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New uses of traditional Chinese medicine composition

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine, can solve the problems of high risk, high morbidity and high fatality rate threatening physical health, high cost and the like

Inactive Publication Date: 2018-09-25
CHENGDU DIAO GROUP TIANFU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the cancer treatments are surgical treatment combined with radiotherapy and chemotherapy. However, this method has great trauma to the patient, high risk, and high cost, but the curative effect is not ideal.
[0003] The high morbidity and mortality of lung cancer have seriously threatened people's health. The wide application of multidisciplinary comprehensive treatment has reached a plateau, but the 5-year survival rate is still less than 20%.

Method used

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  • New uses of traditional Chinese medicine composition
  • New uses of traditional Chinese medicine composition
  • New uses of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 Chinese medicine composition

[0025] API:

[0026]

[0027] Preparation:

[0028] The above thirty-four medicinal herbs, turtle shells, decoct 3 times (add 9 times the water), 3 hours each time, combine the decoction, filter, and concentrate the filtrate to an appropriate amount (about 180ml); angelica, chuanxiong, turmeric, galangal , cinnamon, clove, asafoetida, and balsamic extract by steam distillation for 6 hours (add 12 times of water), collect volatile oil and distillate (about 50ml), decoct the dregs and other twenty-five flavors with water three times, the first time 2 hours (add 12 times of water), 1.5 hours for the second and third times (add 10 times and 8 times of water respectively), combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.15 (50-60°C), add ethanol Make the alcohol content reach 70%, adjust the pH value to 7.5-8.0, let it stand (0-5°C) for 24 hours, filter, ...

Embodiment 2

[0029] Embodiment 2 drug effect test

[0030] 1. Materials and Methods

[0031] 1.1 Materials

[0032] 1.1.2 Animals

[0033] 8-week-old SPF-grade male C57BL / 6J mice, grade 2, weighing 20±2g, provided by West China Medical Experimental Animal Center of Sichuan University, certificate number SCXK (Sichuan) 2013-026, bred in IVC, Department of Pharmacology, West China School of Pharmacy, Sichuan University Animal room, certificate number: SYXK (Sichuan) 2013-113, Chengdu Dashuo Biotechnology Co., Ltd. provides SPF grade mouse feed. Before the experiment, the animals were adaptively fed for 1 week. The feeding environment was 20-25° C. and 70% humidity. During the whole experiment, the animals were free to eat and drink.

[0034] 1.1.2 Cell lines

[0035] Mouse Lewis lung cancer strain (Lewis lung carcinoma, LLC): Provided by the State Key Laboratory of Biotherapy, Sichuan University.

[0036] Human lung cancer cell line A549: provided by the State Key Laboratory of Biothera...

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Abstract

The invention provides applications of a traditional Chinese medicine composition in preparation of cancer treating drugs, wherein the bulk drugs of the traditional Chinese medicine composition comprise 34 bulk drugs such as Leonurus artemisia, safflower, Zanthoxylum bungeanum Maxim and the like. According to the present invention, the research results show that the traditional Chinese medicine composition can protect the immune organs of cancer patients, improve blood hypercoagulability, reduce inflammation reaction and inhibit the migration of tumor cells so as to provide antitumor effect.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to a new application of a traditional Chinese medicine composition in treating lung cancer, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Cancer is a major disease that threatens human health, and its fatality rate is increasing year by year. Its occurrence and development are complex pathological processes involving multiple factors, multiple gene changes, and multi-stage development. At present, the treatment of cancer mostly adopts surgical treatment combined with radiotherapy and chemotherapy, but this method has great trauma to the patient, high risk, and high cost, but the curative effect is not ideal. [0003] The high morbidity and mortality of lung cancer have seriously threatened people's health. The wide application of multidisciplinary comprehensive treatment has reached a plateau in its...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P35/00A61P35/04A61P37/02A61P7/02A61P29/00A61K35/62
CPCA61K36/8905A61K36/902A61K36/9062A61K36/9066A61K35/24A61K35/586A61K35/62A61K35/63A61K36/22A61K36/23A61K36/232A61K36/235A61K36/236A61K36/258A61K36/282A61K36/286A61K36/324A61K36/328A61K36/48A61K36/533A61K36/535A61K36/54A61K36/61A61K36/65A61K36/66A61K36/708A61K36/71A61K36/736A61K36/754A61K36/758A61K36/804A61K36/88A61K2236/39A61K2236/53A61K2236/51A61K2236/333A61K2236/331A61K2300/00
Inventor 姚华王军杜军李芳
Owner CHENGDU DIAO GROUP TIANFU PHARMA
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