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Medicinal composition of cultured sihippocampus peptide and preparation method thereof

A technology of hippocampus and pharmaceutical excipients, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems that are not suitable for injection application and trouble the application of Peihuaxihippocampus peptide

Active Publication Date: 2021-10-26
JIANGSU HANSOH PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Peihua Xihippocampus peptide is easy to degrade under light, high humidity and oxidation conditions, and is easy to degrade under peracid and overalkali conditions. The above problems plague the application of Peihua Xihippocampus peptide in pharmacy
Patent CN 201210245744.0 discloses the preparation of Peihua Xihippocampus peptide injection with poloxamer 188, L-arginine, mannitol, potassium dihydrogen phosphate, etc. as auxiliary materials, but the preparation contains multiple components and is not suitable for injection applications. Therefore this area is badly in need of a kind of prescription simple and good stability cultured western hippocampal peptide injection preparation

Method used

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  • Medicinal composition of cultured sihippocampus peptide and preparation method thereof
  • Medicinal composition of cultured sihippocampus peptide and preparation method thereof
  • Medicinal composition of cultured sihippocampus peptide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]

[0040] Weigh 15g of lactose, dissolve it in sterile water for injection, remove the pyrogen by ultrafiltration, add 4g of raw material medicine according to the formula, dissolve and mix well, adjust the pH value to 4.0 with acetic acid and sodium acetate, and dilute to 1000ml .Filtered by 0.22 micron PVDF, divided into glass bottles with 4 mg of raw material per bottle, and freeze-dried under sterile conditions.

[0041] Freeze-drying is pre-frozen at -36°C for 5 hours, and then freeze-dried; the first drying time is 20 hours at 5°C, the second drying is at 25°C for 10 hours, and the holding stage is at 30°C for 5 hours.

Embodiment 2

[0043]

[0044] Weigh 10g of lactose, dissolve it in sterile water for injection, remove the pyrogen by ultrafiltration, add 4g of raw material medicine according to the formula, dissolve and mix well, adjust the pH value to 5.0 with acetic acid and sodium acetate, and dilute to 1000ml .Filtered by 0.22 micron PVDF, divided into glass bottles with 4 mg of raw material per bottle, and freeze-dried under sterile conditions.

[0045] Freeze-drying is pre-frozen at -40°C for 5 hours, and then freeze-dried; the first drying time is 25 hours at 5°C, the second drying is at 25°C for 10 hours, and the holding stage is at 30°C for 5 hours.

Embodiment 3

[0047]

[0048]

[0049] Weigh 15g of lactose, dissolve it in sterile water for injection, remove the pyrogen by ultrafiltration, add 4mg of raw material medicine according to the formula, dissolve and mix well, adjust the pH value to 5.0 with sodium dihydrogen phosphate and sodium hydroxide, and set The capacity is up to 1000ml. It is filtered by 0.22 micron PVDF, divided into glass bottles with 4 mg of raw material per bottle, and freeze-dried under sterile conditions.

[0050] Freeze-drying is pre-frozen at -36°C for 3 hours, and then freeze-dried; the first drying time is 20 hours at 5°C, the second drying is at 25°C for 10 hours, and the heat preservation stage is dried at 30°C for 5 hours. chemical hippocampal peptide.

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PUM

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Abstract

The invention discloses a medicinal composition of cultured western hippocampal peptide and a preparation method thereof, in particular to a pharmaceutical composition with cultured western hippocampal peptide as an active ingredient, including active ingredients and pharmaceutically acceptable pharmaceutical excipients, The auxiliary materials are selected from excipients and pH regulators, optionally including isotonic regulators. The pharmaceutical composition provided by the invention does not need to add a stabilizer, and its stability is better than that of the existing preparations.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a cultured western hippocampal peptide preparation and a preparation method thereof. Background technique [0002] The chemical structure of cultured western hippocampal peptide is: [0003] [0004] Chinese chemical name: N,N-two{2′-acetyl[ε″-amino-(acetyl-glycyl-glycyl-L-threonyl-L-tyrosyl-L-seryl- L-cysteinyl-L-histidyl-L-benzoyl-glycyl-L-alanyl-L-leucyl-L-threonyl-L-tryptophanyl-L- Valyl-L-cysteinyl-L-arginyl-L-prolyl-L-glutamyl-L-arginyl-glycyl-β-alanyl-L-lysine Acid ring 6→15 disulfide)]}-3-polyethylene glycol aminopropanamide [0005] Cuihua Xihippocampus peptide is a derivative of erythropoietin mimic peptide modified by polyethylene glycol, in which EPO acts on bone marrow hematopoietic cells, stimulates mitosis and differentiation of erythroid precursor cells, promotes proliferation and differentiation of erythroid stem cells, and finally mat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K38/18A61K47/26A61P7/06
CPCA61K9/0019A61K9/19A61K38/1816A61K47/26
Inventor 孙运栋胡迪袁恒立徐春来王革
Owner JIANGSU HANSOH PHARMA CO LTD