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Composition for improving sleep and preparation thereof

A technology of composition and traditional Chinese medicine preparation, which is applied in the field of sleep-improving composition and its preparation, to achieve the effect of regulating wakefulness cycle and improving sleep quality

Inactive Publication Date: 2018-09-25
CHIATAI QINGCHUNBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no related medicine so far, especially traditional Chinese medicine preparations

Method used

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  • Composition for improving sleep and preparation thereof
  • Composition for improving sleep and preparation thereof
  • Composition for improving sleep and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Recipe: Rehmannia glutinosa 165g, Poria cocos 33g

[0021] Take the prescribed amount of medicinal materials, add 10 times the amount of water to decoct 3 times, decoct for 2 hours for the first time, decoct for 1 hour for the second and third times respectively, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.35~ 1.40 (80°C) about 50g of extract, add 80g of refined honey, mix well and boil to make a paste.

Embodiment 2

[0023] Recipe: Rehmannia glutinosa 409g, Poria cocos 77g

[0024] Take the rehmannia glutinosa and Poria cocos in the formula, add 10 times the mass of water and decoct 3 times, decoct for 2 hours for the first time, decoct for 1 hour for the second and third times respectively, combine the decoctions, filter, and concentrate the filtrate to relative density 1.25 ~ 1.30 to obtain extract (60 ℃), about 140g extract, add 100g dextrin to granulate and dry to make granules.

Embodiment 3

[0026] Recipe: Rehmannia glutinosa 150g, red ginseng 60g, Poria cocos 33g, Ophiopogon japonicus 9g, Asparagus 9g, Digupi 9g.

[0027] Take raw rehmannia glutinosa, Radix Ophiopogon japonicus, Radix Asparagus, Digupi, and Poria cocos according to the formula, add 8 times the mass of water to decoct 3 times, decoct for 2 hours for the first time, decoct for 1 hour for the second and third times, and decoct together liquid, filtered, and the filtrate was concentrated to a relative density of 1.30-1.40 (60°C) to obtain an extract. Red ginseng is crushed into fine powder, mixed with extract and appropriate amount of starch, dried and granulated, pressed into tablets and coated to make tablets. It can also be filled into capsules after granulation to make capsules.

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Abstract

The invention discloses a traditional Chinese medicine composition for improving sleep and a preparation thereof. The traditional Chinese medicine composition is at least prepared from the following raw materials in parts by weight: 14-18 parts of radix rehmanniae and 2-4 parts of poria cocos. After pharmaceutically acceptable auxiliary materials are added into the traditional Chinese medicine composition, one of the following pharmaceutical preparations can be prepared: tablets, granules, capsules, oral liquid or plaster for internal use. The composition or the preparations containing the composition have the effects of changing a circadian rhythms period, prolonging the deep sleep time and improving the intracerebral dopamine content, are capable of regulating a sleeping-awakening period, and improving the sleep quality of middle aged and elderly people.

Description

1. Technical field [0001] The invention relates to a composition and a preparation thereof capable of regulating circadian rhythms of middle-aged and elderly people and improving sleep quality. 2. Background technology [0002] Circadian rhythm is the most common phenomenon in nature, which refers to the fluctuation of life activities in a cycle of about 24 hours. Circadian rhythms are controlled by internal biological clocks and are endogenous and self-sustaining. Mammalian circadian clocks can be divided into two categories: central and peripheral. The central circadian clock is located in the suprachiasmatic nucleus neurons (SCN) of the hypothalamus and regulates the behavior and circadian rhythms of the body, including sleep, body temperature, endocrine, blood pressure and exercise etc. Peripheral circadian clock exists in most tissues except SCN, including liver, heart, kidney, etc., and regulates the circadian rhythm of peripheral tissues. Usually, the operation of ...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K36/8968A61P25/20
CPCA61K36/076A61K36/258A61K36/804A61K36/815A61K36/8965A61K36/8968A61K2236/331A61K2236/39A61P25/20A61K2300/00
Inventor 钱景瞿海斌刘雳程翼宇顾佳丽
Owner CHIATAI QINGCHUNBAO PHARMA
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