Drug combination targeting intracellular osmotic pressure for the treatment of cerebral edema

A cerebral edema and drug technology, applied in the field of medicine, can solve the problems of inaccurate curative effect and limited effect, and achieve the effect of treating cerebral edema and maintaining stability

Active Publication Date: 2020-01-07
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many drugs clinically used to treat cerebral edema with complex mechanisms, but most of them have limited effects and uncertain curative effects

Method used

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  • Drug combination targeting intracellular osmotic pressure for the treatment of cerebral edema
  • Drug combination targeting intracellular osmotic pressure for the treatment of cerebral edema
  • Drug combination targeting intracellular osmotic pressure for the treatment of cerebral edema

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]A compound pharmaceutical composition with the effect of treating cerebral edema, comprising the following raw materials in parts by weight (Mol): 100 parts of sennoside A, 2 parts of cantharidin, 30 parts of nimodipine, cinepazide maleate 7.5 copies and 50 copies of Edaravone.

[0042] A preparation method of a compound pharmaceutical composition with the effect of treating cerebral edema, comprising the following steps:

[0043] (1) Take each raw material according to the concentration ratio in the aseptic operation room, and set aside;

[0044] (2) Grinding sennoside A, cantharidin, nimodipine, and cinepazide maleate into powders and mixing uniformly at a temperature of 25-35°C to obtain mixture A;

[0045] (3) Grinding Edaravone into powder and mixing uniformly at a temperature of 30-35°C to obtain mixture B;

[0046] (4) Mix the above-mentioned mixture A and mixture B evenly, put them at a temperature of 5-15° C. and let them stand for 20-30 minutes to obtain the ...

Embodiment 2

[0051] A compound pharmaceutical composition with the effect of treating cerebral edema, comprising the following raw materials in parts by weight (Mol): 50 parts of sennoside A, 2 parts of norcantharidin, 20 parts of nimodipine, cinnamon maleate Chite 10 parts and Edaravone 10 parts.

[0052] A preparation method of a compound pharmaceutical composition with the effect of treating cerebral edema, comprising the following steps:

[0053] (1) Take each raw material according to the concentration ratio in the aseptic operation room, and set aside;

[0054] (2) Grinding sennoside A, norcantharidin, nimodipine, and cinepazide maleate into powders and mixing them uniformly at a temperature of 25-35°C to obtain mixture A;

[0055] (3) Grinding Edaravone into powder and mixing uniformly at a temperature of 30-35°C to obtain mixture B;

[0056] (4) Mix the above-mentioned mixture A and mixture B evenly, put them at a temperature of 5-15° C. and let them stand for 20-30 minutes to ob...

Embodiment 3

[0060] A compound pharmaceutical composition with the effect of treating cerebral edema, comprising the following raw materials in parts by weight (Mol): 75 parts of sennoside A, 2 parts of cantharidin, 25 parts of nifedipine, cinepazide maleate 5 parts and edaravone 15 parts.

[0061] A preparation method of a compound pharmaceutical composition with the effect of treating cerebral edema, comprising the following steps:

[0062] (1) Take each raw material according to the concentration ratio in the aseptic operation room, and set aside;

[0063] (2) Grinding sennoside A, cantharidin, nifedipine, and cinepazide maleate into powders and mixing them uniformly at a temperature of 25-35°C to obtain mixture A;

[0064] (3) Grinding Edaravone into powder and mixing uniformly at a temperature of 30-35°C to obtain mixture B;

[0065] (4) Mix the above-mentioned mixture A and mixture B evenly, put them at a temperature of 5-15° C. and let them stand for 20-30 minutes to obtain the co...

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Abstract

A pharmaceutical composition for treating brain edema and a preparation method therefor. The active ingredients of the compound pharmaceutical composition include sennoside A, cantharidin or a derivative thereof, nimodipine or nifedipine, cinepazide maleate and edaravone. Cellular experiments are used to find active drugs and combinations thereof that can reduce colloidal osmotic pressure and crystal osmotic pressure in brain cells to treat brain edema and provide new pharmaceutical use in clinical applications.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating cerebral edema and a preparation method thereof. Background technique [0002] Cerebral edema is a high-risk pathological state stimulated by exogenous or endogenous pathogenic factors, manifested by abnormal increase of fluid in the brain parenchyma, increased brain volume, and increased intracranial pressure. The increase of intracranial pressure can lead to brain tissue ischemia and hypoxia, resulting in irreversible functional damage of nerve cells, and even brain herniation and even death. According to the mechanism of occurrence, cerebral edema is divided into 4 types: 1) vasogenic cerebral edema; 2) cytotoxic cerebral edema; 3) interstitial cerebral edema; 4) osmotic cerebral edema. If more than two mechanisms are combined at the same time, it is called mixed cerebral edema. The main mechanism of vasogenic cerebral edema is the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K31/34A61K31/4422A61K31/496A61K31/4152A61P25/00A61P7/10
CPCA61K31/34A61K31/4152A61K31/4422A61K31/496A61K31/704A61P7/10A61P25/00
Inventor 郭军吴辉文张家瑞王雨轩陈婷婷
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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