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SERS (surface enhanced Raman scattering) test strip, and preparation method and application thereof

A technology of test strips and substrates, applied in the field of SERS test strips supported by gold-graphene composite nanomaterials and its preparation, can solve the problems of difficult quantitative analysis, poor anti-interference ability and stability, and few types of SERS test strips , to achieve the effect of large application potential, improved reproducibility and accuracy, and short detection time

Active Publication Date: 2018-09-14
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The problem solved by the present invention is that there are few types of SERS test strips currently used in POC detection, and the quantitative analysis is difficult, and the anti-interference ability and stability are poor

Method used

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  • SERS (surface enhanced Raman scattering) test strip, and preparation method and application thereof
  • SERS (surface enhanced Raman scattering) test strip, and preparation method and application thereof
  • SERS (surface enhanced Raman scattering) test strip, and preparation method and application thereof

Examples

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Embodiment 1

[0037] The preparation method of electropositive gold-graphene composite nanomaterial sol comprises the steps:

[0038] (1) HAuCl 4 Add methanol and sonicate for 2h to obtain solution A, HAuCl 4 The mass volume ratio with methanol is 0.15:75, the mass unit is g, and the volume unit is mL; SiO 2 Add another portion of methanol and sonicate for 2 h to obtain solution B, SiO 2 The mass volume ratio of methanol is 1:75, the mass unit is g, and the volume unit is mL; after mixing solution A and solution B, perform ultrasonic treatment for 0.5 to remove methanol, and dry the obtained mixture at 65 °C; Among them, the HAuCl 4 and SiO 2 The mass ratio is 0.35:1.

[0039] (2) Grind the mixture obtained in step (1) into powder, and then in CH 4 Flow rate is 180 cm 2 Burning 8 min under the airflow condition of / mL, burning temperature is 800 ℃, after cooling, mix with the mixed solution that HF, ethanol and water form, centrifuge, obtain gold-graphene composite nanoparticle after...

Embodiment 2

[0043] The preparation method of the SERS test strip loaded by gold graphene composite nanomaterial comprises the steps:

[0044] (1) HAuCl 4 Add methanol and sonicate for 2h to obtain solution A, HAuCl 4 The mass volume ratio with methanol is 0.25:85, the mass unit is g, and the volume unit is mL; SiO 2 Add another portion of methanol and sonicate for 1 h to obtain solution B, SiO 2 The mass-to-volume ratio of methanol is 1:85, the mass unit is g, and the volume unit is mL; after mixing solution A and solution B, perform ultrasonic treatment for 1 hour to remove methanol, and dry the obtained mixture at 75 °C; Among them, the HAuCl 4 and SiO 2 The mass ratio is 0.25:1.

[0045] (2) Grind the mixture obtained in step (1) into powder, and then in CH 4 Flow rate is 150 cm 2 Ignite 11 min under the airflow condition of / mL, and the burning temperature is 1000 ℃, mixes with the mixed solution that HF, ethanol and water are formed after cooling, centrifuges, obtains gold-gra...

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Abstract

The invention discloses an SERS (surface enhanced Raman scattering) test strip, and a preparation method and application thereof. The SERS test strip comprises a test strip substrate. The surface of the test strip substrate is loaded with a gold-graphene composite nanomaterial 60-70nm in size. The preparation method is friendly to environment, and efficient, simple and easy to operate; the prepared CS@GIANs SERS test trip has good anti-interference performance in unmarked detection of disease marker free bilirubin in serum, detection results are acquired accurately and quickly, and the test strip has a good application prospect in the field of biological and medical detection of POC and the like.

Description

technical field [0001] The invention relates to a SERS test strip and its preparation method and application, in particular to a SERS test strip loaded with gold-graphene composite nanomaterials and its preparation method and application. Background technique [0002] With the improvement of people's living standards, people pay more and more attention to their own health. Through the analysis and detection of human body fluids, the unique physiological state of the individual can be obtained, which provides a powerful judgment basis for human health and disease diagnosis. In order to improve the level of human health monitoring and realize more personalized medical treatment, more and more investment and application of point-of-care (POC) technology and equipment are being used. SERS technology has been applied in the POC field because of its rich fingerprint information and high sensitivity. [0003] The SERS technology based on fiber filter paper has attracted the attent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 陈卓邹玉秀谭蔚泓黄澌祺
Owner HUNAN UNIV