A kind of method utilizing microchannel reaction device to prepare rifampicin

A technology of channel reaction device and microchannel reaction, which is applied in the direction of organic chemistry, can solve the problems of high price and the impact of cost on income, and achieve the effects of short reaction time, saving raw material costs, low toxicity and pollution
CN108516982BActive Publication Date: 2021-04-30NANJING TECH UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING TECH UNIV
Publication Date
2021-04-30

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Abstract

The invention discloses a method for preparing rifampicin by using a microchannel reaction device. Through a microchannel reactor, rifamycin S is used as a raw material to undergo cyclization, hydrolysis, condensation and crystallization processes without post-treatment process, and directly obtains Rifampicin crude. The invention realizes complete continuous production of rifampicin, has high yield, low cost, high profit, environmental protection, energy saving and high efficiency, and is suitable for industrial application.
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Description

technical field

[0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a method for preparing rifampicin by using a microchannel reaction device. Background technique

[0002] Rifampicin was invented in 1965. The discovery of rifampicin brought about a major leap forward in the treatment of tuberculosis. Some experts spoke highly of the anti-tuberculosis effect of rifampicin and believed that the anti-tuberculosis treatment has now entered the era of rifampicin. , and believed that tuberculosis, which used to be treated with surgery, could be controlled without surgery with rifampicin.

[0003] In the "preparation method of high-quality rifampin" disclosed in Chinese patent 101486716A, rifamycin S sodium salt first generates N-tertidine-1,3-oxazine (5,6-C) rifamycin, and then 1-Methyl-4-amino-piperazine reacts to form rifampicin. Due to the different solvents of the reaction, it is necessary to obtain the crude product of N-...

Claims

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