Traditional Chinese medicine composition for treatment of gouty arthritis and/or hyperuricemia and preparations thereof

A technology for gouty arthritis and hyperuricemia, which is applied in the field of medicine, can solve the problems of Western medicine with large side effects, metastatic gout, and treat the symptoms but not the root cause, and achieve the effects of small human side effects, treatment of gout, and promotion of blood circulation

Inactive Publication Date: 2018-11-16
玉林市中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The western medicines currently used for gout have many side effects
In addition, taking uric acid-lowering western medicine during the intermittent period will rebound faster after stopping the drug, and it will also cause the attack of metastatic gout due to the rapid dissolution of uric acid

Method used

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  • Traditional Chinese medicine composition for treatment of gouty arthritis and/or hyperuricemia and preparations thereof
  • Traditional Chinese medicine composition for treatment of gouty arthritis and/or hyperuricemia and preparations thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1 Tablet

[0063] Weigh 10kg of Bixie, 15kg of Radix Polygoni, 15kg of Sea Jinsha, 7kg of piercing stone, 7kg of Chine Neijin, 5kg of Shiwei, 7kg of Motherwort, 15kg of Plantain, 5kg of Achyranthes, 7kg of Poria, and 5kg of Citrus aurantium;

[0064] Take all the medicinal materials, add water to extract twice after mixing, the amount of water added each time is equivalent to 12 times and 10 times the total weight of the medicinal materials, the two extraction times are 3 hours and 2 hours respectively, the extracts are combined, filtered, and the filtrate is concentrated at 70 ℃. A clear paste with a relative density of 1.10 was added to the tablet excipients, powdered sugar, ethanol, gelatin, crospovidone, and talc, and tablets were prepared according to the conventional scheme.

Embodiment 2

[0065] Example 2 Tablet

[0066] Weigh 12kg of Bixie, 18kg of Radix Polygoni, 18kg of Sea Jinsha, 9kg of piercing stone, 9kg of Chine Neijin, 6kg of Shiwei, 8kg of Motherwort, 19kg of Plantain, 7kg of Achyranthes, 9kg of Poria, and 6kg of Citrus aurantium;

[0067] All the medicinal materials were taken, mixed and extracted with 40% ethanol for 3 times. The amount of ethanol each time was 10 times, 8 times, and 6 times the total weight of the medicinal materials. The three extraction times were 4 hours, 2 hours, and 1 hour, respectively. Combine the extracts , filtered, the filtrate was concentrated to a clear paste with a relative density of 1.05 when the filtrate was concentrated at 70°C, and the tablet auxiliary materials such as lactose, polyethylene glycol, starch, and magnesium stearate were added, and the tablet was prepared according to the conventional scheme.

Embodiment 3

[0068] Example 3 Capsules

[0069] Weigh 15kg of Bixie, 22kg of Radix Polygoni, 23kg of Sea Jinsha, 11kg of piercing stone, 10kg of Chine Neijin, 8kg of Shiwei, 10kg of Motherwort, 21kg of Plantain, 10kg of Achyranthes, 12kg of Poria, and 7kg of Citrus aurantium;

[0070] Take all the medicinal materials, add water after mixing and extract twice, the amount of water added each time is equivalent to 12 times and 8 times the total weight of the medicinal materials, and the extraction time is 3 hours and 2 hours respectively. Combine the extracts, filter, and concentrate the filtrate to 70 ° C When the relative density is 1.10, add ethanol to make the alcohol content 40%, let stand for 12 hours, filter, and concentrate the filtrate to the extract with the relative density of 1.05 when the filtrate is concentrated at 70°C, add capsule auxiliary dextrin, cellulose Derivatives, ethanol, sodium carboxymethyl starch, talc, and capsules were prepared according to the conventional schem...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treatment of gouty arthritis and / or hyperuricemia, wherein the traditional Chinese medicine composition is prepared from rhizomadioscoreae colletii, herba desmodii styracifolii, lygodium japonicum, radix cudramiae, endothelium corneum gigeriae galli, folium pyrrosiae, leonurus, plantain herb, radix achyranthis bidentatae, poria cocos and fructus aurantii immaturus. The traditional Chinese medicine composition is prepared from a variety of traditional Chinese medicinal materials and has the functions of removing dampness for causing diuresis, promoting blood circulation and removing swelling, removing blood stasis and dredging collaterals, tonifying kidney and liver, strengthening muscles and bones and the like, and caneffectively treat gouty arthritis and / or hyperuricemia. The traditional Chinese medicine composition can also be made into capsules, granules, oral liquids and other preparations, can be convenient to take and carry, meets the taking and carrying of patients in different illness conditions, and is applicable to a wide range of people. In addition, the traditional Chinese medicine composition hasscientific and reasonable formula, small side effects, simple preparation method and low preparation cost, can greatly alleviate the body and economic burden of patients, and has great promotion value.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition and preparation thereof for treating gouty arthritis and / or hyperuricemia. Background technique [0002] Gout is due to purine metabolism disorder, excessive uric acid production or poor uric acid excretion resulting in increased blood urea, urate crystal deposition in joint synovium, bursa, cartilage and other tissues caused by repeated attacks of joint redness, swelling, heat and pain. of chronic, systemic diseases. Clinical features are hyperuricemia, recurrent episodes of acute gouty arthritis, tophi formation, chronic arthritis and joint deformities, as well as uric acid stones and gouty renal parenchyma later in the course of the disease. [0003] Hyperuricemia is a purine metabolic disease, a state of the body in which the concentration of uric acid in the blood exceeds the normal range (it is generally considered that serum uric acid >...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P19/02A61P19/06A61P29/00A61K35/57
CPCA61K35/57A61K36/076A61K36/12A61K36/21A61K36/48A61K36/533A61K36/60A61K36/68A61K36/752A61K36/8945A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P19/02A61P19/06A61P29/00A61K2300/00
Inventor 谢学光陈甲秀臧海珍许小香李代伟陈健伍彦洁王熙凤
Owner 玉林市中医医院
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