Repairing stock solution as well as preparation method and application thereof

A raw material and buffer technology, applied in the field of skin care products, can solve the problems of high price, limited popularization and application, and poor storage of skin care products, and achieve the effects of relieving dry skin, enhancing curative effect, and reducing prices

Pending Publication Date: 2018-09-28
广州领衔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, due to these shortcomings of bFGF in the application field, the price of bFGF-containing skin care products is relatively high. Generally, it is stored in a solid state after freeze-drying, and it needs to be reconstituted when used, which seriously limits its popularization and application.
[0006] Therefore, research and development of a bFGF-cont

Method used

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  • Repairing stock solution as well as preparation method and application thereof
  • Repairing stock solution as well as preparation method and application thereof
  • Repairing stock solution as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Example Embodiment

[0053] According to one aspect of the present invention, a preparation method of a repairing stock solution, the method comprises the following steps:

[0054] First, the precursor solution is prepared by step-by-step cooling and feeding. When the sol is cooled to 29-32° C. in steps, basic fibroblast growth factor bFGF is added and mixed thoroughly to obtain a repairing stock solution.

[0055] The preparation method of the repairing stock solution provided by the present invention is as follows: firstly, the precursor solution is prepared by the method of step-by-step cooling and feeding, and when the sol is cooled to 29-32° C. in steps, the basic fibroblast growth factor bFGF is added and fully mixed to obtain Repair lotion. The above method adds the basic fibroblast growth factor bFGF to the sol at 29-32 °C, which can effectively avoid the protein denaturation problem of bFGF caused by high temperature. At the same time, adding bFGF at a certain temperature can make bFGF mo...

Example Embodiment

[0065] Example 1

[0066] A repairing stock solution, the repairing stock solution includes basic fibroblast growth factor bFGF and a precursor solution;

[0067] The precursor solution is mainly made of the following raw materials in parts by weight:

[0068]

[0069] The weight ratio of the basic fibroblast growth factor bFGF to the precursor solution is 1:1000000.

Example Embodiment

[0070] Example 2

[0071] A repairing stock solution, the repairing stock solution includes basic fibroblast growth factor bFGF and a precursor solution;

[0072] The precursor solution is mainly made of the following raw materials in parts by weight:

[0073]

[0074] The weight ratio of the basic fibroblast growth factor bFGF to the precursor solution is 2:1,000,000.

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Abstract

The invention provides a repairing stock solution as well as a preparation method and application thereof, and relates to the technical field of skin care products. The repairing stock solution is prepared from a basic fibroblast growth factor bFGF and a precursor solution, wherein a weight ratio of the basic fibroblast growth factor bFGF to the precursor solution is (1 to 2) to 1000000. The bFGFcan keep better stability in the precursor solution of the repairing stock solution disclosed by the invention; through detection, the bFGF still has better activity after being stored for half a yearin a normal temperature state, so that the problem that a skin care product containing the bFGF component is difficultly stored at a normal temperature is effectively alleviated; meanwhile, due to cooperative application of various components in the precursor solution and the bFGF, the various components can develop the original effect, and also can play a synergistic effect, so that a curative effect of the repairing stock solution is further enhanced; moreover, alleviation of symptoms such as dryness of skin, aging, dark yellow, color spots, pimples and allergy treated by using the repairing stock solution is obviously superior to alleviation of the symptoms treated by using existing skin care products.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to a repairing stock solution and its preparation method and application. Background technique [0002] As early as 1940, Hoftman found a substance that could promote the growth of fibroblasts in the extracts of the brain and pituitary gland. In 1974, the substance was isolated and purified, and named as fibroblast growth factor (fibroblast growthfactor, FGF). Then people isolated a highly homologous substance, because it contains more acidic amino acid bases, and its isoelectric point is acidic (5.6), so it was named acidic FGF (aFGF). Acid and heat sensitive, the isoelectric point is alkaline (9.6), it is called basic FGF (bFGF). [0003] Basic fibroblast growth factor bFGF is a mitogenic cationic polypeptide containing 155 amino acids, with a molecular weight of 16-18.5KD. Success in purification by heparin-agarose affinity chromatography followed the high degree of...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/60A61K8/86A61K8/37A61K8/42A61K8/35A61K8/9728A61Q19/00A61Q19/08A61Q19/02A61P17/10A61P37/08
CPCA61K8/35A61K8/375A61K8/42A61K8/602A61K8/64A61K8/86A61K8/9728A61K2800/592A61P17/10A61P37/08A61Q19/00A61Q19/004A61Q19/005A61Q19/007A61Q19/02A61Q19/08
Inventor 王宏刘斌王华英
Owner 广州领衔生物科技有限公司
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