Nasal drop for treatment of acute and chronic rhinitis, sinusitis and allergic rhinitis and preparation method thereof

Abstract

The invention relates to a nasal drop for treatment of acute and chronic rhinitis, sinusitis and allergic rhinitis and a preparation method thereof. The nasal drop comprises neomycin sulfate, chlorpheniramine maleate, naphazoline hydrochloride, auxiliary ingredients and solvents. Specifically, per 1000ml of the nasal drops comprise 0.975-5 million units of neomycin sulfate, 0.3-1.0g of chloropheniramine maleate and 0.3-1.0g of naphthozoline hydrochloride. The nasal drop provided by the invention has anti-bacterial, anti-inflammation and anti-allergy effects, at the same time can constrict blood vessels and improve the nasal obstruction symptom caused by rhinitis, is atraumatic, and has the characteristics of easy carrying, convenient use, quick action, shortening of the course of disease,good patient compliance, and high cure rate, and has good efficacy on acute and chronic rhinitis, sinusitis and allergic rhinitis and the like. The preparation method of the nasal drop provided by theinvention has the advantages of simple and feasible processing technology and good repeatability, and is convenient for industrial production.

Description

technical field [0001] The invention relates to a rhinology pharmaceutical preparation, in particular to a nasal drop for treating acute and chronic rhinitis, sinusitis and allergic rhinitis and a preparation method thereof. Background technique [0002] Rhinitis and sinusitis are common and frequently-occurring clinical diseases, which can induce a variety of upper respiratory diseases. In recent years, air pollution has become increasingly serious, and harmful substances and allergic substances inhaled through the nose have increased, making the incidence of rhinitis and sinusitis significantly on the rise. . Children and adolescents have imperfect development of nasal mucosal barrier, low antibacterial ability and immune function, and poor tolerance to various harmful gases and allergens. They are high-risk groups of the disease. In particular, symptoms such as memory loss caused by chronic sinusitis seriously affect the patient's academic performance. [0003] At prese...

AI Technical Summary

Problems solved by technology

During the absorption and distribution of systemic drugs such as oral or injection, some drugs are destroyed by the gastrointestinal tract and liver or shunted by blood circulation, and the effective concentration that actually reaches the lesion in the nasal cavity and sinus cavity is very low, it is difficult to achieve the therapeutic effect, and it can induce bacteria Drug resistance makes the lesion become chronic, so the curative effect is poor and the cure rate is low; commonly used topical drugs, such as Dibijing, only have the ability to constrict blood vessels and improve nasal congestion caused by rhinitis. , and can cause drug-induced rhinitis

Laser therapy uses the high temperature generated by the laser beam to burn the lesions to eliminate inflammatory tissues and pathogenic bacteria. Since the laser beam cannot reach the sinus cavity, it can only be used for the treatment of rhinitis and nasal polyps. It is ineffective for sinusitis, and laser therapy is effective. Traumatic, cumbersome and expensive

Puncture therapy, using a puncture needle to pierce the bone plate of the outer wall of the nasal cavity and enter the sinus cavity, first extract the secretions and pus, and then inject the medicinal liquid into the sinus cavity to treat sinusitis, although it is effective, it is traumatic and the patient is more painful But can not adhere to, so can not consolidate the curative effect

The spray sprays the liquid medicine into the nasal cavity to produce local antibacterial and anti-inflammatory effects, which can be used to treat rhinitis. Because the liquid medicine cannot be sprayed directly into the nasal cavity, it is almost ineffective for sinusitis

[0004] The above drugs and methods, or the effective concentration of drugs that actually reach the lesion of the nasal cavity and sinus cavity is too low; or the pharmacological effect is single, and the toxic and side effects are large; or the drug cannot reach the sinus cavity, or the method is traumatic. Patients are more painful and cannot persist; or The operation method is cumbersome and the cost is high

Therefore, the medicines and methods currently used for clinical treatment of sinusitis and rhinitis have defects such as slow effect, poor curative effect, long course of treatment, low cure rate, large toxic and side effects, and high cost for patients.

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