A kind of anticancer red ginseng and its preparation method and application

A technology of red ginseng and ginseng, applied in the field of anti-cancer red ginseng and its preparation, to achieve the effect of clear components, remarkable anti-cancer effect and exact content

Active Publication Date: 2020-08-21
SUNFLOWER PHARM GRP (TIANJIN) DRUG RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the preparation of red ginseng containing aglycone by utilizing the synergistic enzyme system of ginseng itself

Method used

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  • A kind of anticancer red ginseng and its preparation method and application
  • A kind of anticancer red ginseng and its preparation method and application
  • A kind of anticancer red ginseng and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1: The preparation method of highly active anticancer red ginseng

[0070] Select 1 kg of fresh ginseng without disease, soak it in water for 30 minutes, wash it, place it in an incubator and keep the temperature at 110°C for 20 minutes to activate the ginseng glycosidase, then cool it down to 50°C naturally, and keep it warm for 10 minutes. The traditional Chinese medicine glucosidase I fully reacts with the original ginsenoside; then quickly raise the temperature to 65°C and keep it warm for 15 minutes to make the Chinese medicine glucosidase II fully react with the ginsenoside; then raise the temperature to 80°C and keep it warm for 18 minutes Fully react with ginsenosides; then rapidly raise the temperature to 145°C and treat for 45 minutes to inactivate the enzyme of traditional Chinese medicine sidase. Finally, it is dried at 60°C until the water content is less than 10% to obtain the finished high-activity anti-cancer red ginseng. Finished products su...

Embodiment 2

[0082] Embodiment 2: the preparation method of anticancer American red ginseng

[0083]Select 1 kg of fresh American ginseng without lesions, soak it in water for 10 minutes, wash it, place it in an incubator and keep the temperature at 105°C for 28 minutes to activate ginseng glycosidase, then cool it down to 55°C naturally, and keep it warm for 9 minutes. The traditional Chinese medicine glucosidase I fully reacts with the original ginsenoside; then quickly raise the temperature to 60°C and keep it warm for 17 minutes to make the Chinese medicine glucosidase II fully react with the ginsenoside; then raise the temperature to 73°C and keep it warm for 17 minutes Fully react with ginsenoside; then rapidly raise the temperature to 150°C and treat for 30 minutes to inactivate the enzyme of traditional Chinese medicine sidase. Finally, it is dried at 60°C until the water content is less than 10% to obtain the finished high-activity anti-cancer American red ginseng.

Embodiment 3

[0090] Embodiment 3: the preparation method of anticancer notoginseng red ginseng

[0091] Select 1 kg of fresh Panax notoginseng without lesions, soak it in water for 18 minutes, wash it, place it in an incubator and keep the temperature at 115°C for 15 minutes to activate the ginseng traditional Chinese medicine glucosidase; then cool it naturally to 50°C and keep it warm for 14 minutes , so that the traditional Chinese medicine glucosidase I fully reacts with the original ginsenoside; then quickly raise the temperature to 65 ° C, and keep it warm for 15 minutes, so that the traditional Chinese medicine glucoside enzyme II and ginsenoside fully react; then raise the temperature to 85 ° C, and keep it for 16 minutes Enzyme III fully reacts with ginsenoside; then rapidly raise the temperature to 121°C and treat for 60 minutes to inactivate the enzyme of traditional Chinese medicine glycosidase. Finally, it is dried at 60°C until the water content is less than 10% to obtain the...

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Abstract

The invention provides anticancer red ginseng and a preparation method and the application thereof. In the anticancer red ginseng, the molar number of rare ginsenosides and sapogenin accounts for morethan 70% of the molar number of total saponin, wherein the molar number of the sapogenin accounts for more than 20% of the molar number of the total saponin; and under the condition of not introducing any foreign substances, three natural traditional Chinese medicine glycosides enzymes in ginseng are activated, and under the action of three synergistic enzymes, different catalytic reactions are controlled to be activated under different conditions, so that original ginseng saponins which are low in activity and hard to absorb, such as Rb, Rc, Rd, Re, Rf, and Rg1, are converted into the rare saponin and sapogenin which are high inactivity. The anticancer red ginseng has the remarkable anticancer effect and the broad prospect in the preparation of anticancer drugs.

Description

technical field [0001] The invention belongs to the field of red ginseng processing, and in particular relates to an anticancer red ginseng and its preparation method and application. Background technique [0002] Panax ginseng plays an irreplaceable role in the field of traditional Chinese medicine in my country because of its outstanding medicinal value. Ginseng is both the name of the species and the name of the genus. The genus Panax belongs to the family Araliaceae, including more than ten species. Seven ginseng) bamboo ginseng, etc. Saponin components, that is, ginsenoside is its iconic active ingredient. Saponins are formed by connecting non-sugar-based ligands and sugar groups through glycosidic bonds. The highest content is tetracyclic triterpene dammarane-type protodiol saponins , Protopanaxatriol saponins. The structures of these two types of natural saponins are as follows: [0003] [0004] [0005] Ginsenoside is the main functional component in ginse...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61K31/704A61P35/00A61K8/63A61Q19/00
CPCA61K8/63A61K31/575A61K31/704A61P35/00A61Q19/00A61K2300/00
Inventor 肖永坤王东明栾桂花
Owner SUNFLOWER PHARM GRP (TIANJIN) DRUG RES INST CO LTD
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