Self-assembly nano adjuvant and preparation method of nano vaccine formed by self-assembly nano adjuvant and application

A nano-vaccine and self-assembly technology, which is applied in the preparation of nano-vaccine and in the field of nano-vaccine, can solve problems such as application limitations, achieve good delivery effect, enhance vaccine targeting, and good immune effect
CN108714213AInactive Publication Date: 2018-10-30BEIJING UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING UNIV OF TECH
Publication Date
2018-10-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a self-assembly nano adjuvant and a preparation method of a nano vaccine formed by the self-assembly nano adjuvant and application. The nano adjuvant comprises self-assembly materials of protamine sulfates and carboxymethyl glucan, the self-assembly materials and CpG oligodeoxynucleotides self-assembly form the nano adjuvant, and the nano vaccine is formed by the nano adjuvant and the virus antigen. The nano adjuvant increases the bioavailability of the CpG oligodeoxynucleotides, degradation in the body is avoided, and the B type CpG is added the function of A type CpG. The nano vaccine not only can induce the humoral immune response of TH1 type, but also induce relatively high cellular immune response. The unvaccinated experiments in mice body proves that the nanovaccine has good protection function, which provides help in the application of nano vaccine in the future.
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Description

technical field

[0001] The invention belongs to the field of nanometer material biology. The invention relates to a nano-adjuvant formed by self-assembly and a nano-vaccine formed by the adjuvant, in particular to using protamine sulfate and carboxymethyl dextran as self-assembly materials together with CpG oligodeoxynucleotides A nano-adjuvant formed by self-assembly and a preparation method and application of a nano-vaccine formed by the nano-adjuvant and a virus antigen. Background technique

[0002] Viral vaccines include live attenuated vaccines, inactivated vaccines, and subunit vaccines. The inactivated virus is composed of a complete virus, which artificially loses or weakens its pathogenicity, but still maintains all or part of the immunogenicity of the virus. After vaccination, the virus antigen can stimulate the body to produce an immune response and achieve a protective effect. Due to its poor immune effect, inability to induce CTL response, short duration of t...

Claims

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