Lenalidomide gastric retention sustained release tablet and preparation method thereof
A technology for lenalidomide and sustained-release tablets, which is applied in the field of lenalidomide gastroretentive sustained-release tablets and the preparation thereof, can solve the problems of unfavorable formulation stability, unfavorable production, poor stability and the like, and achieves high drug bioavailability , Small side effects, high compliance effect
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[0048] Example 1
[0049]
[0050] Information on release enhancers and sustained release materials:
[0051] Product name
[0052] Lenalidomide is B crystal form, the weight average molecular weight of hydroxypropyl methylcellulose K200M is about 1,200,000. Tablet preparation method: Weigh the above raw materials except magnesium stearate, and mix them evenly after passing through a 60 mesh sieve. , Then add magnesium stearate to mix properly and compress into tablets, the tablet hardness is 9~10kg / cm 2 , Tablet density 0.991g / cm 3 .
[0053] Example 1 Floating performance of gastric floating sustained-release tablets: The tablets float quickly after being put into the dissolution cup, and continue to float in the dissolution medium for at least 24 hours.
[0054] The release measurement results of the lenalidomide gastric retention sustained-release tablets prepared according to Example 1:
[0055] Time(h)
[0056] The test results show that lenalidomide gastric retention susta...
Example Embodiment
[0057] Example 2
[0058]
[0059]
[0060] Information on release enhancers and sustained release materials:
[0061] Product name
[0062] Lenalidomide is in the A crystal form, and the weight average molecular weight of hydroxypropyl methylcellulose K250 is about 200,000. Preparation method: weigh the above raw materials except sodium stearyl fumarate, and mix them evenly after passing through a 60 mesh sieve. , Add sodium stearyl fumarate properly and mix it into tablets, the tablet hardness is 3~4kg / cm 2 , Tablet density
[0063] 0.755g / cm 3 .
[0064] Example 2 Floating performance of gastric floating sustained-release tablets: The tablets float quickly after being put into the dissolution cup, and continue to float in the dissolution medium for at least 24 hours.
[0065] The release measurement results of the lenalidomide gastric retention sustained-release tablets prepared according to Example 2:
[0066] Time(h)
[0067] The test results show that lenalidomide gastric re...
Example Embodiment
[0068] Example 3
[0069]
[0070] Information on release enhancers and sustained release materials:
[0071]
[0072]
[0073] Lenalidomide is crystalline form II, and the weight average molecular weight of hydroxypropyl methylcellulose K750 is about 250,000. Preparation method: Weigh the above-mentioned raw and auxiliary materials except talc, pass through a 60-mesh sieve and mix well, then add talc The powder is properly mixed and compressed into tablets, the tablet hardness is 5~6kg / cm 2 , Tablet density 0.949g / cm 3 .
[0074] Example 3 Floating performance of gastric floating sustained-release tablets: The tablets float quickly after being put into the dissolution cup, and continue to float in the dissolution medium for at least 24 hours.
[0075] The release determination results of the lenalidomide gastric retention sustained-release tablets prepared according to Example 3:
[0076] Time(h)
[0077] The test results show that lenalidomide gastric retention sustained-release t...
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