32results about How to "Short process reaction time" patented technology

The invention discloses an acidic iron-containing wastewater recycling system comprising a pickling wastewater storage pool, wherein the pickling wastewater storage pool is connected with a neutral oxidation reaction tank through a raw water acid proof pump, and a stirrer, a 1# online pH meter and a 1# online ORP (oxidation reduction potential) meter are fixed in the neutral oxidation reaction tank; an alkali liquor storage tank is connected with the neutral oxidation reaction tank through a 1# metering pump; a flocculant storage tank is connected with the neutral oxidation reaction tank through a 2# metering pump; the neutral oxidation reaction tank is connected with a settling tank through a slurry pump, the settling tank is connected with a sludge concentration tank, and a supernatant drain pipe is further connected to the settling tank; the sludge concentration tank is connected with a high pressure plate frame filter press through a high pressure slurry pump; and the neutral oxidation reaction tank is further connected with a blower. The invention further discloses an in situ modification method for treating wastewater by the acidic iron-containing wastewater recycling system. By adopting the acidic iron-containing wastewater recycling system disclosed by the invention, more than 55% of Fe3O4 can be stably prepared and recycled through in-situ reaction in an acidic wastewater neutralization tank under normal temperature and normal pressure conditions.

The invention belongs to preparation of compound products of fine chemical engineering and particularly relates to a preparation method of 2-br-4-fluoacetanilide, which comprise the steps of: acetylation: adding para-fluoro aniline and glacial acetic acid into a reaction flask, heating to 50 DEG V, dropping acetic anhydride, carrying out reaction for 1-3h under the condition of 55-100 DEG C to prepare an intermediate para-fluoro acetanilide; and (2) bromination: dropping bromine at 45-55 DEG C, carrying out reaction for 1-3h under the condition of 50-60 DEG C, then dropping hydrogen peroxide at 40-55 DEG C, carrying out reaction for 1-3h under the condition of 50-60 DEG C, decolorizing and crystallizing with sodium hydrogensulfite, recrystallizing with an ethanol water solution to obtain a finished product of the 2-br-4-fluoacetanilide. The 2-br-4-fluoacetanilide has a chemical reaction formula shown in the specification, the whole process is shorter in reaction time and simple in operation, the reaction conversion rate for the acetylation and the bromination is up to above 90%, a finally obtained product has high purity, and the preparation method is suitable for enlarged industrial production; and thus, the production cost is reduced.

The invention relates to a process for preparing oxidized wax from coal wax. The process comprises the following steps of preparing for a raw material, namely F-T coal wax, adding F-T coal wax into a three-neck flask, gradually heating to 100 DEG C and melting the F-T coal wax; then, adding a catalyst, wherein the weight of the catalyst accounts for 0.1-1.0% of the weight of the F-T coal wax; and introducing 0.2-0.8L/h oxygen gas to each gram of F-T coal wax, controlling the reaction temperature within 125-160 DEG C at the stage, reacting for 3-8 hours, then, taking out the product while the product is hot, sampling and analyzing. According to the process, the oxidized wax is prepared from the F-T coal wax instead of the traditional wax, so that the burden of petroleum resource shortage is relieved, and the economic additional value of the coal wax is increased; materials such as a heavy metal ionic catalyst, nitrogen shielding gases, a water-carrying agent and polymerization additives are not used; the reaction time is short, the process is simple and convenient to operate, the prepared oxidized wax product is light in color and smell, and the acid value and saponification value of the prepared oxidized wax product meet the requirements of the SASOLWAX A28 index of south Africa; and no special processing equipment is required in the process.

The invention discloses a method for continuously preparing an olaparib intermediate by a microchannel modular reaction device. The method comprises the following steps: performing reaction on a dichloromethane solution of 3-hydroxyisobenzofuran-1(3H)-ketone and a dichloromethane solution of dimethyl phosphate in a first microreactor, and performing liquid separation to obtain effluent of (3-oxo-1,3-dihydroisobenzyfuran-1-yl)dimethyl phosphate; performing reaction on the effluent, a dichloromethane solution of 2-fluorine-5-formyl benzene nitrile and a dichloromethane solution of triethylaminein a second microreactor to generate reaction liquid of 2-fluorine-5-(3-oxo-3H-isobenzofuran-1-yl methylene)benzyl cyanide; and performing reaction on the reaction liquid and a homogenous mixed solution which is obtained by stirring an ethanol solution of sodium hydroxide and hydrazine hydrate in a third microreactor and treating the effluent to obtain the olaparib intermediate 2-fluorine-5-[(4-oxo-3,4-dihydrodiazene-1-yl-)methyl]benzoic acid.

The invention provides a green synthesis technique of p-chloro-m-cresol, which comprises the following step: reacting by using m-cresol as a raw material, tetrachloroethylene as a solvent and sulfuric chloride as a chlorinating agent to prepare the p-chloro-m-cresol, wherein the mole ratio of the m-cresol to the tetrachloroethylene is 1:(0.5-1.5), and the mole ratio of the m-cresol to the sulfuric chloride is 1:(0.9-1.1).Compared with the prior art, the technique provided by the invention has the advantages of short reaction time, high solvent recovery rate, clean and environment-friendly production process and high degree of automation, and the m-cresol conversion rate after the reaction finishes is up to 98%; and thus, the technique has favorable industrialization prospects.

The invention relates to a method for synthesizing an esterified wax, in particular to a method for synthesizing an esterified wax from a microcrystalline wax used as a raw material through oxidation and esterification in one step. The product prepared by adopting the method can partially replace the natural carnauba wax and has the general formula of Cn-1H2n +1COOCmH2m-1 (n=30 to 60, and m=18 to 24), the acid value of 2-10mgKOHg/ and the esterification value of 70-86mgKOH/g. The method for synthesizing the esterified wax comprising the following steps: adding the microcrystalline wax and a high-carbon alcohol (CnH2n +1OH, wherein n=8 to 24) at the mass ratio of 5-20:1 into a three-mouth flask, heating to melt the microcrystalline wax, adding weak-acid esterification catalyst, introducing quantitative oxygen, controlling reaction temperature, taking out the product while the product is hot after the reaction of a certain period of time finishes, and weighting. The product synthesized by adopting the method has a higher esterification value and a lower acid value than the product synthesized by steps.

The invention discloses a method for continuously preparing a rosuvastatin intermediate by a micro-channel modular reaction device. The method includes the steps: performing reaction on isopropanol solution of fluorobenzaldehyde and isopropanol solution of isobutyrylacetic acid methyl ester in a first micro-reactor under catalysis of acetic acid and piperidine to generate a first product; performing reaction on the first product and isopropanol solution with free S-methyl isothiourea salt in a second micro-reactor to generate a second product; performing reaction on the second product, acetonesolution of potassium permanganate and acetic acid in a third micro-reactor to generate a third product; performing reaction on the third product and methylamine ethanol solution in a fourth micro-reactor to obtain the rosuvastatin intermediate. The rosuvastatin intermediate is low in toxicity, less in pollution, low in production cost, good in quality, high in profit, green and environmentally friendly and efficient in energy and has industry enlargement potential.

The invention provides a novel low-pressure hydrogenation technique for synthesizing isopropyl pyrazolone. Acetone and pyrazolone are condensed and hydrogenated, the acetone is taken as a solvent and Raney nickel is taken as a catalyst. The technique adopts the Raney nickel as the catalyst in the hydrogenation reaction, thereby achieving the same effect of using noble metal catalyst, lowering the cost, avoiding the pollution caused by the zinc powder process production and having the characteristics of cleanness and environment protection. The acetone is taken as the solvent of the hydrogenation reaction and serves as both the reactant and the solvent, thereby greatly increasing the concentration of the reactant and making the hydrogenation reaction easier; and the reaction pressure is low, the reaction speed is fast, the time is short and the product quality is good. Meanwhile, the solvent can be reclaimed and used intervalically, thereby having obvious cost advantage and the characteristics of low cost and environment protection. The pressure of the hydrogenation reaction is reduced, thereby increasing the safety coefficient of the reaction and reducing the requirement on a device.

The invention belongs to the technical field of chemical production, and particularly relates to a preparation method of dichloramine T or dichloramine B. The preparation method comprises the following steps: (1) substitution reaction: mixing p-toluene sulfonamide or benzenesulfonamide with a sodium hydroxide solution, heating and dissolving, introducing chlorine, and carrying out substitution reaction; (2) dissolving and extracting: adding dichloromethane for dissolving and extracting, and standing for layering to form a salt water layer and a feed liquid layer; and (3) refining: cooling and crystallizing a feed liquid layer, centrifuging and drying. The method is wide in raw material source, low in price and short in process reaction time, after the reaction, sodium chloride brine is extracted and separated from the materials through the solvent, then recrystallization is conducted in the solvent, the materials and impurities can be thoroughly separated, the product content is high, the available chlorine content can reach 58% or above, the yield can reach 97% or above, and through the recrystallization process, the product purity is high. And the crystallized product is not easy to decompose, long in preservation time and stable in quality.