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Germicidal composition

A composition and bactericidal technology, which is applied in the field of bactericidal compositions, can solve the problems of low drug susceptibility, effect persistence, etc.

Pending Publication Date: 2018-09-28
GOWAN CROP PROTECTION LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Although a variety of agricultural and horticultural fungicides have been discovered so far, there are still many problems related to the problem of low chemical sensitivity, the problem of continuous effect, safety during use (for example, safety for operators), or safety in terms of environmental impact. Look, there is still a need for new drugs with high efficacy and high safety

Method used

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  • Germicidal composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0449] Example 1: 4-[4-(6,9-difluoro-1,5-dihydro-3H-2,4-benzodioxa -3-yl)-2-thiazolyl]-1-[2-[5-methyl-3-(trifluoromethyl)- 1 Preparation of H-pyrazol-1-yl]acetyl]piperidine (compound 1-3)

[0450] 4-(4-formyl-2-thiazolyl)-1-[2-[5-methyl-3-(trifluoromethyl)- 1 H-pyrazol-1-yl]acetyl]piperidine (210 mg) (compound described in WO2008 / 013622 publication), 3,6-difluoro-1,2-benzenedimethanol (210 mg) and p-toluenesulfon Acid monohydrate (11 mg) was dissolved in toluene (15 mL) and heated to reflux for 1 hour using a Dean-Stark apparatus. After cooling the reaction solution to room temperature, it was diluted with ethyl acetate, and washed with water and saturated brine. The organic layer was dried over anhydrous sodium sulfate, and after the inorganic matter was filtered off, the solvent was distilled off under reduced pressure. The residue was purified using a fast (flash) automatic refining device (Biotage AB / Isolera TM ) silica gel flash chromatography (ethyl acetate-hexane:...

Embodiment 2

[0451] Example 2: 4-[4-(6-methylsulfonyloxy-1,5-dihydro-3H-2,4-benzodioxa -3-yl)-2-thiazolyl]-1-[2-[5-methyl-3-(trifluoromethyl)- 1 Preparation of H-pyrazol-1-yl]acetyl]piperidine (compound 1-6)

[0452] 4-(4-formyl-2-thiazolyl)-l-[2-[5-methyl-3-(trifluoromethyl)- 1 H-pyrazol-1-yl]acetyl]piperidine (200mg), 3-methylsulfonyloxy-1,2-benzenedimethanol (121mg) and p-toluenesulfonic acid monohydrate (20mg) were dissolved in Toluene (20 mL) was subjected to the same reaction as in the preparation of compound 1-3 and purified to obtain the title compound as a white amorphous solid (298 mg, yield 96%).

Embodiment 3

[0453] Example 3: 4-[4-(6-fluoro-9-methylsulfonyloxy-1,5-dihydro-3H-2,4-benzodioxa -3-yl)-2-thiazolyl]-1-[2-[5-methyl-3-(trifluoromethyl)- 1 Preparation of H-pyrazol-1-yl]acetyl]piperidine (compound 1-8)

[0454] 4-(4-formyl-2-thiazolyl)-1-[2-[5-methyl-3-(trifluoromethyl)- 1 H-pyrazol-1-yl]acetyl]piperidine (220 mg), 3-fluoro-6-methylsulfonyloxy-1,2-benzenedimethanol (150 mg) and p-toluenesulfonic acid monohydrate ( 20 mg) was dissolved in toluene (15 mL), subjected to the same reaction as in the preparation of compound 1-3, and purified to obtain the title compound as a white amorphous solid (297 mg, yield 84%). Methanol was added to the obtained resin, dissolved under reflux under heating, and then left to stand at room temperature to obtain a white solid (melting point: 151° C.).

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Abstract

A method for controlling plant diseases caused by phytopathogenic microorganisms. The method includes a step for applying a germicidal composition which contains a compound represented by formula [1]or a salt thereof.

Description

【Technical field】 [0001] The present invention relates to a fungicidal composition, characterized in that it contains at least one of a fused 11-membered ring compound, an enantiomer thereof, a mixture thereof, or an agriculturally and horticulturally acceptable salt thereof, and other agriculturally and horticulturally acceptable salts. At least one kind of fungicide or salt thereof. 【Background technique】 [0002] Although a variety of agricultural and horticultural fungicides have been discovered so far, they are still limited in terms of issues such as low susceptibility to the chemicals, sustainability of effects, safety during use (for example, safety for workers), or safety in terms of environmental impact. Look, there is still a need for new pharmaceuticals with high efficacy and safety. In addition, control methods are needed to prevent plant pathogenic bacteria from acquiring tolerance and low susceptibility to chemicals. [0003] [Existing technical documents] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/78A01N43/54A01N43/56A01N43/653A01N37/18A01N43/76A01N43/84A01N43/90A01N47/04A01N47/12A01N47/34A01N47/38A01N37/34A01N37/46A01N37/50A01N43/36A01N43/40A01N43/42A01N43/50A01N47/44A01N55/02A01N57/10A01N63/00A01P3/00
CPCA01N43/56A01N47/12A01N37/20A01N43/76A01N43/50A01N43/40A01N43/90A01N37/36A01N37/46A01N43/78A01N37/38A01N47/34A01N59/20A01N37/34A01N47/14A01N47/04A01N37/50A01N43/54A01N43/42A01N57/12A01N47/44A01N43/36A01N47/38A01N43/653A01G7/06A01N25/04A01N25/08
Inventor 坂口贵俊冈田直己
Owner GOWAN CROP PROTECTION LTD