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Submicron fiber containing medicine-carrying nanometer balls and preparation method thereof

A drug-loaded nano- and sub-micron technology, which can be applied to non-active ingredients in medical preparations, pharmaceutical formulations, and chemical characteristics of fibers, etc. It can achieve the effect of good slow release effect, novel structure and low cost

Inactive Publication Date: 2018-09-28
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this structure, the interaction between the drug and the matrix is ​​not strong, often accompanied by the phenomenon of sudden release of the drug, and the rate of drug release decreases with time

Method used

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  • Submicron fiber containing medicine-carrying nanometer balls and preparation method thereof
  • Submicron fiber containing medicine-carrying nanometer balls and preparation method thereof
  • Submicron fiber containing medicine-carrying nanometer balls and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Hollow mesoporous SiO 2 Preparation: Add 4.3ml ammonia water to 0.15g polyacrylic acid aqueous solution, stir well, add 87ml absolute ethanol, stir at room temperature for 1h, add 1.4ml ethyl orthosilicate dropwise, continue to seal and stir at room temperature for 12h. The resulting solution was centrifuged and cleaned 5 times, placed in an oven at 50°C and dried to obtain hollow mesoporous silica, which was dispersed in an ethanol solution and placed on a silicon wafer and a carbon film for field emission and transmission. The test results are as follows figure 1 with figure 2 As shown, it can be seen that the shape of the nanoparticles is relatively regular, the size is not uniform, and there is an obvious hollow mesoporous structure.

[0032] (2) SiO loaded with triclosan 2 Preparation of nanoparticles: Disperse 1.6 g of triclosan in 60 ml of absolute ethanol, and stir at room temperature for 1 hour to completely dissolve triclosan. Weigh 0.8g of hollow mesoporou...

Embodiment 2

[0038] (1) Hollow mesoporous SiO 2 Preparation: Add 4.5ml of ammonia to 0.17g of polyacrylic acid aqueous solution. After stirring, add 88ml of absolute ethanol. After stirring for 1h at room temperature, add 1.7ml of ethyl orthosilicate dropwise and continue to seal and stir at room temperature for 12h. The resulting solution was centrifuged and cleaned 5 times, placed in an oven at 50°C and dried to obtain hollow mesoporous silica, which was dispersed in an ethanol solution and placed on a silicon wafer and a carbon film for field emission and transmission. The test results are as follows figure 1 with figure 2 As shown, it can be seen that the shape of the nanoparticles is relatively regular, the size is not uniform, and there is an obvious hollow mesoporous structure.

[0039] (2) SiO loaded with triclosan 2 Preparation of nanoparticles: Disperse 1.6 g of triclosan in 60 ml of absolute ethanol, and stir at room temperature for 1 hour to completely dissolve triclosan. Weigh ...

Embodiment 3

[0045] (1) Hollow mesoporous SiO 2 Preparation: Add 4.5ml of ammonia to 0.18g of polyacrylic acid aqueous solution. After stirring, add 90ml of absolute ethanol. After stirring for 1h at room temperature, add 1.5ml of ethyl orthosilicate dropwise, and continue to seal and stir at room temperature for 12h. The resulting solution was centrifuged and cleaned 5 times, placed in an oven at 50°C and dried to obtain hollow mesoporous silica, which was dispersed in an ethanol solution and placed on a silicon wafer and a carbon film for field emission and transmission. The test results are as follows figure 1 with figure 2 As shown, it can be seen that the shape of the nanoparticles is relatively regular, the size is not uniform, and there is an obvious hollow mesoporous structure.

[0046] (2) SiO loaded with triclosan 2 Preparation of nanoparticles: Disperse 1.6 g of triclosan in 60 ml of absolute ethanol, and stir at room temperature for 1 hour to completely dissolve triclosan. Weigh...

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Abstract

The invention relates to a submicron fiber containing medicine-carrying nanometer balls and a preparation method thereof. The material is the submicron fiber containing triclosan-carrying SiO2 / CS / PAAnanometer particles. The preparation method comprises the steps of preparing hollow mesoporous SiO2, preparing triclosan-carrying SiO2 nanometer particles, preparing triclosan-carrying SiO2 / CS nanometer particles, preparing triclosan-carrying SiO2 / CS / PAA nanometer particles and performing static spinning on the SiO-containing medicine-carrying nanometer ball fiber. The process provided by the invention has the advantages that the preparation route is simple; the reaction conditions are mild; the cost is low; nontoxicity is realized.

Description

Technical field [0001] The invention belongs to the field of submicron fiber materials and preparation thereof, and particularly relates to a submicron fiber containing drug-loaded nanospheres and a preparation method thereof. Background technique [0002] In the nano drug-carrying system, drug molecules are usually uniformly dispersed in the carrier matrix or adsorbed on the surface of the carrier, and the obtained carrier-drug complex can not only carry the drug, but also influence and control the release kinetics of the drug. Common nano drug carriers include nano microspheres, nano fibers, nano capsules, nano liposomes and so on. Nano-medicine carrier has a higher specific surface area and can load a higher amount of drug; and nano-medicine carriers with different environmental stimuli responsiveness can be prepared to make them have biodegradability, temperature sensitivity, pH sensitivity and other characteristics to control Drug release; it can also improve the effective ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/54D01F1/10A61K9/00A61K47/04A61K9/51A61K47/02A61K47/32A61K47/36A61K47/69A61P31/04
CPCA61K9/0092A61K9/5138A61K9/5161A61K47/02A61K47/32A61K47/6949A61P31/04D01F1/10D01F1/103D01F6/54
Inventor 覃小红仇巧华俞建勇
Owner DONGHUA UNIV
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