 2g of gelatin, dissolve it in 20ml of deionized water, add 0.0250g of EDC and NHS, and stir and react at 25°C for 2.5h , add ethanol to soak and wash, repeat three times, pre-freeze at -80°C, and freeze-dry using a low-temperature and low-pressure freezer to obtain modified gelatin.

[0044] The preparation method of the fluid hemostatic gel is as follows: Weigh 1g of the above-m...

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PUM

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Abstract

The invention discloses a fluid hemostatic adhesive as well as a preparation method and application thereof. The fluid hemostatic adhesive comprises a hemostatic effective component and a fluid matrix, wherein the hemostatic effective component is prepared from a component A, a component B and a component C; the component A is gelatin, the component B is sodium glycero-phosphate, and the componentC is polylysine and/or polyethyleneimine; a mass ratio of the component A to the component B to the component C is (1 to 6):(1 to 2):1. The fluid hemostatic adhesive provided by the invention can bestored under a fluid state and requires not to be mixed before using, the operation is simple and convenient, the operation time is greatly shortened, and rapid gelatinization can be realized after the fluid hemostatic adhesive is applied to a human body; meanwhile, the content of an assistant in the fluid hemostatic adhesive is low, and good fluidity and a good hemostatic effect are obtained; further, modified grafting treatment is carried out on the gelatin, so that the strength of the fluid hemostatic adhesive is improved, the adhesion between the fluid hemostatic adhesive and a wound can be remarkably improved, and the hemostatic effect can be further improved.

Description

technical field [0001] The invention relates to the field of hemostatic materials, in particular to a fluid hemostatic glue and its preparation method and application. Background technique [0002] For wounds with diffuse bleeding on uneven surfaces or hard-to-reach deep or narrow areas, commonly used sponge or yarn-like hemostatic materials are difficult to achieve sufficient wound coverage, so flowable hemostatic materials are required. The fluid hemostatic material can shape itself according to the shape of the wound to achieve full contact, and has a good effect on the hemostasis of the above-mentioned special wound. [0003] The fluid hemostatic materials currently on the market mainly include Floseal Haemostatic Matrix of Baxter Company and Surgiflo Haemostatic Matrix of Ethicon Company. Among them, Floseal HaemostaticMatrix is ​​a kit for making hemostatic gelatin paste. The gelatin paste was made by first preparing a thrombin solution and then transferring the gela...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/10A61L24/06
CPCA61L24/046A61L24/06A61L24/104A61L2400/04C08L77/04C08L39/02
Inventor 林丽敏邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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