A kind of method of producing injection maltose crude drug

A technology of maltose and maltotriose enzyme, which is applied in the direction of pharmaceutical formulations, chemical instruments and methods, disaccharides, etc., can solve the problems of high price, high-purity crystalline maltose production started late, and achieve good granularity, easy separation of mother liquor, The effect of increasing the amount of seed

Active Publication Date: 2020-12-29
湖南金代科技发展有限公司
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The production of high-purity crystalline maltose in my country started relatively late. In China, only Henan Baofeng and Jiangsu Aogu produce a small part of crystalline maltose, with a content of only about 92%. It is only used in some oral preparations and foods, and it is used in the preparation of intravenous injections. The raw material medicine of maltose is only imported, and the price is expensive, more than 400,000 yuan per ton

Method used

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  • A kind of method of producing injection maltose crude drug
  • A kind of method of producing injection maltose crude drug

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Experimental program
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Effect test

Embodiment 1

[0037]Weigh 430g of cornstarch, make it into a volume of 2000mL with tap water, adjust the pH to 5.8 with hydrochloric acid, add 120 μL of high-temperature-resistant amylase, heat and liquefy in a water bath, keep it at 98°C for 15 minutes, adjust the pH to 4.0 with hydrochloric acid to inactivate the enzyme, and then Cool down to 60°C, add 5% NaOH to adjust the pH to 5.51, and obtain maltodextrin with a DE value of 5-6. Add 600 μL of pullulanase, 400 μL of Beta amylase, and 600 μL of maltotriose. After saccharifying at 60°C for 40 hours in a water bath, add 10 μL of medium-temperature amylase and 10 μL of glucoamylase, and keep saccharifying at 60°C for 12 hours. The maltose content is 94.2% detected by liquid phase, the temperature is raised to inactivate enzymes, activated carbon is added to decolorize, and filter paper is filtered to make the sugar solution clear and transparent, free of foreign matter and impurities visible to the naked eye. After passing through the anion...

Embodiment 2

[0039] It uses commercial maltodextrin (DE value 6-8) as raw material. Weigh 400g of commercial maltodextrin, make it into a volume of 2000mL, adjust the pH to 5.6, add 600μL of maltotriose, 600μL of pullulanase, and 400μL of Beta amylase, keep warm and saccharify in a water bath for 40 hours, then add medium temperature starch Enzyme 10μL, glucoamylase 10μL, keep warm and saccharify for 12 hours, sample liquid phase to detect maltose content 93.8%, heat up to inactivate enzyme, add activated carbon to decolorize, filter paper, pass through anion and cation exchange resin, conductivity 26μs / cm, concentrated to 72.5% , Stir and crystallize in a beaker, adopt the previous semi-crystallization process, cool down and crystallize in a water bath in a beaker, use a model IS-11 experimental centrifuge to separate, produce 181g of tidal sugar, mother liquor 45% concentration 405g, and dry in an oven 168g of finished crystalline maltose was obtained by sieving, and the quality inspecti...

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Abstract

The invention discloses a method for producing injection maltose bulk drug, and belongs to the field of food and medicine starch sugar production. Liquidation liquid with the DE value being 5 to 6 andqualified iodine reagent is prepared, so that the liquidation effect is improved; pullulanase, pullulanase, Beta amylase, middle temperature amylase and glucoamylase are added in batches at differentcatalytic time periods and simultaneously act; the saccharification effect is improved; the seed crystal quantity and the grain growing time are increased; the feeding is performed in batches, so that the crystallized sugar cake seed crystals are uniform; the granularity is high; the moth liquid separation is easy. By integrating the process conditions, the method completely reaches the standardsof Chinese pharmacopoeia in version 2015 on high-purity maltose; the important industrial production application potential is realized; the blank in China is hopeful filled.

Description

technical field [0001] The invention relates to a method for producing an injectable maltose raw material drug, which belongs to the field of food and medicine starch sugar production. Background technique [0002] Maltose is made from starch or starchy substance through liquefaction and saccharification. According to the product form, it is divided into liquid maltose, maltose powder and crystallized maltose. Maltose has good anti-corrosion and thermal stability, low hygroscopicity, and various physiological functions, and is widely used in the food and pharmaceutical industry. In the food industry, it is mainly used to make hard candy, beer syrup, and stuffing syrup. The main applications in the pharmaceutical industry are: (1) Oral maltose syrup to supplement the carbon source and energy needed by the body; (2) Properly proportioned with other nutrients as a nutritional supplement; (3) Used to manufacture maltitol, which is consumed by humans After adding maltitol, it ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P19/22C12P19/16C12P19/14C12P19/12C07H1/06C07H3/04A61K47/26A61K9/08
CPCA61K9/0019A61K9/0095A61K9/08A61K47/26C07H1/06C07H3/04C12P19/12C12P19/14C12P19/16C12P19/22
Inventor 崔楠谭启程张国军何球山
Owner 湖南金代科技发展有限公司
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