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Metoprolol tartrate tablet and preparation method thereof

A technology for metoprolol tartrate and toprolol tablets, which can be used in pharmaceutical formulations, medical preparations of non-active ingredients, and pill delivery, and can solve problems such as stickiness and unsatisfactory dissolution

Inactive Publication Date: 2018-09-21
GRAND PHARM (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The first purpose of the present invention is to provide a kind of brand-new metoprolol tartrate tablet, to overcome its easily occurring sticky punch and unsatisfactory defects of stripping

Method used

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  • Metoprolol tartrate tablet and preparation method thereof

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Effect test

Embodiment 1

[0030] The present embodiment provides a kind of metoprolol tartrate tablet, with 10000 tablets, the prescription is as follows: metoprolol tartrate 0.5KG, lactose 0.3KG, microcrystalline cellulose 0.6KG, povidone K300.03KG, carboxymethyl Sodium Starch 0.1KG, Colloidal Silicon Dioxide 0.01KG, Magnesium Stearate 0.02KG.

Embodiment 2

[0032] The present embodiment provides a kind of metoprolol tartrate tablet, with 10000 tablets, the prescription is as follows: metoprolol tartrate 0.45KG, lactose 0.4KG, microcrystalline cellulose 0.5KG, povidone K30 0.02KG, carboxymethyl Sodium Starch 0.12KG, Colloidal Silicon Dioxide 0.008KG, Magnesium Stearate 0.024KG.

Embodiment 3

[0034] The present embodiment provides a kind of metoprolol tartrate tablet, with 10000 tablets, the prescription is as follows: metoprolol tartrate 0.56KG, lactose 0.2KG, microcrystalline cellulose 0.7KG, povidone K30 0.04KG, carboxymethyl Sodium Starch 0.06KG, Colloidal Silicon Dioxide 0.012KG, Magnesium Stearate 0.016KG.

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Abstract

The invention relates to the field of pharmaceutic preparations, in particular to a metoprolol tartrate tablet and a preparation method thereof. The provided metoprolol tartrate tablet is prepared from, by weight, 0.45-0.56 part of metoprolol tartrate, 0.2-0.4 part of lactose, 0.5-0.7 part of microcrystalline cellulose, 0.02-0.04 part of povidone K30, 0.06-0.12 part of sodium carboxymethyl starch,0.008-0.012 part of colloidal silicon dioxide and 0.016-0.024 part of magnesium stearate. The formula of an existing metoprolol tartrate tablet is optimized, and it is accidentally found that under the condition of not needing to add resin, surprisingly technical effects on overcoming sticky dissolution and dissolution rate are achieved.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a metoprolol tartrate tablet and a preparation method thereof. Background technique [0002] Metoprolol tartrate is widely used clinically to treat hypertension, angina pectoris, myocardial infarction, hypertrophic cardiomyopathy, aortic dissection, arrhythmia, hyperthyroidism, cardiac neurosis, etc., and it is still used in the treatment of heart failure in recent years. treat. [0003] The solubility of metoprolol tartrate in water is very large, and the actual measurement can reach 1.5g / mL. However, most of the traditional wet granulation uses starch, dextrin or starch dextrin as the binder, which is dissolved in purified water and punched. Metoprolol granules are easily soluble and sticky, and the resulting granules have poor fluidity and are easily oxidized by moisture, which brings difficulties to granulation. Chinese application CN102716091A discloses a technical scheme for...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/26A61K47/38A61K47/32A61K47/36A61K47/04A61K31/138A61P9/12A61P9/10A61P9/00A61P9/06A61P5/16A61P25/00A61P9/04
Inventor 王芝吴鸣蔡一聪彭莉王凡
Owner GRAND PHARM (CHINA) CO LTD
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