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Microfluidic chip and manufacturing technological method thereof

A technology of microfluidic chip and manufacturing process, which is applied in the direction of chemical instruments and methods, laboratory utensils, laboratory containers, etc., and can solve the needs of low cost, flexibility and scalability of devices and systems, Microfluidic systems are difficult to integrate microelectronic systems, electrical, electrochemical tests and other issues, so as to achieve the effects of convenient connection integration, easy manufacturing, and low material cost

Inactive Publication Date: 2018-10-16
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At the same time, due to the incompatibility of the production process, it is difficult to realize the integration of the traditional microfluidic system with the microelectronic system, so it is difficult to realize the electrical and electrochemical tests of the samples in the microfluidic. In terms of electrode and microfluidic system integration technology , corresponding to the above two microfluidic technologies
[0007] In short, no existing process or technology can meet the needs of corresponding devices and systems for low cost, flexibility and scalability in terms of rapid manufacturing and technical use

Method used

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  • Microfluidic chip and manufacturing technological method thereof
  • Microfluidic chip and manufacturing technological method thereof
  • Microfluidic chip and manufacturing technological method thereof

Examples

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Effect test

Embodiment 1

[0055] See attached Figure 1-4 , the microfluidic channel in this embodiment is only one layer, and the upper and lower sides can be directly exposed, or other braided materials (full hydrophobic, fully hydrophilic, or locally defined hydrophilic and hydrophobic according to specific requirements) can be used for upper and lower packaging according to specific implementation requirements; packaging The material can also be other common substrate materials (glass, silicon based, plastic, etc.). Such braided microfluidic devices can also be encapsulated with surface coatings. The packaging coating can be vacuum evaporation, magnetron sputtering, or solution methods such as spin coating and spray coating.

Embodiment 2

[0057] See attached Figure 5-9 , this embodiment is a multi-layer structure formed by superposition of two layers, and a three-dimensional microfluidic system can be realized by using different microfluidic channel networks defined between different layers.

[0058] Also according to specific implementation requirements, use other braided materials (fully hydrophobic, fully hydrophilic, or locally define hydrophilic and hydrophobic according to specific requirements) for upper and lower packaging; the packaging material can also be other common substrate materials (glass, silicon, plastic, etc.). Such braided microfluidic devices can also be encapsulated with surface coatings. The packaging coating can be vacuum evaporation, magnetron sputtering, or solution methods such as spin coating and spray coating.

[0059] Attachment to the above examples figure 2 Among them, the pattern of the 6-hydrophilic part is different to show the microfluidic channel for sampling in differe...

Embodiment 3

[0061] See attached Figure 13 , a cross-sectional view of a microfluidic chip, which is characterized in that it comprises at least three layers of braided or textile fabrics interwoven with warps and wefts, and the warps and wefts are composed of hydrophilic fibers. The above-mentioned braided or textile fabric interwoven with warp and weft is printed or coated with a hydrophobic microfluidic channel wall composed of a water-repellent coating, and between two adjacent hydrophobic microfluidic channel walls The hydrophilic fiber forms a microfluidic channel, and the adjacent interlayer microfluidic channels form a three-dimensional rotary microfluidic channel.

[0062] Based on the structure of this embodiment, the conductive electrodes can be directly laid between the layers by metal wires. Easy to process.

[0063] Using a mold or template layer (screen drain plate) 18, the water-blocking (ink, paint, etc.) layer 19 is printed on the water-permeable layer 20, the hydropho...

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Abstract

The invention discloses a microfluidic chip using fiber filaments for forming a microfluid channel, and an integrating and manufacturing technological method thereof, and belongs to the technical field of microfluidic chip manufacturing. The microfluidic chip is characterized by comprising at least one layer of braided fabric or woven fabric formed by interweaving a warp and a weft; each of the warp and the weft consists of hydrophilic fiber and a hydrophobic fiber; the hydrophilic fiber forms the microfluid channel and the hydrophobic fiber forms a microfluid channel wall; the hydrophilic fiber and the hydrophobic fiber of the warp and the weft can be integrally, partially or intermittently distributed. The microfluidic chip has the characteristics of low material cost, easiness in manufacturing and compatibility with the existing textile producing technological equipment; the microfluidic chip is convenient to use and can be directly cut and combined according to needs, so that connection and integration of a microfluid and a microelectronic system are conveniently achieved.

Description

technical field [0001] The invention discloses a microfluidic control chip using fiber filaments to form a microfluidic channel and its integration and manufacturing process, belonging to the technical field of microfluidic chip manufacturing. Background technique [0002] With the continuous expansion of the application range of microfluidic chips in the fields of rapid detection and on-site medical treatment, the market has a high demand for low cost and high integration of its technology. [0003] Existing microfluidic chips mainly include: [0004] 1. Traditional rigid microfluidic chips mainly use silicon base, polydimethylsiloxane (PDMS), polymethyl methacrylate (PMMA, or commonly known as acrylic) and other materials, and use photolithography, soft photolithography, inverted Mold, embossing, microcomputer processing and other means; the processing cycle is long, production requires professional equipment and environment, and the cost is relatively high. [0005] 2. ...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/502707
Inventor 马汉彬
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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