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Application of a zeolite imidazole framework material in magnetic resonance imaging

A zeolite imidazole framework and magnetic resonance imaging technology, which is applied in the field of magnetic resonance imaging and achieves the effects of high sensitivity, easy synthesis and low price

Active Publication Date: 2021-10-08
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no literature has reported the use of zeolitic imidazole framework materials as 129 Xe host molecules to construct hyperpolarized zeolitic imidazole frameworks 129 Xe magnetic resonance contrast agent

Method used

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  • Application of a zeolite imidazole framework material in magnetic resonance imaging
  • Application of a zeolite imidazole framework material in magnetic resonance imaging
  • Application of a zeolite imidazole framework material in magnetic resonance imaging

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Experimental program
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Effect test

preparation example Construction

[0019] The preparation method of the zeolite imidazole framework material ZIF-8 was synthesized by referring to the literature (Chem. Commun., 2011, 47, 2071-2073).

[0020] NMR instrument (400MHz Bruker AV400wide bore spectrometer).

Embodiment 1

[0022] Hyper-CEST spectrum test experiment of zeolite imidazole framework material ZIF-8 at 298K

[0023] 1. Experimental method:

[0024] The specific experimental steps are as follows:

[0025] 1.1. Select the zeolite imidazole framework material ZIF-8 with a particle size of about 80nm;

[0026] 1.2. Weigh 9.75 mg of zeolite imidazole framework material ZIF-8, add 1 mL of ultrapure water, and sonicate at room temperature (25°C) for 30 minutes to fully disperse zeolite imidazole framework material ZIF-8 to obtain a dispersion;

[0027] 1.3. Take 20uL of the dispersion, dilute it to 2mL with ultrapure water, mix it and transfer it to a 10mm NMR sample tube for testing;

[0028] 1.4. During the test, Xe gas (10% N 2 , 88% He, 2% Xe) passed through the NMR sample tube after flowing through the hyperpolarization instrument, after aeration for 20s, the aeration was stopped, and then partial hyperpolarization was saturated by selective pulse 129 Excited with 90° pulse after Xe...

Embodiment 2

[0032] Effect of temperature on the Hyper-CEST effect of zeolite imidazole framework material ZIF-8

[0033] 1. Experimental method:

[0034] The specific experimental steps are as follows:

[0035] 1.1. Select the zeolite imidazole framework material ZIF-8 with a particle size of about 80nm;

[0036] 1.2. Weigh 9.75 mg of zeolite imidazole framework material ZIF-8, add 1 mL of ultrapure water, and sonicate at room temperature (25°C) for 30 minutes to fully disperse zeolite imidazole framework material ZIF-8 to obtain a dispersion;

[0037] 1.3. Take 20uL of the dispersion, dilute it to 2mL with ultrapure water, mix it and transfer it to a 10mm NMR sample tube for testing;

[0038] 1.4. During the test, Xe gas (10% N 2 , 88% He, 2% Xe) passed through the NMR sample tube after flowing through the hyperpolarization instrument, after aeration for 20s, the aeration was stopped, and then partial hyperpolarization was saturated by selective pulse 129 After the Xe signal, use a 9...

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Abstract

The invention discloses the application of a zeolite imidazole framework material in magnetic resonance imaging. The invention creatively uses the zeolite imidazole framework material as a hyperpolarized 129 The host supramolecular cage (carrier) of Xe obtained a temperature-sensitive hyperpolarization based on zeolitic imidazole framework nanoparticles 129 Xe magnetic resonance contrast agent has the prospect of being suitable for temperature detection of biological microenvironment.

Description

technical field [0001] The invention belongs to the technical field of magnetic resonance imaging, and in particular relates to the application of a zeolite imidazole framework material in magnetic resonance imaging. Background technique [0002] Magnetic resonance imaging has become an important tool for clinical disease diagnosis due to its absence of ionizing radiation, non-injury, high tissue penetration and spatial resolution. The traditional magnetic resonance imaging signal comes from the protons of water or fat in the body, and there is strong background signal interference. In medical diagnosis, in order to improve the tissue contrast between the lesion site and the normal site, clinically usually use paramagnetic metals (such as Gd 3+ , Mn 2+ ) compounds as contrast agents. Surveys have shown that 40% to 50% of current MRI experiments use contrast agents (J. Magn. Reson. Imaging., 1999, 10, 477-484). Although this type of contrast agent based on paramagnetic me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/10
CPCA61K49/10
Inventor 周欣曾庆斌郭茜旎孙献平刘买利
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI