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Application of aspirin in preparation of drugs for treating IVDD (intervertebral disc degeneration)

A technology of aspirin and intervertebral discs, applied in the field of new drug applications, to achieve the effect of reducing expression, reducing protein expression, and improving cell morphology measurement results

Inactive Publication Date: 2018-10-02
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether Aspirin can inhibit the degeneration of the intervertebral disc has not been reported at present, and the present invention thus derives

Method used

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  • Application of aspirin in preparation of drugs for treating IVDD (intervertebral disc degeneration)
  • Application of aspirin in preparation of drugs for treating IVDD (intervertebral disc degeneration)
  • Application of aspirin in preparation of drugs for treating IVDD (intervertebral disc degeneration)

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Embodiment Construction

[0027]The present invention will be further described below in conjunction with specific examples, but the examples are only exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0028] 1. Materials and methods

[0029] 1. Materials

[0030] 1.1 Reagents and experimental equipment

[0031] 1.1.1 Main Drugs and Reagents

[0032] Aspirin (Aspirin), dimethyl sulfoxide (DMSO), LPS (E.coli 0111:B4), (2',7'-diacetyl dichlorofluorescein) DCFH-D, DAB chromogen, hematoxylin, i Red, purchased from Sigma, Shanghai, China; F12-DMEM medium, PBS, purchased from Hyclone (USA); fetal bovine serum (FBS), trypsin, penicillin-streptomycin, p...

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Abstract

The invention belongs to the technical field of new applications of drugs, and particularly relates to an application of aspirin in preparation of drugs for treating IVDD (intervertebral disc degeneration). An intervertebral disc degeneration model is constructed by applying LPS (lipopolysaccharide)-induced oxidative stress, the therapeutic effect of aspirin on IVDD is observed, and the therapeutic effect of Aspirin on IVDD is evaluated by observing oxidative stress and various indexes of IVDD. Western blot demonstrates the brief mechanism of Aspirin in reducing oxidative stress and alleviating IVDD. IVDD is caused by oxidative stress in intervertebral disc nucleus pulposus tissue, Aspirin delays IVDD by inhibiting the oxidative stress in the nucleus pulposus tissue and further reducing decomposition of cell matrix and type II collagen, so that a new approach is provided for prevention and treatment of IVDD.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and in particular relates to the application of aspirin in the preparation of medicines for treating degeneration of intervertebral discs. Background technique [0002] Intervertebral disc degeneration (IVDD) is one of the main causes of low back pain (LBP) in modern society, and it brings serious physical, psychological and economic burdens to people. The specific mechanism of NMP is still unclear. Previous studies mainly focused on biomechanics and inflammatory pathology, but recently scholars have begun to pay attention to the relationship between energy metabolism and degeneration of the nucleus pulposus. At present, the curative effect of non-surgical treatment is not clear. Most patients still need to undergo nucleus pulposus surgery in the later stage. The operation is inevitably traumatic. Therefore, how to effectively prevent and treat IVDD has become an important topic in ...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61P29/00A61P19/08
CPCA61K31/616A61P19/08A61P29/00
Inventor 耿德春毛海青刘禹郭晓斌林佳益柏家祥郁彬清沈冀宁杨惠林
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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