Method for purifying folic acid

A purification method, folic acid technology, applied in the direction of organic chemistry, can solve problems such as inseparable, environmental pollution, difficult waste water, etc., and achieve the effects of low cost, reduced production, and simple operation

Inactive Publication Date: 2018-11-09
NANTONG CHANGHAI FOOD ADDITIVE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method generally needs to add a large amount of acid to dissolve the crude product of folic acid, then use a large amount of water to separate the folic acid, then dissolve the folic acid with alkali and then use acid to separate it, which will produce a large amount of difficult-to-handle waste water and cause serious environmental pollution.
[0008] Chinese patents CN104098569A, CN106749257A, and CN103102351A all introduce the purification and refining methods of folic acid respectively, but they are all inseparable from the traditional refining steps such as acid-soluble and alkali-soluble, and finally produce a large amount of waste water, which is not suitable for the industry in today's increasingly severe environmental protection situation. chemical production

Method used

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  • Method for purifying folic acid

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Experimental program
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Effect test

Embodiment 1

[0025] Pump 300kg of methanol into the 500-liter reactor, start stirring, put 43kg of crude folic acid with a purity of 60% from the manhole, start freezing and cool down to 10°C, after stirring evenly, slowly add 86kg of thionyl chloride dropwise from the head tank, At the same time, turn on the air induction and micro vacuum, and keep the temperature of the reactor at 10°C during the dropping process; after the dropping is completed, stir for another 2 hours until the solid is completely dissolved;

[0026] The clarified solution was filtered to remove the insoluble matter, and then the organic solvent was distilled under reduced pressure to remove 90% of the volume of methanol, the solvent was recovered and used mechanically, cooled to 0°C and stirred slowly for 2 hours, and the pure product of folic acid was obtained by pressure filtration after crystallization. The purity of folic acid was 97%. The yield was 96.6%.

Embodiment 2

[0028] Pump 220kg of ethanol into the 500-liter reactor, start stirring, put 43kg of crude folic acid with a purity of 63% from the manhole, start freezing and cool down to 10°C, after stirring evenly, slowly add 129kg of thionyl chloride dropwise from the head tank, At the same time, turn on the air induction and micro vacuum, and keep the temperature of the reactor at 10°C during the dropping process; after the dropping is completed, stir for another 2 hours until the solid is completely dissolved;

[0029] The clarified solution was filtered to remove insoluble matter, and then the organic solvent was distilled under reduced pressure to remove 80% of the volume of ethanol. The solvent was recovered and used mechanically. After cooling to 0°C, it was slowly stirred for 2 hours. After crystallization, it was press-filtered to obtain pure folic acid. The yield was 96.0%.

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Abstract

The invention provides a method for purifying folic acid. The method comprises the following steps: first, adding folic acid crude product into an organic solvent of a certain weight ratio, uniform stirring, lowering the temperature of the system to 0~20 DEG C; then slowly dropwise adding a certain amount of thionyl chloride to the folic acid turbid liquid, continuing to stir until the solid is completely dissolved, then stirring for 1~3 hours; finally, filtering the dissolved solution to remove insoluble matter, subjecting the organic solvent to vacuum distillation to remove most of the solvent, recycling the solvent, cooling to certain temperature, slowly stirring for 1~3 hours, performing crystallization, and performing filtration to obtain purified folic acid. The method for purifyingfolic acid provided by the invention is simple in operation and low in cost, and effectively reduces the generation of wastewater in folic acid purification, and is suitable for requirements of industrialization to environmental protection.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a method for purifying folic acid. Background technique [0002] Folic acid (folic acid), also called vitamin B9, is a water-soluble B vitamin, composed of pteridine, p-aminobenzoic acid and L-glutamic acid, also called pteroyl glutamic acid, slightly soluble in water, on It is unstable to heat, light, and acidic solutions, and stable to heat in neutral and alkaline solutions. It was named after it was discovered: vitamin M, vitamin Bc, R factor, etc. In 1941, because this biological factor was found from spinach, it was named folic acid. [0003] Folic acid is an essential substance when the human body utilizes sugar and amino acids, and is a necessary substance for the growth and reproduction of body cells. Folic acid is a coenzyme required for the synthesis of nucleic acids, helps regulate the development of embryonic nerve cells, prevents newborn babies from con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D475/04
CPCC07D475/04
Inventor 庄勇王立平赵海东顾京城
Owner NANTONG CHANGHAI FOOD ADDITIVE
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